Impact of amino acid substitutions in hepatitis C virus genotype 1b core region on liver steatosis and glucose tolerance in non‐cirrhotic patients without overt diabetes

Background and Aim:  The hepatitis C virus (HCV) core protein induces hepatic steatosis and glucose intolerance in transgenic mice. The aim of this study was to clarify the impact of mutations in the HCV core region on hepatic steatosis and glucose tolerance in patients with chronic hepatitis C.

[1]  F. Negro Hepatitis C Virus-Induced Steatosis: An Overview , 2010, Digestive Diseases.

[2]  K. Hayashi,et al.  Impact of amino acid substitutions in the hepatitis C virus genotype 1b core region on liver steatosis and hepatic oxidative stress in patients with chronic hepatitis C , 2010, Liver international : official journal of the International Association for the Study of the Liver.

[3]  P. Berry,et al.  The importance of steatosis in chronic hepatitis C infection and its management: A review , 2010, Hepatology research : the official journal of the Japan Society of Hepatology.

[4]  Y. Maehara,et al.  Impact of amino acid substitutions in the core region of HCV on multistep hepatocarcinogenesis , 2010, Hepatology research : the official journal of the Japan Society of Hepatology.

[5]  K. Chayama,et al.  Predictive values of amino acid sequences of the core and NS5A regions in antiviral therapy for hepatitis C: a Japanese multi-center study , 2009, Journal of Gastroenterology.

[6]  Yoshiyuki Suzuki,et al.  Amino acid substitutions in the hepatitis C virus core region of genotype 1b are the important predictor of severe insulin resistance in patients without cirrhosis and diabetes mellitus , 2009, Journal of medical virology.

[7]  R. Jhaveri,et al.  Specific polymorphisms in hepatitis C virus genotype 3 core protein associated with intracellular lipid accumulation. , 2008, The Journal of infectious diseases.

[8]  J. Girard,et al.  Role of ChREBP in hepatic steatosis and insulin resistance , 2008, FEBS letters.

[9]  M. Matsuda,et al.  Muscle and Liver Insulin Resistance Indexes Derived From the Oral Glucose Tolerance Test , 2007, Diabetes Care.

[10]  L. Babiuk,et al.  Up-regulation of fatty acid synthase promoter by hepatitis C virus core protein: genotype-3a core has a stronger effect than genotype-1b core. , 2007, Journal of hepatology.

[11]  Milton W. Taylor,et al.  Pretreatment Sequence Diversity Differences in the Full-Length Hepatitis C Virus Open Reading Frame Correlate with Early Response to Therapy , 2007, Journal of Virology.

[12]  Kyoko Sakai,et al.  Correlation of hepatic steatosis with body mass index, serum ferritin level and hepatic fibrosis in Japanese patients with chronic hepatitis C , 2007, Hepatology research : the official journal of the Japan Society of Hepatology.

[13]  Yoshiyuki Suzuki,et al.  Predictive factors of early and sustained responses to peginterferon plus ribavirin combination therapy in Japanese patients infected with hepatitis C virus genotype 1b: amino acid substitutions in the core region and low-density lipoprotein cholesterol levels. , 2007, Journal of hepatology.

[14]  Keiji Tanaka,et al.  Critical role of PA28γ in hepatitis C virus-associated steatogenesis and hepatocarcinogenesis , 2007, Proceedings of the National Academy of Sciences.

[15]  M. Soresi,et al.  Impact of liver steatosis on the antiviral response in the hepatitis C virus‐associated chronic hepatitis , 2006, Liver international : official journal of the International Association for the Study of the Liver.

[16]  T. Asselah,et al.  STEATOSIS IN CHRONIC HEPATITIS C: WHY DOES IT REALLY MATTER? , 2005, Gut.

[17]  K. Koike Hepatitis C Virus Infection Can Present with Metabolic Disease by Inducing Insulin Resistance , 2005, Intervirology.

[18]  Yoshiyuki Suzuki,et al.  Association of Amino Acid Substitution Pattern in Core Protein of Hepatitis C Virus Genotype 1b High Viral Load and Non-Virological Response to Interferon-Ribavirin Combination Therapy , 2005, Intervirology.

[19]  C. Sabin,et al.  Insulin Resistance Plays a Significant Role in Liver Fibrosis in Chronic Hepatitis C and in the Response to Antiviral Therapy , 2005, The American Journal of Gastroenterology.

[20]  A. Clouston,et al.  Steatosis: Co‐factor in other liver diseases , 2005, Hepatology.

