In Vivo Imaging of Matrix Metalloproteinase 12 and Matrix Metalloproteinase 13 Activities in the Mouse Model of Collagen‐Induced Arthritis

To develop enzyme‐activatable Förster resonance energy transfer (FRET) substrate probes to detect matrix metalloproteinase 12 (MMP‐12) and MMP‐13 activities in vivo in mouse models of inflammatory arthritis.

[1]  Meng Yang,et al.  Activatable near-infrared fluorescent probe for in vivo imaging of fibroblast activation protein-alpha. , 2012, Bioconjugate chemistry.

[2]  M. Inouye,et al.  Defining Requirements for Collagenase Cleavage in Collagen Type III Using a Bacterial Collagen System* , 2012, The Journal of Biological Chemistry.

[3]  M. Bogyo,et al.  Functional imaging of proteases: recent advances in the design and application of substrate-based and activity-based probes. , 2011, Current opinion in chemical biology.

[4]  Kwangmeyung Kim,et al.  Early diagnosis of arthritis in mice with collagen-induced arthritis, using a fluorogenic matrix metalloproteinase 3-specific polymeric probe. , 2011, Arthritis and rheumatism.

[5]  B. Turk,et al.  Functional in vivo imaging of cysteine cathepsin activity in murine model of inflammation. , 2011, Bioorganic & medicinal chemistry.

[6]  Ingebrigt Sylte,et al.  Regulation of matrix metalloproteinase activity in health and disease , 2011, The FEBS journal.

[7]  Ngee Han Lim,et al.  In vivo optical imaging in arthritis--an enlightening future? , 2010, Rheumatology.

[8]  Z. Werb,et al.  Matrix metalloproteinase 13-deficient mice are resistant to osteoarthritic cartilage erosion but not chondrocyte hypertrophy or osteophyte development. , 2009, Arthritis and rheumatism.

[9]  E. Novellino,et al.  N-O-isopropyl sulfonamido-based hydroxamates: design, synthesis and biological evaluation of selective matrix metalloproteinase-13 inhibitors as potential therapeutic agents for osteoarthritis. , 2009, Journal of medicinal chemistry.

[10]  M. Bogyo,et al.  Noninvasive optical imaging of apoptosis by caspase-targeted activity-based probes , 2009, Nature Medicine.

[11]  R. Gay,et al.  Extended Report , 2022 .

[12]  M. Meldal,et al.  Multiple column peptide synthesis, Part 2 (1, 2). , 2009, International journal of peptide and protein research.

[13]  C. Overall,et al.  Macrophage-specific metalloelastase (MMP-12) truncates and inactivates ELR+ CXC chemokines and generates CCL2, -7, -8, and -13 antagonists: potential role of the macrophage in terminating polymorphonuclear leukocyte influx. , 2008, Blood.

[14]  Ick Chan Kwon,et al.  Dark quenched matrix metalloproteinase fluorogenic probe for imaging osteoarthritis development in vivo. , 2008, Bioconjugate chemistry.

[15]  Gillian Murphy,et al.  Reappraising metalloproteinases in rheumatoid arthritis and osteoarthritis: destruction or repair? , 2008, Nature Clinical Practice Rheumatology.

[16]  B. Fingleton MMPs as therapeutic targets--still a viable option? , 2008, Seminars in cell & developmental biology.

[17]  B. Zheng,et al.  Gene expression profiles at different stages of collagen-induced arthritis , 2008, Autoimmunity.

[18]  Georges von Degenfeld,et al.  Noninvasive optical imaging of cysteine protease activity using fluorescently quenched activity-based probes. , 2007, Nature chemical biology.

[19]  Ralph Weissleder,et al.  Optical Visualization of Cathepsin K Activity in Atherosclerosis With a Novel, Protease-Activatable Fluorescence Sensor , 2007, Circulation.

[20]  Philippe Cuniasse,et al.  Development of Selective Inhibitors and Substrate of Matrix Metalloproteinase-12* , 2006, Journal of Biological Chemistry.

