Protein Kinase C-mediated Phosphorylation Does Not Regulate Drug Transport by the Human Multidrug Resistance P-glycoprotein*
暂无分享,去创建一个
C. Higgins | P. McNaughton | A. Sardini | P. Gros | S. Ruetz | R. Callaghan | Hugh R. Goodfellow | Hugh R. Goodfellow | Stephan Ruetz | Richard Callaghan | Peter A. McNaughton | H. R. Goodfellow
[1] I. Pastan,et al. Bacterial expression of the linker region of human MDR1 P-glycoprotein and mutational analysis of phosphorylation sites. , 1995, Biochemistry.
[2] C. Higgins,et al. The ABC of channel regulation , 1995, Cell.
[3] I. Pastan,et al. Effects of phosphorylation of P-glycoprotein on multidrug resistance , 1995, Journal of bioenergetics and biomembranes.
[4] C. Higgins,et al. Protein kinase C‐mediated phosphorylation of the human multidrug resistance P‐glycoprotein regulates cell volume‐activated chloride channels. , 1995, The EMBO journal.
[5] C. Higgins,et al. Drug efflux mediated by the human multidrug resistance P-glycoprotein is inhibited by cell swelling. , 1994, Journal of cell science.
[6] R. Glazer,et al. Modulation of P-glycoprotein by protein kinase C alpha in a baculovirus expression system. , 1994, Biochemistry.
[7] I. Pastan,et al. GTP-stimulated phosphorylation of P-glycoprotein in transporting vesicles from KB-V1 multidrug resistant cells. , 1994, Biochemistry.
[8] J. Wine,et al. Selection for MDR1/P-glycoprotein enhances swelling-activated K+ and Cl- currents in NIH/3T3 cells. , 1994, The American journal of physiology.
[9] P. Gros,et al. Functional expression of P-glycoproteins in secretory vesicles. , 1994, The Journal of biological chemistry.
[10] T. Chambers,et al. Phosphorylation by protein kinase C and cyclic AMP-dependent protein kinase of synthetic peptides derived from the linker region of human P-glycoprotein. , 1994, The Biochemical journal.
[11] E. Nieves,et al. Identification of the major phosphorylation domain of murine mdr1b P-glycoprotein. Analysis of the protein kinase A and protein kinase C phosphorylation sites. , 1993, The Journal of biological chemistry.
[12] I. Pastan,et al. Fluorescent cellular indicators are extruded by the multidrug resistance protein. , 1993, The Journal of biological chemistry.
[13] S. Bates,et al. Differential modulation of P-glycoprotein transport by protein kinase inhibition. , 1993, Biochemistry.
[14] J. Riordan,et al. Synthetic and natural opiates interact with P-glycoprotein in multidrug-resistant cells. , 1993, The Journal of biological chemistry.
[15] K. Kohno,et al. Involvement of protein kinase in environmental stress‐induced activation of human multidrug resistance 1 (MDR1) gene promoter , 1993, FEBS letters.
[16] T. Chambers,et al. Identification of specific sites in human P-glycoprotein phosphorylated by protein kinase C. , 1993, The Journal of biological chemistry.
[17] T. Hasegawa,et al. Staurosporine derivatives reverse multidrug resistance without correlation with their protein kinase inhibitory activities. , 1993, The Journal of antibiotics.
[18] I. Abraham,et al. Staurosporine reduces P-glycoprotein expression and modulates multidrug resistance. , 1993, Cancer letters.
[19] D. Fabbro,et al. Selective regulation of expression of protein kinase C (PKC) isoenzymes in multidrug-resistant MCF-7 cells. Functional significance of enhanced expression of PKC alpha. , 1993, The Journal of biological chemistry.
[20] T. Hasegawa,et al. Effect of Staurosporine Derivatives on Protein Kinase Activity and Vinblastine Accumulation in Mouse Leukaemia P388/ADR Cells , 1993, The Journal of pharmacy and pharmacology.
[21] K. Takeda,et al. Increase of vinblastine accumulation by inhibitors of calmodulin-dependent cell functions in rat ascites hepatoma AH66 cells. , 1992, Anticancer research.
[22] C. Higgins,et al. Separation of drug transport and chloride channel functions of the human multidrug resistance P-glycoprotein , 1992, Cell.
[23] S. Bates,et al. Modulation of P-glycoprotein phosphorylation and drug transport by sodium butyrate. , 1992, Biochemistry.
[24] J. Karaszkiewicz,et al. Elevated level of nuclear protein kinase C in multidrug-resistant MCF-7 human breast carcinoma cells. , 1992, Cancer research.
