Highly Active and Diastereoselective N,O- and N,N-Yttrium Complexes for Intramolecular Hydroamination

The intramolecular hydroamination of aminoalkynes and unactivated aminoalkenes cata- lyzed by yttrium N,O- and N,N-complexes has been investigated. The N,N-yttrium complexes are highly active, catalyzing the conversion of a wide range of terminal aminoalkenes at room temperature, and in- ternal aminoalkenes at elevated temperature, to yield pyrrolidine and piperidine products in high yields. A high diastereoselectivity of up to 23:1 is ob- served at 08C with 1-methyl-4-pentenylamine as sub- strate.

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