Biomedical applications of additive manufacturing: Present and future

Abstract Three dimensional printing (3DP) or additive manufacturing (AM) of medical devices and scaffolds for tissue engineering, regenerative medicine, ex-vivo tissues and drug delivery is of intense interest in recent years. A few medical devices namely, ZipDose ® , Pharmacoprinting, powder bed fusion, HPAM™, bio-printer and inkjet printer received FDA clearance while several biomedical applications are being developed. This paper reviews influence of type of AM method and process parameters on the surface topography, geometrical features, mechanical properties, biocompatibility, in vitro, and in vivo performance of diverse orthopedic applications. Attempts have been made to identify gaps, suggest ideas for future developments, and to emphasis the need of standardization.

[1]  Liciane Sabadin Bertol,et al.  Dimensional evaluation of patient-specific 3D printing using calcium phosphate cement for craniofacial bone reconstruction , 2017, Journal of biomaterials applications.

[2]  Anders Snis,et al.  Effect of process parameters settings and thickness on surface roughness of EBM produced Ti‐6Al‐4V , 2012 .

[3]  David Z. Zhang,et al.  Additive manufacturing: A framework for implementation , 2014 .

[4]  Chi-Mun Cheah,et al.  Integration of laser surface digitizing with CAD/CAM techniques for developing facial prostheses. Part 1: Design and fabrication of prosthesis replicas. , 2003, The International journal of prosthodontics.

[5]  Rupinder Singh,et al.  Investigating the surface roughness of implant prepared by combining fused deposition modeling and investment casting , 2016 .

[6]  Luca Facchini,et al.  Microstructure and mechanical properties of Ti‐6Al‐4V produced by electron beam melting of pre‐alloyed powders , 2009 .

[7]  Kamran Mumtaz,et al.  Top surface and side roughness of Inconel 625 parts processed using selective laser melting , 2009 .

[8]  Shamsudin Shamsul Anuar,et al.  Effect Of Part Features On Dimensional Accuracy Of FDM Model , 2016 .

[9]  Ming-Chuan Leu,et al.  Additive manufacturing: technology, applications and research needs , 2013, Frontiers of Mechanical Engineering.

[10]  Robert L. Mason,et al.  Fatigue Life of Titanium Alloys Fabricated by Additive Layer Manufacturing Techniques for Dental Implants , 2013, Metallurgical and Materials Transactions A.

[11]  Timothy J Horn,et al.  Overview of Current Additive Manufacturing Technologies and Selected Applications , 2012, Science progress.

[13]  U. Glatzel,et al.  Microstructure and mechanical properties of selective laser melted Inconel 718 compared to forging and casting , 2016 .

[14]  R. Singer,et al.  Cellular Ti-6Al-4V structures with interconnected macro porosity for bone implants fabricated by selective electron beam melting. , 2008, Acta biomaterialia.

[15]  R. Venkata Rao,et al.  Optimization of fused deposition modeling process using teaching-learning-based optimization algorithm , 2016 .

[16]  J. Kruth,et al.  Effects of build orientation and heat treatment on the microstructure and mechanical properties of selective laser melted Ti6Al4V lattice structures , 2015 .

[17]  Zbigniew Lechniak,et al.  Design and manufacture of anatomical hip joint endoprostheses using CAD/CAM systems , 2000 .

[18]  Xiaoyong Tian,et al.  Development Trends in Additive Manufacturing and 3D Printing , 2015 .

[19]  A. Esnaola,et al.  Study of mechanical properties of AISI 316 stainless steel processed by “selective laser melting”, following different manufacturing strategies , 2010 .

[20]  S. Pugalendhi.  Experimental Investigation of Surface Roughness for Fused Deposition Modelled Part with Different Angular Orientation , 2012 .

[21]  P. Layrolle,et al.  Surface treatments of titanium dental implants for rapid osseointegration. , 2007, Dental materials : official publication of the Academy of Dental Materials.

[22]  L. Skovgaard,et al.  Anchorage of TiO2-blasted, HA-coated, and machined implants: an experimental study with rabbits. , 1995, Journal of biomedical materials research.

