One-pot synthesis and anticancer studies of 2-arylamino-5-aryl-1,3,4-thiadiazoles.

[1]  K. Shah,et al.  Synthesis and anticancer activity of 5-(3-indolyl)-1,3,4-thiadiazoles. , 2010, European journal of medicinal chemistry.

[2]  H. Harada,et al.  Synthesis and biological evaluation of indolyl chalcones as antitumor agents. , 2010, Bioorganic & medicinal chemistry letters.

[3]  Daniel J. Freeman,et al.  2-Aminothiadiazole inhibitors of AKT1 as potential cancer therapeutics. , 2010, Bioorganic & medicinal chemistry letters.

[4]  K. Shah,et al.  An expeditious synthesis and anticancer activity of novel 4-(3'-indolyl)oxazoles. , 2010, European journal of medicinal chemistry.

[5]  K. Shah,et al.  An efficient synthesis and biological study of novel indolyl-1,3,4-oxadiazoles as potent anticancer agents. , 2009, Bioorganic & medicinal chemistry letters.

[6]  P. Mishra,et al.  Synthesis of Novel 2,5‐Disubstituted 1,3,4‐Thiadiazoles for Their Potential Anticonvulsant Activity: Pharmacophoric Model Studies , 2009, Archiv der Pharmazie.

[7]  K. Shah,et al.  Synthesis and anticancer activities of novel 3,5-disubstituted-1,2,4-oxadiazoles. , 2009, Bioorganic & medicinal chemistry letters.

[8]  P. Kondaiah,et al.  Synthesis, antimicrobial and cytotoxic activities of 1,3,4-oxadiazoles, 1,3,4-thiadiazoles and 1,2,4-triazoles. , 2009, European journal of medicinal chemistry.

[9]  P. Sahoo,et al.  Synthesis and evaluation of 2-amino-5-sulfanyl-1,3,4-thiadiazoles as antidepressant, anxiolytic, and anticonvulsant agents , 2009, Medicinal Chemistry Research.

[10]  Jie Zhang,et al.  Synthesis and antitumor activity of N1-acetylamino-(5-alkyl/aryl-1,3,4-thiadiazole-2-yl)-5-fluorouracil derivatives , 2008 .

[11]  J. Sainy,et al.  2-Amino-5-sulfanyl-1,3,4-thiadiazoles: A new series of selective cyclooxygenase-2 inhibitors , 2008, Acta pharmaceutica.

[12]  A. Amani,et al.  An efficient one-pot procedure for the preparation of 1,3,4-thiadiazoles in ionic liquid [bmim]BF4 as dual solvent and catalyst , 2008 .

[13]  W. Rzeski,et al.  Anticancer, neuroprotective activities and computational studies of 2-amino-1,3,4-thiadiazole based compound. , 2007, Bioorganic & medicinal chemistry.

[14]  A. Foroumadi,et al.  SYNTHESIS AND ANTICONVULSANT ACTIVITY OF NOVEL 2-AMINO-5-[4-CHLORO-2-(2-CHLOROPHENOXY) PHENYL]-1,3,4-THIADIAZOLE DERIVATIVES , 2007 .

[15]  J. Matysiak,et al.  Synthesis and antiproliferative activity of N-substituted 2-amino-5-(2,4-dihydroxyphenyl)-1,3,4-thiadiazoles. , 2006, Bioorganic & medicinal chemistry.

[16]  M. Świtalska,et al.  Synthesis and antiproliferative activity of some 5-substituted 2-(2,4-dihydroxyphenyl)-1,3,4-thiadiazoles. , 2006, European journal of medicinal chemistry.

[17]  J. Kilburn,et al.  Versatile strategies for the solid phase synthesis of small heterocyclic scaffolds: [1,3,4]-thiadiazoles and [1,3,4]-oxadiazoles , 2005 .

[18]  B. Gierczyk,et al.  SYNTHESIS OF SUBSTITUTED 1,3,4-THIADIAZOLES USING LAWESSON'S REAGENT , 2005 .

[19]  M. Gruttadauria,et al.  Oxidative cyclization of aldehyde thiosemicarbazones induced by potassium ferricyanide and by tris(p-bromophenyl)amino hexachloroantimoniate. A joint experimental and computational study , 2005 .

[20]  Fatma Kandemirli,et al.  1,3,4-thiadiazole derivatives. Synthesis, structure elucidation, and structure-antituberculosis activity relationship investigation. , 2004, Journal of medicinal chemistry.

