Cytochrome b5 impacts on cytochrome P450-mediated metabolism of benzo[a]pyrene and its DNA adduct formation: studies in hepatic cytochrome b5/P450 reductase null (HBRN) mice

[1]  P. White,et al.  Benchmark dose analyses of multiple genetic toxicity endpoints permit robust, cross-tissue comparisons of MutaMouse responses to orally delivered benzo[a]pyrene , 2017, Archives of Toxicology.

[2]  Yang Luan,et al.  Detoxification of benzo[a]pyrene primarily depends on cytochrome P450, while bioactivation involves additional oxidoreductases including 5‐lipoxygenase, cyclooxygenase, and aldo‐keto reductase in the liver , 2017, Journal of biochemical and molecular toxicology.

[3]  V. Arlt,et al.  NADH:Cytochrome b5 Reductase and Cytochrome b5 Can Act as Sole Electron Donors to Human Cytochrome P450 1A1-Mediated Oxidation and DNA Adduct Formation by Benzo[a]pyrene , 2016, Chemical research in toxicology.

[4]  M. Stratton,et al.  Mutational signatures associated with tobacco smoking in human cancer , 2016, Science.

[5]  V. Arlt,et al.  NADPH- and NADH-dependent metabolism of and DNA adduct formation by benzo[a]pyrene catalyzed with rat hepatic microsomes and cytochrome P450 1A1 , 2016, Monatshefte für Chemie - Chemical Monthly.

[6]  P. White,et al.  Tissue-specific in vivo genetic toxicity of nine polycyclic aromatic hydrocarbons assessed using the Muta™Mouse transgenic rodent assay , 2016, Toxicology and applied pharmacology.

[7]  C. Yauk,et al.  Comparative transcriptomic analyses to scrutinize the assumption that genotoxic PAHs exert effects via a common mode of action , 2015, Archives of Toxicology.

[8]  V. Arlt,et al.  The impact of p53 on DNA damage and metabolic activation of the environmental carcinogen benzo[a]pyrene: effects in Trp53(+/+), Trp53(+/–) and Trp53(−/−) mice , 2015, Archives of Toxicology.

[9]  V. Arlt,et al.  The Hepatic Reductase Null (HRN™) and Reductase Conditional Null (RCN) mouse models as suitable tools to study metabolism, toxicity and carcinogenicity of environmental pollutants , 2015 .

[10]  V. Arlt,et al.  Pulmonary Inflammation Impacts on CYP1A1-Mediated Respiratory Tract DNA Damage Induced by the Carcinogenic Air Pollutant Benzo[a]pyrene , 2015, Toxicological sciences : an official journal of the Society of Toxicology.

[11]  P. White,et al.  TP53 mutations induced by BPDE in Xpa-WT and Xpa-Null human TP53 knock-in (Hupki) mouse embryo fibroblasts , 2015, Mutation research.

[12]  Radek,et al.  carcinogen benzo [ a ] pyrene : effects in Trp 53 ( + / + ) , Trp 53 ( + /-) and Trp 53 (-/-) mice , 2015 .

[13]  J. Kucab,et al.  Carcinogenic polycyclic aromatic hydrocarbons induce CYP1A1 in human cells via a p53-dependent mechanism , 2014, Archives of Toxicology.

[14]  V. Arlt,et al.  Cytochrome b5 and epoxide hydrolase contribute to benzo[a]pyrene-DNA adduct formation catalyzed by cytochrome P450 1A1 under low NADPH:P450 oxidoreductase conditions. , 2014, Toxicology.

[15]  D. Nebert,et al.  Oral Benzo[a]pyrene: Understanding Pharmacokinetics, Detoxication, and Consequences—Cyp1 Knockout Mouse Lines as a Paradigm , 2013, Molecular Pharmacology.

[16]  C. Wolf,et al.  Evidence That Cytochrome b5 and Cytochrome b5 Reductase Can Act as Sole Electron Donors to the Hepatic Cytochrome P450 System , 2013, Molecular Pharmacology.

[17]  I. Blair,et al.  Identification of Stable Benzo[a]pyrene-7,8-dione-DNA Adducts in Human Lung Cells , 2013, Chemical research in toxicology.

[18]  V. Arlt,et al.  ³²P-postlabeling analysis of DNA adducts. , 2013, Methods in molecular biology.

[19]  C. Wolf,et al.  Evidence That Cytochrome b 5 and Cytochrome b 5 Reductase Can Act as Sole Electron Donors to the Hepatic Cytochrome P 450 System s , 2013 .

[20]  S. Venitt,et al.  DNA and protein adducts in human tissues resulting from exposure to tobacco smoke , 2012, International journal of cancer.

[21]  David E. Williams,et al.  Polycyclic aromatic hydrocarbons as skin carcinogens: comparison of benzo[a]pyrene, dibenzo[def,p]chrysene and three environmental mixtures in the FVB/N mouse. , 2012, Toxicology and applied pharmacology.

