WNT-dependent interaction between inflammatory fibroblasts and FOLR2+ macrophages promotes fibrosis in chronic kidney disease

[1]  A. Pisco,et al.  Indian Hedgehog release from TNF-activated renal epithelia drives local and remote organ fibrosis , 2023, Science Translational Medicine.

[2]  C. Li,et al.  Pan-cancer single-cell analysis reveals the heterogeneity and plasticity of cancer-associated fibroblasts in the tumor microenvironment , 2022, Nature Communications.

[3]  Zhi Yang,et al.  CXCL12/CXCR4: An amazing challenge and opportunity in the fight against fibrosis , 2022, Ageing Research Reviews.

[4]  J. Elstrott,et al.  LRRC15+ myofibroblasts dictate the stromal setpoint to suppress tumour immunity , 2022, Nature.

[5]  Zeguo Sun,et al.  The single-cell landscape of kidney immune cells reveals transcriptional heterogeneity in early diabetic kidney disease. , 2022, Kidney international.

[6]  K. Kessenbrock,et al.  Wound healing in aged skin exhibits systems-level alterations in cellular composition and cell-cell communication , 2022, Cell reports.

[7]  Youhua Liu,et al.  The fibrogenic niche in kidney fibrosis: components and mechanisms , 2022, Nature Reviews Nephrology.

[8]  M. Breyer,et al.  Mapping the single-cell transcriptomic response of murine diabetic kidney disease to therapies. , 2022, Cell metabolism.

[9]  Junhyong Kim,et al.  Single-cell analysis identifies the interaction of altered renal tubules with basophils orchestrating kidney fibrosis , 2022, Nature Immunology.

[10]  I. Buvat,et al.  Fibroblast heterogeneity in solid tumors: from single cell analysis to whole-body imaging. , 2022, Seminars in cancer biology.

[11]  C. Danko,et al.  Cell type and gene expression deconvolution with BayesPrism enables Bayesian integrative analysis across bulk and single-cell RNA sequencing in oncology , 2022, Nature Cancer.

[12]  F. Ginhoux,et al.  Tissue-resident FOLR2+ macrophages associate with CD8+ T cell infiltration in human breast cancer , 2022, Cell.

[13]  F. Buettner,et al.  Inflammatory fibroblasts mediate resistance to neoadjuvant therapy in rectal cancer. , 2022, Cancer cell.

[14]  M. Gerstung,et al.  Cell2location maps fine-grained cell types in spatial transcriptomics , 2022, Nature Biotechnology.

[15]  E. Olson,et al.  Defining cellular complexity in human autosomal dominant polycystic kidney disease by multimodal single cell analysis , 2021, bioRxiv.

[16]  M. Mino‐Kenudson,et al.  Three subtypes of lung cancer fibroblasts define distinct therapeutic paradigms. , 2021, Cancer cell.

[17]  Stephen R. Williams,et al.  A single-cell and spatially resolved atlas of human breast cancers , 2021, Nature Genetics.

[18]  Jun Xie,et al.  The Role of Macrophages in Kidney Fibrosis , 2021, Frontiers in Physiology.

[19]  C. Jørgensen,et al.  Single-cell analysis defines a pancreatic fibroblast lineage that supports anti-tumor immunity , 2021, Cancer cell.

[20]  A. Sanz,et al.  Role of Macrophages and Related Cytokines in Kidney Disease , 2021, Frontiers in Medicine.

[21]  E. Kenigsberg,et al.  Tissue-resident macrophages provide a pro-tumorigenic niche to early NSCLC cells , 2021, Nature.

[22]  F. Mechta-Grigoriou,et al.  Role of cancer‐associated fibroblast subpopulations in immune infiltration, as a new means of treatment in cancer , 2021, Immunological reviews.

[23]  R. Schwabe,et al.  Promotion of cholangiocarcinoma growth by diverse cancer-associated fibroblast subpopulations. , 2021, Cancer cell.

[24]  Junedh M. Amrute,et al.  Spatial multi-omic map of human myocardial infarction , 2020, Nature.

[25]  Victor G. Puelles,et al.  Decoding myofibroblast origins in human kidney fibrosis , 2020, Nature.