[25] I. Pastan,et al. Reduced mRNA levels for the multidrug‐resistance genes in cAMP‐dependent protein kinase mutant cell lines , 1992, Journal of cellular physiology.
[26] K. Takagi,et al. Reversal of vinblastine resistance by a new staurosporine derivative, NA-382, in P388/ADR cells. , 1992, Cancer letters.
[27] T. Chambers,et al. Regulation by phorbol ester and protein kinase C inhibitors, and by a protein phosphatase inhibitor (okadaic acid), of P-glycoprotein phosphorylation and relationship to drug accumulation in multidrug-resistant human KB cells. , 1992, Molecular pharmacology.
[28] M. Valverde,et al. Volume-regulated chloride channels associated with the human multidrug-resistance P-glycoprotein , 1992, Nature.
[29] K. Suzuki,et al. Transfection with protein kinase C alpha confers increased multidrug resistance to MCF-7 cells expressing P-glycoprotein. , 1991, Cancer communications.
[30] L. Takemoto,et al. Analysis of P-glycoprotein phosphorylation in HL60 cells isolated for resistance to vincristine. , 1991, The Journal of biological chemistry.
[31] T. Tsuruo,et al. Staurosporine, a potent inhibitor of C-kinase, enhances drug accumulation in multidrug-resistant cells. , 1990, Biochemical and biophysical research communications.
[32] M. Gottesman,et al. Transfection of a mutant regulatory subunit gene of cAMP-dependent protein kinase causes increased drug sensitivity and decreased expression of P-glycoprotein. , 1990, Experimental cell research.
[33] T. Chambers,et al. Protein kinase C phosphorylates P-glycoprotein in multidrug resistant human KB carcinoma cells. , 1990, The Journal of biological chemistry.
[34] D. Marquardt,et al. Characterization of a membrane-associated protein kinase of multidrug-resistant HL60 cells which phosphorylates P-glycoprotein. , 1990, The Journal of biological chemistry.
[35] L. Tsui,et al. Erratum: Identification of the Cystic Fibrosis Gene: Cloning and Characterization of Complementary DNA , 1989, Science.
[36] O. Elroy-Stein,et al. Cap-independent translation of mRNA conferred by encephalomyocarditis virus 5' sequence improves the performance of the vaccinia virus/bacteriophage T7 hybrid expression system. , 1989, Proceedings of the National Academy of Sciences of the United States of America.
[37] I. Fidler,et al. Level of protein kinase C activity correlates directly with resistance to adriamycin in murine fibrosarcoma cells , 1989, FEBS letters.
[38] W. Hait,et al. Inhibition of protein kinase C by antineoplastic agents: implications for drug resistance. , 1987, Biochemical and biophysical research communications.
[39] N. Walworth,et al. Purification and characterization of constitutive secretory vesicles from yeast , 1987, The Journal of cell biology.
[40] J. Riordan,et al. Action of calcium antagonists on multidrug resistant cells. Specific cytotoxicity independent of increased cancer drug accumulation. , 1987, Biochemical pharmacology.
[41] B. Moss,et al. Eukaryotic transient-expression system based on recombinant vaccinia virus that synthesizes bacteriophage T7 RNA polymerase. , 1986, Proceedings of the National Academy of Sciences of the United States of America.
[42] Y. Fujiki,et al. Isolation of intracellular membranes by means of sodium carbonate treatment: application to endoplasmic reticulum , 1982, The Journal of cell biology.
[43] H. Towbin,et al. Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications. , 1979, Proceedings of the National Academy of Sciences of the United States of America.
[44] J. Till,et al. Modulation of drug permeability in Chinese hamster ovary cells. Possible role for phosphorylation of surface glycoproteins. , 1977, Biochimica et biophysica acta.
[45] U. K. Laemmli,et al. Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4 , 1970, Nature.
[46] I. Pastan,et al. Biochemistry of multidrug resistance mediated by the multidrug transporter. , 1993, Annual review of biochemistry.
[47] I. Fidler,et al. Stable expression of a cDNA encoding rat brain protein kinase C-beta I confers a multidrug-resistant phenotype on rat fibroblasts. , 1992, Anticancer research.
[48] Chaudhary Pm,et al. Activation of MDR1 (P-glycoprotein) gene expression in human cells by protein kinase C agonists. , 1992 .
[49] M. Gottesman,et al. Is the multidrug transporter a flippase? , 1992, Trends in biochemical sciences.
[50] R. Fine,et al. Phorbol esters induce multidrug resistance in human breast cancer cells. , 1988, Proceedings of the National Academy of Sciences of the United States of America.
[51] T. Vernet,et al. A family of yeast expression vectors containing the phage f1 intergenic region. , 1987, Gene.