[22]  V. Arlt,et al.  Exposure to benzo[a]pyrene of Hepatic Cytochrome P450 Reductase Null (HRN) and P450 Reductase Conditional Null (RCN) mice: Detection of benzo[a]pyrene diol epoxide-DNA adducts by immunohistochemistry and 32P-postlabelling. , 2012, Toxicology letters.

[23]  Andrew Williams,et al.  Subchronic Oral Exposure to Benzo(a)pyrene Leads to Distinct Transcriptomic Changes in the Lungs That Are Related to Carcinogenesis , 2012, Toxicological sciences : an official journal of the Society of Toxicology.

[24]  F. Guengerich,et al.  Contributions of human enzymes in carcinogen metabolism. , 2012, Chemical research in toxicology.

[25]  J. Kucab,et al.  Metabolic activation of diesel exhaust carcinogens in primary and immortalized human TP53 knock‐in (Hupki) mouse embryo fibroblasts , 2012, Environmental and molecular mutagenesis.

[26]  David H Phillips,et al.  Bioactivation versus detoxication of the urothelial carcinogen aristolochic acid I by human cytochrome P450 1A1 and 1A2. , 2012, Toxicological sciences : an official journal of the Society of Toxicology.

[27]  V. Arlt,et al.  Effect of Hepatic Cytochrome P450 (P450) Oxidoreductase Deficiency on 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine-DNA Adduct Formation in P450 Reductase Conditional Null Mice , 2011, Drug Metabolism and Disposition.

[28]  V. Arlt,et al.  Role of P450 1A1 and P450 1A2 in bioactivation versus detoxication of the renal carcinogen aristolochic acid I: studies in Cyp1a1-/-, Cyp1a2-/-, and Cyp1a1/1a2-/- mice. , 2011, Chemical research in toxicology.

[29]  D. Nebert,et al.  Organ-Specific Roles of CYP1A1 during Detoxication of Dietary Benzo[a]pyrene , 2010, Molecular Pharmacology.

[30]  R. Finn,et al.  Defining the in Vivo Role for Cytochrome b5 in Cytochrome P450 Function through the Conditional Hepatic Deletion of Microsomal Cytochrome b5*S⃞ , 2008, Journal of Biological Chemistry.

[31]  V. Arlt,et al.  Metabolic activation of benzo[a]pyrene in vitro by hepatic cytochrome P450 contrasts with detoxification in vivo : experiments with Hepatic Cytochrome P450 Reductase Null mice , 2008 .

[32]  F. Guengerich.  Cytochrome p450 and chemical toxicology. , 2008, Chemical research in toxicology.

[33]  Ingrid V. Botnen,et al.  Quantitative analysis of benzo[a]pyrene biotransformation and adduct formation in Ahr knockout mice. , 2006, Toxicology letters.

[34]  D. Nebert,et al.  The role of cytochrome P450 enzymes in endogenous signalling pathways and environmental carcinogenesis , 2006, Nature Reviews Cancer.

[35]  D. Nebert,et al.  Oral Benzo[a]pyrene in Cyp1 Knockout Mouse Lines: CYP1A1 Important in Detoxication, CYP1B1 Metabolism Required for Immune Damage Independent of Total-Body Burden and Clearance Rate , 2006, Molecular Pharmacology.

[36]  C. Wolf,et al.  The hepatic cytochrome P450 reductase null mouse as a tool to identify a successful candidate entity. , 2006, Toxicology letters.

[37]  I. Blair,et al.  Competing roles of aldo-keto reductase 1A1 and cytochrome P4501B1 in benzo[a]pyrene-7,8-diol activation in human bronchoalveolar H358 cells: role of AKRs in P4501B1 induction. , 2006, Chemical research in toxicology.

[38]  A. Luch,et al.  Metabolic Activation and Detoxification of Polycyclic Aromatic Hydrocarbons , 2005 .

[39]  Václav Martínek,et al.  Expression of cytochrome P450 1A1 and its contribution to oxidation of a potential human carcinogen 1-phenylazo-2-naphthol (Sudan I) in human livers. , 2005, Cancer letters.

[40]  Trevor M Penning,et al.  Competing roles of cytochrome P450 1A1/1B1 and aldo-keto reductase 1A1 in the metabolic activation of (+/-)-7,8-dihydroxy-7,8-dihydro-benzo[a]pyrene in human bronchoalveolar cell extracts. , 2005, Chemical research in toxicology.

[41]  D. Phillips.  Macromolecular adducts as biomarkers of human exposure to polycyclic aromatic hydrocarbons. , 2005 .

[42]  V. Arlt,et al.  32P-postlabeling analysis of DNA adducts. , 2005, Methods in molecular biology.

[43]  B. Mahadevan,et al.  Carcinogenic polycyclic aromatic hydrocarbon‐DNA adducts and mechanism of action , 2005, Environmental and molecular mutagenesis.