[26]  T. Wynn,et al.  Fibrosis: from mechanisms to medicines , 2020, Nature.

[27]  Raphael Gottardo,et al.  Integrated analysis of multimodal single-cell data , 2020, Cell.

[28]  D. Fliser,et al.  WNT–β-catenin signalling — a versatile player in kidney injury and repair , 2020, Nature Reviews Nephrology.

[29]  X. Liu,et al.  Stromal cell diversity associated with immune evasion in human triple‐negative breast cancer , 2020, The EMBO journal.

[30]  A. Vincent-Salomon,et al.  A subset of activated fibroblasts is associated with distant relapse in early luminal breast cancer , 2020, Breast Cancer Research.

[31]  D. Tuveson,et al.  DIVERSITY AND BIOLOGY OF CANCER-ASSOCIATED FIBROBLASTS. , 2020, Physiological reviews.

[32]  S. Teichmann,et al.  Single-Cell RNA Sequencing Reveals a Dynamic Stromal Niche That Supports Tumor Growth , 2020, Cell reports.

[33]  S. Byers,et al.  Single-Cell Transcriptomic Analysis of Tumor-Derived Fibroblasts and Normal Tissue-Resident Fibroblasts Reveals Fibroblast Heterogeneity in Breast Cancer , 2020, Cancers.

[34]  K. Modarage,et al.  The Role of Wnt Signalling in Chronic Kidney Disease (CKD) , 2020, Genes.

[35]  A. Vincent-Salomon,et al.  Cancer-associated fibroblast heterogeneity in axillary lymph nodes drives metastases in breast cancer through complementary mechanisms , 2020, Nature Communications.

[36]  Sarah A. Boswell,et al.  Multi omics analysis of fibrotic kidneys in two mouse models , 2019, Scientific Data.

[37]  S. Raychaudhuri,et al.  Distinct fibroblast subsets drive inflammation and damage in arthritis , 2019, Nature.

[38]  P. Spellman,et al.  Human Tumor-Associated Macrophage and Monocyte Transcriptional Landscapes Reveal Cancer-Specific Reprogramming, Biomarkers, and Therapeutic Targets , 2019, Cancer cell.

[39]  Nir Hacohen,et al.  Defining inflammatory cell states in rheumatoid arthritis joint synovial tissues by integrating single-cell transcriptomics and mass cytometry , 2019, Nature Immunology.

[40]  H. Lan,et al.  Macrophages: versatile players in renal inflammation and fibrosis , 2019, Nature Reviews Nephrology.

[41]  Andrew J. Hill,et al.  The single cell transcriptional landscape of mammalian organogenesis , 2019, Nature.

[42]  Åsa K. Björklund,et al.  Spatially and functionally distinct subclasses of breast cancer-associated fibroblasts revealed by single cell RNA sequencing , 2018, Nature Communications.

[43]  Youhua Liu,et al.  New insights into the role and mechanism of Wnt/β‐catenin signalling in kidney fibrosis , 2018, Nephrology.

[44]  J. Sáez-Rodríguez,et al.  Benchmark and integration of resources for the estimation of human transcription factor activities , 2018, bioRxiv.

[45]  B. Humphreys,et al.  Meis1 is specifically upregulated in kidney myofibroblasts during aging and injury but is not required for kidney homeostasis or fibrotic response. , 2018, American journal of physiology. Renal physiology.

[46]  Paul J. Hoover,et al.  An eQTL landscape of kidney tissue in human nephrotic syndrome , 2018, bioRxiv.

[47]  A. Vincent-Salomon,et al.  miR200-regulated CXCL12β promotes fibroblast heterogeneity and immunosuppression in ovarian cancers , 2018, Nature Communications.

[48]  Inna Kuperstein,et al.  Fibroblast Heterogeneity and Immunosuppressive Environment in Human Breast Cancer. , 2018, Cancer cell.

[49]  Nir Hacohen,et al.  Functionally distinct disease-associated fibroblast subsets in rheumatoid arthritis , 2018, Nature Communications.

