PERV inactivation is necessary to guarantee absence of pig‐to‐patient PERVs transmission in xenotransplantation

wileyonlinelibrary.com/journal/xen | 1 of 4 https://doi.org/10.1111/xen.12366 © 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd. In this issue of xenotransplantation, Scobie et al. commented on our recent production of PERVinactivated pigs using CRISPRcas9.1 Based on the data of our studies, we believe there is an unneglectable risk of pigtohuman PERV transmission. We would like to provide some remarks and share our opinions about this issue here. In a previous commentary on xenotransplantation, Joachim Denner has warned that PERV is the main microbiological risk for Received: 30 October 2017 | Accepted: 30 October 2017 DOI: 10.1111/xen.12366

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