[21]  M. Abrahamowicz,et al.  Radiographic joint damage in rheumatoid arthritis is associated with differences in cartilage turnover and can be predicted by serum biomarkers: an evaluation from 1 to 4 years after diagnosis , 2006, Arthritis research & therapy.

[22]  Kinneret Keren,et al.  Dynamic imaging of protease activity with fluorescently quenched activity-based probes , 2005, Nature chemical biology.

[23]  Jiqiu Chen,et al.  Near-Infrared Fluorescent Imaging of Matrix Metalloproteinase Activity After Myocardial Infarction , 2005, Circulation.

[24]  Roger Y Tsien,et al.  Tumor imaging by means of proteolytic activation of cell-penetrating peptides. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[25]  Jianglin Fan,et al.  Overexpression of human matrix metalloproteinase-12 enhances the development of inflammatory arthritis in transgenic rabbits. , 2004, The American journal of pathology.

[26]  Hajime Mishima,et al.  Association of increased expression of macrophage elastase (matrix metalloproteinase 12) with rheumatoid arthritis. , 2004, Arthritis and rheumatism.

[27]  K. Brew,et al.  E. coli expression of TIMP-4 and comparative kinetic studies with TIMP-1 and TIMP-2: insights into the interactions of TIMPs and matrix metalloproteinase 2 (gelatinase A). , 2002, Biochemistry.

[28]  J. Delaissé,et al.  Solid phase combinatorial library of phosphinic peptides for discovery of matrix metalloproteinase inhibitors. , 2000, Journal of combinatorial chemistry.

[29]  R. Weissleder,et al.  In vivo imaging of tumors with protease-activated near-infrared fluorescent probes , 1999, Nature Biotechnology.

[30]  T Kobayashi,et al.  Expression and localization of matrix metalloproteinase-12 in the aorta of cholesterol-fed rabbits: relationship to lesion development. , 1998, The American journal of pathology.

[31]  B. Bresnihan,et al.  Synovial tissue macrophages and joint erosion in rheumatoid arthritis. , 1994, Annals of the rheumatic diseases.

[32]  T. Ley,et al.  Cloning and characterization of a unique elastolytic metalloproteinase produced by human alveolar macrophages. , 1993, The Journal of biological chemistry.

[33]  B. Dijkmans,et al.  Macrophage positron emission tomography imaging as a biomarker for preclinical rheumatoid arthritis: findings of a prospective pilot study. , 2012, Arthritis and rheumatism.

[34]  Linda Troeberg,et al.  Proteases involved in cartilage matrix degradation in osteoarthritis. , 2012, Biochimica et biophysica acta.

[35]  C. López-Otín,et al.  Matrix metalloproteinases: evolution, gene regulation and functional analysis in mouse models. , 2010, Biochimica et biophysica acta.

[36]  Richard O. Williams,et al.  Protocol for the induction of arthritis in C57BL/6 mice , 2008, Nature Protocols.

[37]  V. Turk,et al.  Selective activity-based probes for cysteine cathepsins. , 2008, Angewandte Chemie.

[38]  B. Fiedler,et al.  Interference of antihypertrophic molecules and signaling pathways with the Ca2+-calcineurin-NFAT cascade in cardiac myocytes. , 2004, Cardiovascular research.

[39]  A. Poole,et al.  Postnatal expression in hyaline cartilage of constitutively active human collagenase-3 (MMP-13) induces osteoarthritis in mice. , 2001, The Journal of clinical investigation.

[40]  R. Visse,et al.  This Review Is Part of a Thematic Series on Matrix Metalloproteinases, Which Includes the following Articles: Matrix Metalloproteinase Inhibition after Myocardial Infarction: a New Approach to Prevent Heart Failure? Matrix Metalloproteinases in Vascular Remodeling and Atherogenesis: the Good, the Ba , 2022 .