[50]  H. Yao,et al.  CD10+GPR77+ Cancer-Associated Fibroblasts Promote Cancer Formation and Chemoresistance by Sustaining Cancer Stemness , 2018, Cell.

[51]  K. Mak,et al.  Basement Membrane Type IV Collagen and Laminin: An Overview of Their Biology and Value as Fibrosis Biomarkers of Liver Disease , 2017, Anatomical record.

[52]  R. Hynes,et al.  Characterization of the Extracellular Matrix of Normal and Diseased Tissues Using Proteomics. , 2017, Journal of proteome research.

[53]  D. Tuveson,et al.  Br Ief Definitive Repor T , 2022 .

[54]  C. Guha,et al.  Macrophage-derived extracellular vesicle-packaged WNTs rescue intestinal stem cells and enhance survival after radiation injury , 2016, Nature Communications.

[55]  J. Cruzado,et al.  Macrophage in chronic kidney disease , 2016, Clinical kidney journal.

[56]  Genichiro Ishii,et al.  Phenotypic and functional heterogeneity of cancer-associated fibroblast within the tumor microenvironment. , 2016, Advanced drug delivery reviews.

[57]  K. Shedden,et al.  Tissue transcriptome-driven identification of epidermal growth factor as a chronic kidney disease biomarker , 2015, Science Translational Medicine.

[58]  S. Weiss,et al.  Snail1-induced partial epithelial-to-mesenchymal transition drives renal fibrosis in mice and can be targeted to reverse established disease , 2015, Nature Medicine.

[59]  R. Kalluri,et al.  Epithelial to Mesenchymal Transition induces cell cycle arrest and parenchymal damage in renal fibrosis , 2015, Nature Medicine.

[60]  Jung Eun Shim,et al.  TRRUST: a reference database of human transcriptional regulatory interactions , 2015, Scientific Reports.

[61]  B. Ebert,et al.  Perivascular Gli1+ progenitors are key contributors to injury-induced organ fibrosis. , 2015, Cell stem cell.

[62]  R. Kramann,et al.  Kidney pericytes: roles in regeneration and fibrosis. , 2014, Seminars in nephrology.

[63]  R. Kramann,et al.  Understanding the origin, activation and regulation of matrix‐producing myofibroblasts for treatment of fibrotic disease , 2013, The Journal of pathology.

[64]  J. Duffield,et al.  Wnt signalling in kidney diseases: dual roles in renal injury and repair , 2013, The Journal of pathology.

[65]  Chrysta Lienczewski,et al.  Design of the Nephrotic Syndrome Study Network (NEPTUNE) to evaluate primary glomerular nephropathy by a multi-disciplinary approach , 2012, Kidney international.

[66]  B. Thornhill,et al.  Fight-or-flight: murine unilateral ureteral obstruction causes extensive proximal tubular degeneration, collecting duct dilatation, and minimal fibrosis. , 2012, American journal of physiology. Renal physiology.

[67]  H. Anders,et al.  Renal microenvironments and macrophage phenotypes determine progression or resolution of renal inflammation and fibrosis. , 2011, Kidney international.

[68]  Soo Young Lee,et al.  Cadherin-11 regulates fibroblast inflammation , 2011, Proceedings of the National Academy of Sciences.

[69]  Jie J. Zheng,et al.  Macrophage Wnt7b is critical for kidney repair and regeneration , 2010, Proceedings of the National Academy of Sciences.

[70]  L. Williams,et al.  Discovery of a Cytokine and Its Receptor by Functional Screening of the Extracellular Proteome , 2008, Science.

[71]  Mark W. Kieran,et al.  Identification of fibroblast heterogeneity in the tumor microenvironment , 2006, Cancer biology & therapy.

[72]  A. McMahon,et al.  Fate tracing reveals the pericyte and not epithelial origin of myofibroblasts in kidney fibrosis. , 2010, The American journal of pathology.

[73]  C. Cohen,et al.  Quantitative gene expression analysis in renal biopsies: a novel protocol for a high-throughput multicenter application. , 2002, Kidney international.

[74]  M. De Ley,et al.  Homogeneous interferon-inducing 22K factor is related to endogenous pyrogen and interleukin-1 , 1985, Nature.