[23]  Ż. A. Mierzejewska.  Process Optimization Variables for Direct Metal Laser Sintering , 2015 .

[24]  Ann Wennerberg,et al.  Oral implant surfaces: Part 1--review focusing on topographic and chemical properties of different surfaces and in vivo responses to them. , 2004, The International journal of prosthodontics.

[25]  Iain Todd,et al.  Dimensional accuracy of Electron Beam Melting (EBM) additive manufacture with regard to weight optimized truss structures , 2016 .

[26]  I. Gibson,et al.  Material properties and fabrication parameters in selective laser sintering process , 1997 .

[27]  Joshua Lubell,et al.  Additive Manufacturing Technical Workshop Summary Report , 2013 .

[28]  Ian Campbell,et al.  Additive manufacturing: rapid prototyping comes of age , 2012 .

[29]  P. Ducheyne,et al.  Effect of a change in interfacial geometry on the fatigue strength of porous-coated Ti-6A1-4V. , 1994, Journal of biomedical materials research.

[30]  Robert Liska,et al.  Processing of 45S5 Bioglass® by lithography-based additive manufacturing , 2012 .

[31]  Binil Starly,et al.  Bio-CAD modeling and its applications in computer-aided tissue engineering , 2005, Comput. Aided Des..

[32]  E. Toyserkani,et al.  Mechanical properties of additive-manufactured porous titanium bio-structures with oriented macro-scale channels , 2015, The International Journal of Advanced Manufacturing Technology.

[33]  Mamidala Ramulu,et al.  Electron Beam Additive Manufacturing of Titanium Components: Properties and Performance , 2013 .

[34]  I. Yadroitsev,et al.  Strategy of manufacturing components with designed internal structure by selective laser melting of metallic powder , 2007 .

[35]  R. Everson,et al.  Surface roughness analysis, modelling and prediction in selective laser melting , 2013 .

[36]  Giovanna Iezzi,et al.  Influence of implant surfaces on osseointegration. , 2010, Brazilian dental journal.

[37]  M. Janal,et al.  Surface characterization and in vivo evaluation of laser sintered and machined implants followed by resorbable-blasting media process: A study in sheep , 2016, Medicina oral, patologia oral y cirugia bucal.

[38]  V G Smelov,et al.  Selective laser melting of titanium alloy: investigation of mechanical properties and microstructure , 2016 .

[39]  Jack G. Zhou,et al.  PARAMETRIC PROCESS OPTIMIZATION TO IMPROVE THE ACCURACY OF RAPID PROTOTYPED STEREOLITHOGRAPHY PARTS , 2000 .

[40]  Noor Azuan Abu Osman,et al.  Effect of Layer Thickness and Printing Orientation on Mechanical Properties and Dimensional Accuracy of 3D Printed Porous Samples for Bone Tissue Engineering , 2014, PloS one.

[41]  Konda Gokuldoss Prashanth,et al.  Microstructure and mechanical properties of Al-12Si produced by selective laser melting: Effect of heat treatment , 2014 .

[42]  A. A. Zadpoor,et al.  Mechanical properties of open-cell metallic biomaterials manufactured using additive manufacturing , 2013 .

[43]  P. Coelho,et al.  Characterization and in vivo evaluation of laser sintered dental endosseous implants in dogs. , 2012, Journal of biomedical materials research. Part B, Applied biomaterials.

[44]  A. Nanci,et al.  Initial evaluation of bone ingrowth into a novel porous titanium coating. , 2010, Journal of biomedical materials research. Part B, Applied biomaterials.

[45]  A Schmitt,et al.  The longitudinal clinical effectiveness of osseointegrated dental implants: the Toronto study. Part III: Problems and complications encountered. , 1990, The Journal of prosthetic dentistry.

[46]  William E. Frazier,et al.  Metal Additive Manufacturing: A Review , 2014, Journal of Materials Engineering and Performance.

[47]  T. Mower,et al.  Mechanical behavior of additive manufactured, powder-bed laser-fused materials , 2016 .

