Hybridization chain reactions on silica coated Qbeads for the colorimetric detection of multiplex microRNAs.

A robust Qbead platform that integrated with target-binding, hybridization chain reaction and staining was developed for the direct multiplexed detection of endogenous miRNAs by amplified Qbead-colour change.

[1]  S. Luo,et al.  Highly sensitive and specific microRNA expression profiling using BeadArray technology , 2008, Nucleic acids research.

[2]  Zhan Wu,et al.  Electrostatic nucleic acid nanoassembly enables hybridization chain reaction in living cells for ultrasensitive mRNA imaging. , 2015, Journal of the American Chemical Society.

[3]  F. Slack,et al.  Oncomirs — microRNAs with a role in cancer , 2006, Nature Reviews Cancer.

[4]  R. Corn,et al.  Multiplexed detection methods for profiling microRNA expression in biological samples. , 2008, Angewandte Chemie.

[5]  H. Horvitz,et al.  MicroRNA expression profiles classify human cancers , 2005, Nature.

[6]  D. Walt,et al.  Microsphere-based rolling circle amplification microarray for the detection of DNA and proteins in a single assay. , 2009, Analytical chemistry.

[7]  Robert M. Dirks,et al.  An autonomous polymerization motor powered by DNA hybridization , 2007, Nature Nanotechnology.

[8]  Huangxian Ju,et al.  MicroRNA: function, detection, and bioanalysis. , 2013, Chemical reviews.

[9]  Wei Ren,et al.  A cytometric bead assay for sensitive DNA detection based on enzyme-free signal amplification of hybridization chain reaction. , 2013, Biosensors & bioelectronics.

[10]  Shuming Nie,et al.  Quantum dot-encoded mesoporous beads with high brightness and uniformity: rapid readout using flow cytometry. , 2004, Analytical chemistry.

[11]  Zhijuan Cao,et al.  Hybridization chain reaction modulated DNA-hosted silver nanoclusters for fluorescent identification of single nucleotide polymorphisms in the let-7 miRNA family. , 2014, Biosensors & bioelectronics.

[12]  Niko Hildebrandt,et al.  Rapid and Multiplexed MicroRNA Diagnostic Assay Using Quantum Dot-Based Förster Resonance Energy Transfer. , 2015, ACS nano.

[13]  H. Schroeder,et al.  Quantum-dot-encoded silica nanospheres for nucleic acid hybridization. , 2010, Small.

[14]  Robert M. Dirks,et al.  Triggered amplification by hybridization chain reaction. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[15]  Wei Ren,et al.  Graphene surface-anchored fluorescence sensor for sensitive detection of microRNA coupled with enzyme-free signal amplification of hybridization chain reaction. , 2012, ACS applied materials & interfaces.

[16]  Paolo A Netti,et al.  Supramolecular spectrally encoded microgels with double strand probes for absolute and direct miRNA fluorescence detection at high sensitivity. , 2015, Journal of the American Chemical Society.

[17]  Xiaobo Zhang,et al.  Lab on a single microbead: an ultrasensitive detection strategy enabling microRNA analysis at the single-molecule level† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c5sc02641e , 2015, Chemical science.

[18]  Chad A Mirkin,et al.  Scanometric microRNA array profiling of prostate cancer markers using spherical nucleic acid-gold nanoparticle conjugates. , 2012, Analytical chemistry.

[19]  T. Litman,et al.  MicroRNA expression profiling using LNA-modified probes in a liquid-phase bead-based array , 2007 .

[20]  Zhike He,et al.  An ultrasensitive biosensor for DNA detection based on hybridization chain reaction coupled with the efficient quenching of a ruthenium complex to CdTe quantum dots. , 2013, Chemical communications.

[21]  Ryan C Bailey,et al.  Emerging Biosensing Approaches for microRNA Analysis. , 2016, Analytical chemistry.

[22]  S. Nie,et al.  Quantum-dot-tagged microbeads for multiplexed optical coding of biomolecules , 2001, Nature Biotechnology.

[23]  D. Bartel.  MicroRNAs Genomics, Biogenesis, Mechanism, and Function , 2004, Cell.

[24]  A. Lal,et al.  MicroRNAs and their target gene networks in breast cancer , 2010, Breast Cancer Research.

[25]  Yun Chen,et al.  Quantification of microRNA by DNA-Peptide Probe and Liquid Chromatography-Tandem Mass Spectrometry-Based Quasi-Targeted Proteomics. , 2016, Analytical chemistry.

[26]  Xiaohu Gao,et al.  Stable Encapsulation of Quantum Dot Barcodes with Silica Shells , 2010 .

[27]  Chun-yang Zhang,et al.  Sensitive detection of microRNA with isothermal amplification and a single-quantum-dot-based nanosensor. , 2012, Analytical chemistry.

[28]  S. Tavazoie,et al.  Control of metastatic progression by microRNA regulatory networks , 2013, Nature Cell Biology.

[29]  C. Lau,et al.  xMAP array microspheres based stem-loop structured probes as conformational switches for multiplexing detection of miRNAs. , 2014, Analytical chemistry.

[30]  Lin He,et al.  MicroRNAs: small RNAs with a big role in gene regulation , 2004, Nature reviews genetics.

[31]  G. Dreyfuss,et al.  Numerous microRNPs in neuronal cells containing novel microRNAs. , 2003, RNA.