[21]  D. Wendum,et al.  Insulin resistance is a cause of steatosis and fibrosis progression in chronic hepatitis C , 2005, Gut.

[22]  O. Cummings,et al.  Design and validation of a histological scoring system for nonalcoholic fatty liver disease , 2005, Hepatology.

[23]  R. Andrade,et al.  Insulin resistance impairs sustained response rate to peginterferon plus ribavirin in chronic hepatitis C patients. , 2005, Gastroenterology.

[24]  T. Kawaguchi,et al.  Hepatitis C virus down-regulates insulin receptor substrates 1 and 2 through up-regulation of suppressor of cytokine signaling 3. , 2004, The American journal of pathology.

[25]  J. McHutchison,et al.  The impact of steatosis on disease progression and early and sustained treatment response in chronic hepatitis C patients. , 2004, Journal of hepatology.

[26]  K. Koike,et al.  Hepatitis C virus infection and diabetes: direct involvement of the virus in the development of insulin resistance. , 2004, Gastroenterology.

[27]  A. Lonardo,et al.  Steatosis and hepatitis C virus: mechanisms and significance for hepatic and extrahepatic disease. , 2004, Gastroenterology.

[28]  J. Kench,et al.  Insulin resistance is associated with chronic hepatitis C and virus infection fibrosis progression , 2003 .

[29]  David Bernstein,et al.  Impaired IRS‐1/PI3‐kinase signaling in patients with HCV: A mechanism for increased prevalence of type 2 diabetes , 2003, Hepatology.

[30]  Yoshihiko Saito,et al.  Pancreatic beta-cell function and insulin sensitivity in japanese subjects with impaired glucose tolerance and newly diagnosed type 2 diabetes mellitus. , 2003, Metabolism: clinical and experimental.

[31]  A. Geater,et al.  Novel insulin sensitivity index derived from oral glucose tolerance test. , 2003, The Journal of clinical endocrinology and metabolism.

[32]  G. Norkrans,et al.  Steatosis accelerates fibrosis development over time in hepatitis C virus genotype 3 infected patients. , 2002, Journal of hepatology.

[33]  D. Pessayre,et al.  Hepatitis C virus core protein inhibits microsomal triglyceride transfer protein activity and very low density lipoprotein secretion: a model of viral‐related steatosis , 2002, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[34]  M. Szklo,et al.  Prevalence of Type 2 Diabetes Mellitus among Persons with Hepatitis C Virus Infection in the United States , 2000, Annals of Internal Medicine.

[35]  B. Tom,et al.  Further evidence for an association between non–insulin‐dependent diabetes mellitus and chronic hepatitis C virus infection , 1999, Hepatology.

[36]  M. Makuuchi,et al.  Steatosis and intrahepatic hepatitis C virus in chronic hepatitis , 1999, Journal of medical virology.

[37]  N. Turkçapar,et al.  Association of diabetes mellitus and chronic hepatitis C virus infection , 1999, Hepatology.

[38]  M. Matsuda,et al.  Insulin sensitivity indices obtained from oral glucose tolerance testing: comparison with the euglycemic insulin clamp. , 1999, Diabetes care.

[39]  P. Zimmet,et al.  Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1: diagnosis and classification of diabetes mellitus. Provisional report of a WHO Consultation , 1998, Diabetic medicine : a journal of the British Diabetic Association.

[40]  Takao Tsuji,et al.  New Inuyama classification; new criteria for histological assessment of chronic hepatitis , 1996 .

[41]  N Enomoto,et al.  Mutations in the nonstructural protein 5A gene and response to interferon in patients with chronic hepatitis C virus 1b infection. , 1996, The New England journal of medicine.

[42]  T. Sugimura,et al.  Molecular cloning of the human hepatitis C virus genome from Japanese patients with non-A, non-B hepatitis. , 1990, Proceedings of the National Academy of Sciences of the United States of America.

[43]  Neil Kaplowitz,et al.  Formulation and application of a numerical scoring system for assessing histological activity in asymptomatic chronic active hepatitis , 1981, Hepatology.

[44]  M. T. Brennan,et al.  Insulin secretion in response to glycemic stimulus: relation of delayed initial release to carbohydrate intolerance in mild diabetes mellitus. , 1967, The Journal of clinical investigation.

[45]  T. Okanoue,et al.  Steatosis and hepatic expression of genes regulating lipid metabolism in Japanese patients infected with hepatitis C virus , 2009, Journal of Gastroenterology.