[48]  T. Brown,et al.  Patient-Specific Bone Implants using Subtractive Rapid Prototyping , 2010 .

[49]  L. D. de Vasconcellos,et al.  HISTOMORPHOMETRIC ANALYSIS OF PURE TITANIUM IMPLANTS WITH POROUS SURFACE VERSUS ROUGH SURFACE , 2006, Journal of applied oral science : revista FOB.

[50]  Aleksandar Matic,et al.  3D printed Ti6Al4V implant surface promotes bone maturation and retains a higher density of less aged osteocytes at the bone-implant interface. , 2016, Acta biomaterialia.

[52]  Giovanna Iezzi,et al.  Bone-to-implant contact around immediately loaded direct laser metal-forming transitional implants in human posterior maxilla. , 2013, Journal of periodontology.

[53]  A. K. Sood,et al.  Improving dimensional accuracy of Fused Deposition Modelling processed part using grey Taguchi method , 2009 .

[54]  Lyndon F Cooper,et al.  Advancing dental implant surface technology--from micron- to nanotopography. , 2008, Biomaterials.

[55]  W. Soboyejo,et al.  Advanced structural materials : properties, design optimization, and applications , 2006 .

[56]  Stefan Stübinger,et al.  Histological and biomechanical analysis of porous additive manufactured implants made by direct metal laser sintering: a pilot study in sheep. , 2013, Journal of biomedical materials research. Part B, Applied biomaterials.

[57]  Pulak M. Pandey,et al.  Statistical modelling and optimization of surface roughness in the selective laser sintering process , 2007 .

[58]  C. Chua,et al.  Cartilage Tissue Engineering with Silk Fibroin Scaffolds Fabricated by Indirect Additive Manufacturing Technology , 2014, Materials.

[59]  Jianfeng Sun,et al.  Development of porous medical implant scaffolds via laser additive manufacturing , 2012 .

[60]  Nikhilesh Chawla,et al.  Microstructure and mechanical behavior of porous sintered steels , 2005 .

[61]  A. Bandyopadhyay,et al.  Influence of porosity on mechanical properties and in vivo response of Ti6Al4V implants. , 2010, Acta biomaterialia.

[62]  T Albrektsson,et al.  Experimental study of turned and grit-blasted screw-shaped implants with special emphasis on effects of blasting material and surface topography. , 1996, Biomaterials.

[63]  Aleksandar Matic,et al.  Long-term osseointegration of 3D printed CoCr constructs with an interconnected open-pore architecture prepared by electron beam melting. , 2016, Acta biomaterialia.

[64]  S. Raman,et al.  A design for the additive manufacture of functionally graded porous structures with tailored mechanical properties for biomedical applications , 2011 .

[65]  G. Manogharan,et al.  Microstructure and Corrosion Resistance of Laser Additively Manufactured 316L Stainless Steel , 2016, JOM.

[66]  Oana Ghita,et al.  Using Raman spectroscopy to monitor surface finish and roughness of components manufactured by selective laser sintering , 2011 .

[67]  Christoph Leyens,et al.  Mechanical properties of additive manufactured titanium (Ti–6Al–4V) blocks deposited by a solid-state laser and wire , 2011 .

[68]  C. MathikumarManikandan,et al.  Experimental Investigation of Surface Roughness for Fused Deposition Modeled Part with Different Angular Orientation , 2012 .

[69]  C. Hardaker,et al.  Surface roughness of ceramic femoral heads after in vivo transfer of metal: correlation to polyethylene wear. , 2005, The Journal of bone and joint surgery. American volume.

[70]  G. A. Longhitano,et al.  Surface Finishes for Ti-6Al-4V Alloy Produced by Direct Metal Laser Sintering , 2015 .

[72]  Kent M. Ogden,et al.  Factors Affecting Dimensional Accuracy of 3-D Printed Anatomical Structures Derived from CT Data , 2015, Journal of Digital Imaging.

[73]  Y. Carvalho,et al.  Porous Titanium by Powder Metallurgy for Biomedical Application: Characterization, Cell Citotoxity and in vivo Tests of Osseointegration , 2012 .