[21]  R. Frański Electrospray ionization mass spectrometric study of 1,3,4-thiadiazole-copper complexes: comparison with 1,3,4-oxadiazole derivatives. , 2004, Journal of mass spectrometry : JMS.

[22]  J. Earle,et al.  Phase II trials of 5-day vinblastine infusion (NSC 49842), L-alanosine (NSC 153353), acivicin (NSC 163501), and aminothiadiazole (NSC 4728) in patients with recurrent or metastatic renal cell carcinoma , 1988, Investigational new drugs.

[23]  A. Foroumadi,et al.  Synthesis and in vitro antibacterial evaluation of N-[5-(5-nitro-2-thienyl)-1,3,4-thiadiazole-2-yl] piperazinyl quinolones. , 2003, European journal of medicinal chemistry.

[24]  John A Hadfield,et al.  Tubulin and microtubules as targets for anticancer drugs. , 2003, Progress in cell cycle research.

[25]  G. Şener,et al.  Synthesis of new 2,5-disubstituted-1,3,4-thiadiazoles and preliminary evaluation of anticonvulsant and antimicrobial activities. , 2002, Bioorganic & medicinal chemistry.

[26]  E. M. Holt,et al.  Complexes of cobalt(II), nickel(II) and copper(II) with a thia ligand; 2,5-bis(2-pyridyl)-1,3,4-thiadiazole: structural identification , 2002 .

[27]  E. De Clercq,et al.  Synthesis and antiviral activity evaluation of some new 6-substituted 3-(1-adamantyl)-1,2,4-triazolo[3,4-b][1,3,4]thiadiazoles. , 2002, Farmaco.

[28]  F. Bentiss,et al.  Rapid synthesis of 2,5‐disubtituted 1,3,4‐thiadiazoles under microwave irradiation , 2005 .

[29]  D. Lynch,et al.  Tetrakis(2-amino-5-methyl-1,3,4-thiadiazole-N3)chlorocopper(II) chloride monohydrate and tetrakis(2-amino-5-ethyl-1,3,4-thiadiazole-N3)chlorocopper(II) chloride. , 2001, Acta crystallographica. Section C, Crystal structure communications.

[30]  S. Schenone,et al.  3-Arylsulphonyl-5-arylamino-1,3,4-thiadiazol-2(3H)ones as anti-inflammatory and analgesic agents. , 2001, Bioorganic & medicinal chemistry.

[31]  H. Schmidbaur,et al.  The Close-Knit Supramolecular Network of Bis[(tert-butyl isocyanide)gold(I)] 1,3,4-Thiadiazole-2,5-disulfide , 2001 .

[32]  Q. Xue,et al.  Study on 1,3,4-thiadiazole derivatives as novel multifunctional oil additives , 1999 .

[33]  N. Lawrence,et al.  Tubulin as a target for anticancer drugs: Agents which interact with the mitotic spindle , 1998, Medicinal research reviews.

[34]  C. Supuran,et al.  1,3,4-Thiadiazole Derivatives. Part 91. Synthesis and Biological Activity of Metal Complexes of 5-(2-Aminoethyl)-2-Amino-1,3,4-Thiadiazole , 1996, Metal-based drugs.

[35]  K. Mukaida,et al.  Thermotropic liquid-crystalline polymers having five-membered heterocycles as mesogens—2. Homo- and copolymers composed of 1,3- or 1,4-phenylenebis(1,3,4-thiadiazole 2,5-diyl) unit , 1995 .

[36]  T. Maren,et al.  The Development of Topical Carbonic Anhydrase Inhibitors , 1995, Journal of glaucoma.

[37]  M. Gruttadauria,et al.  Substituent effect on oxidative cyclization of aldehyde thiosemicarbazones with ferric chloride , 1991 .

[38]  R. Pape,et al.  Antihypertensive thiadiazoles. 1. Synthesis of some 2-aryl-5-hydrazino-1,3,4-thiadiazoles with vasodilator activity. , 1988, Journal of medicinal chemistry.

[39]  J. A. Nelson,et al.  Mechanism of action of 2-amino-1,3,4-thiadiazole (NSC 4728). , 1977, Cancer research.

[40]  J. A. Nelson,et al.  Effects of 2-amino-1,3,4-thiadiazole on ribonucleotide pools of leukemia L1210 cells. , 1976, Cancer research.