[44]  D. Nebert,et al.  Oral exposure to benzo[a]pyrene in the mouse: detoxication by inducible cytochrome P450 is more important than metabolic activation. , 2004, Molecular pharmacology.

[45]  P. Swiatek,et al.  Conditional knockout of the mouse NADPH‐cytochrome p450 reductase gene , 2003, Genesis.

[46]  V. Arlt,et al.  Human enzymes involved in the metabolic activation of the environmental contaminant 3-nitrobenzanthrone: evidence for reductive activation by human NADPH:cytochrome p450 reductase. , 2003, Cancer research.

[47]  C. Wolf,et al.  Inactivation of the Hepatic Cytochrome P450 System by Conditional Deletion of Hepatic Cytochrome P450 Reductase* , 2003, The Journal of Biological Chemistry.

[48]  J. Ward,et al.  Carcinogenesis of the food mutagen PhIP in mice is independent of CYP1A2. , 2003, Carcinogenesis.

[49]  P. Fernández-Salguero,et al.  Polycyclic aromatic hydrocarbon‐inducible DNA adducts: Evidence by 32P‐postlabeling and use of knockout mice for Ah receptor‐independent mechanisms of metabolic activation in vivo , 2003, International journal of cancer.

[50]  Marie Stiborová,et al.  Sudan I is a potential carcinogen for humans: evidence for its metabolic activation and detoxication by human recombinant cytochrome P450 1A1 and liver microsomes. , 2002, Cancer research.

[51]  A. Luch,et al.  Cytochrome P450 1B1 determines susceptibility to dibenzo[a,l]pyrene-induced tumor formation. , 2002, Chemical research in toxicology.

[52]  H. Yamazaki,et al.  Roles of NADPH-P450 reductase and apo- and holo-cytochrome b5 on xenobiotic oxidations catalyzed by 12 recombinant human cytochrome P450s expressed in membranes of Escherichia coli. , 2002, Protein expression and purification.

[53]  D. Warshawsky,et al.  Benzo[a]pyrene-induced toxicity: paradoxical protection in Cyp1a1(-/-) knockout mice having increased hepatic BaP-DNA adduct levels. , 2001, Biochemical and biophysical research communications.

[54]  R. Gupta,et al.  Identification and characterization of a novel benzo[a]pyrene-derived DNA adduct. , 2001, Biochemical and biophysical research communications.

[55]  P. Thompson,et al.  Carcinogen substrate specificity of human COX-1 and COX-2. , 2001, Carcinogenesis.

[56]  J. Ward,et al.  CYP1A2 is not the primary enzyme responsible for 4-aminobiphenyl-induced hepatocarcinogenesis in mice. , 1999, Carcinogenesis.

[57]  D. Phillips,et al.  Polycyclic aromatic hydrocarbons in the diet. , 1999, Mutation research.

[58]  T. Mikami,et al.  Toxicity profile of benzo[a]pyrene in the male LacZ transgenic mouse (MutaMouse) following oral administration for 5 consecutive days. , 1998, Regulatory toxicology and pharmacology : RTP.

[59]  H. Yamazaki,et al.  Requirements for cytochrome b5 in the oxidation of 7-ethoxycoumarin, chlorzoxazone, aniline, and N-nitrosodimethylamine by recombinant cytochrome P450 2E1 and by human liver microsomes. , 1996, Biochemical pharmacology.

[60]  H. Yamazaki,et al.  Roles of Cytochrome b5in the Oxidation of Testosterone and Nifedipine by Recombinant Cytochrome P450 3A4 and by Human Liver Microsomes , 1996 .

[61]  S. Nesnow,et al.  Quantitative and temporal relationships between DNA adduct formation in target and surrogate tissues: implications for biomonitoring. , 1993, Environmental health perspectives.

[62]  L. Marnett.  Prostaglandin synthase-mediated metabolism of carcinogens and a potential role for peroxyl radicals as reactive intermediates. , 1990, Environmental Health Perspectives.

[63]  D. Phillips,et al.  32P-postlabelling analysis of DNA adducts of benzo[a]pyrene formed in complex metabolic activation systems in vitro. , 1989, Cancer letters.

[64]  G. Ginsberg,et al.  Transport of DNA-adducting metabolites in mouse serum following benzo[a]pyrene administration. , 1989, Carcinogenesis.

[65]  J. Horton,et al.  Quantitation of benzo(a)pyrene metabolite: DNA adducts in selected hepatic and pulmonary cell types isolated from [3H]benzo(a)pyrene-treated rabbits. , 1985, Cancer research.

[66]  S. Sebti,et al.  Benzo[a]pyrene--DNA adduct formation in target cells in a cell-mediated mutation assay. , 1982, Carcinogenesis.

[67]  R. Estabrook,et al.  Evidence for the participation of cytochrome b 5 in hepatic microsomal mixed-function oxidation reactions. , 1971, Archives of biochemistry and biophysics.