Prediction of similar transforming regions in simian virus 40 large T, adenovirus E1A, and myc oncoproteins

Regions containing similar elements of primary and predicted secondary structure were identified in simian virus 40 large T, adenovirus E1A, c-myc and v-myc proteins by a computer program with a set of highly specific, complex pattern descriptors. In all cases these regions were localized in domains of the respective proteins known to be required for transforming activity. We suggest that these apparently structurally similar regions may mediate a common biological function.

[1]  R H Lathrop,et al.  Prediction of a common structural domain in aminoacyl-tRNA synthetases through use of a new pattern-directed inference system. , 1987, Biochemistry.

[2]  D. Kalderon,et al.  In vitro mutagenesis of a putative DNA binding domain of SV40 large-T. , 1984, Virology.

[3]  T. Hunter.  A thousand and one protein kinases , 1987, Cell.

[4]  P. Leder,et al.  Evolutionarily conserved regions of the human c-myc protein can be uncoupled from transforming activity. , 1987, Proceedings of the National Academy of Sciences of the United States of America.

[5]  J. Lillie,et al.  An adenovirus E1a protein region required for transformation and transcriptional repression , 1986, Cell.

[6]  R. Weinberg,et al.  The action of oncogenes in the cytoplasm and nucleus. , 1985, Science.

[7]  J. Bishop,et al.  The protein products of the myc and myb oncogenes and adenovirus E1a are structurally related , 1983, Nature.

[8]  B. Opalka,et al.  Definition of a region required for transformation in E1a of adenovirus 12. , 1987, Virology.

[9]  M. Mathews,et al.  Different functional domains of the adenovirus E1A gene are involved in regulation of host cell cycle products , 1987 .

[10]  P. Argos,et al.  The release of growth arrest by microinjection of adenovirus E1A DNA. , 1985, The EMBO journal.

[11]  J. Nevins,et al.  Selective induction of human heat shock gene transcription by the adenovirus E1A gene products, including the 12S E1A product , 1987, Molecular and cellular biology.

[12]  G. Hathaway,et al.  Casein kinases--multipotential protein kinases. , 1982, Current topics in cellular regulation.

[13]  N. Jones,et al.  Mutational analysis of the adenovirus E1a gene: the role of transcriptional regulation in transformation. , 1987, The EMBO journal.

[14]  G. Chinnadurai,et al.  Relationship between the transforming and transcriptional regulatory functions of adenovirus 2 E1a oncogene. , 1987, Virology.

[15]  R. Gaynor,et al.  Genetic mapping of a major site of phosphorylation in adenovirus type 2 E1A proteins , 1986, Journal of virology.

[16]  P. Y. Chou,et al.  Conservation of chain reversal regions in proteins. , 1979, Biophysical journal.

[17]  M. Mathews,et al.  Identification of separate domains in the adenovirus E1A gene for immortalization activity and the activation of virus early genes , 1986, Molecular and cellular biology.

[18]  R. Tjian,et al.  Positive and negative regulation of transcription in vitro: Enhancer-binding protein AP-2 is inhibited by SV40 T antigen , 1987, Cell.

[19]  R. Roberts,et al.  Different functional domains of the adenovirus E1A gene are involved in regulation of host cell cycle products , 1987, Molecular and cellular biology.

[20]  Richard H. Lathrop,et al.  ARIADNE: pattern-directed inference and hierarchical abstraction in protein structure recognition , 1987, CACM.

[21]  P. Y. Chou,et al.  Empirical predictions of protein conformation. , 1978, Annual review of biochemistry.

[22]  P. Leder,et al.  A translocated human c-myc oncogene is altered in a conserved coding sequence. , 1986, Proceedings of the National Academy of Sciences of the United States of America.

[23]  P. Y. Chou,et al.  Prediction of the secondary structure of proteins from their amino acid sequence. , 2006 .

[24]  D. E. Groff,et al.  Molecular cloning and nucleotide sequence of deer papillomavirus , 1985, Journal of virology.

[25]  Kathryn E. Sidman,et al.  The protein identification resource (PIR). , 1986, Nucleic acids research.

[26]  H. Ruley,et al.  Two regions of the adenovirus early region 1A proteins are required for transformation , 1988, Journal of virology.

[27]  D. Kalderon,et al.  Simian virus 40 origin DNA-binding domain on large T antigen , 1986, Journal of virology.

[28]  H. M. Temin.  Viral oncogenes. , 1980, Cold Spring Harbor symposia on quantitative biology.

[29]  J. Hoppe,et al.  Substrate specificity of the nuclear protein kinase NII from porcine liver. Studies with casein variants. , 2005, European journal of biochemistry.

[30]  K. Scheidtmann,et al.  Simian Virus 40 Large T Antigen Is Phosphorylated at Multiple Sites Clustered in Two Separate Regions , 1982, Journal of virology.

[31]  P. Y. Chou,et al.  Occurrence of phosphorylated residues in predicted β-turns: Implications for β-turn participation in control mechanisms , 1977 .

[32]  H. Ruley.  Adenovirus early region 1A enables viral and cellular transforming genes to transform primary cells in culture , 1983, Nature.

[33]  James W. Fickett,et al.  The GenBank genetic sequence databank , 1986, Nucleic Acids Res..

[34]  H. Varmus,et al.  Definition of regions in human c-myc that are involved in transformation and nuclear localization , 1987, Molecular and cellular biology.

[35]  P. Sharp,et al.  Transcription Control by Oncogenes , 1985, Cell.

[36]  Teresa A. Webster,et al.  A modified Chou and Fasman protein structure algorithm , 1987, Comput. Appl. Biosci..

[37]  R H Lathrop,et al.  Consensus topography in the ATP binding site of the simian virus 40 and polyomavirus large tumor antigens. , 1987, Proceedings of the National Academy of Sciences of the United States of America.

[38]  Robert A. Weinberg,et al.  Tumorigenic conversion of primary embryo fibroblasts requires at least two cooperating oncogenes , 1983, Nature.

[39]  J. Lillie,et al.  Functional domains of adenovirus type 5 E1a proteins , 1987, Cell.