Evidence for an immunological factor in the hypertensive vascular disease.

Hypertensive vascular disease was studied in acute experimental angiotensin induced hypertension. If the hypertension was induced in rats pretreated with injection of thoracic duct lymphocytes the quantity of the mononuclear inflammatory cellular reaction in the damaged arterioles was 2–9 times higher and more prolonged than in control rats. This difference in the cellular reaction is in agreement with the cellular reaction in cases of hypersensitivity of the delayed type.

[1]  F. Olsen.  Lysosomes and pyroninophilia in mononuclear cells in hypertensive arterioles. Studies on the blood, arterioles and regional lymph nodes in experimental angiotensin-hypertension in rats. , 2009, Acta pathologica et microbiologica Scandinavica. Section A, Pathology.

[2]  F. Olsen.  The secondary and tertiary inflammatory cellular reaction in arterioles damaged by acute angiotensin-hypertension in rats. , 2009, Acta pathologica et microbiologica Scandinavica. Section A, Pathology.

[3]  M. Drossman,et al.  Attempted prevention of arteriolar lesions in accelerated rat hypertension by immunosuppression. , 1970, British journal of experimental pathology.

[4]  A. Ebringer,et al.  Raised Serum IgG Levels in Hypertension , 1970, British medical journal.

[5]  F. Olsen.  Penetration of circulating fluorescent proteins into walls of arterioles and venules in rats with intermittent acute angiotensin-hypertension. , 2009, Acta pathologica et microbiologica Scandinavica.

[6]  A. Grollman,et al.  EXPERIMENTAL PERIARTERITIS NODOSA IN THE RAT. , 1964, Archives of pathology.

[7]  B. Waksman,et al.  RADIOAUTOGRAPHIC STUDY OF CELLULAR MECHANISMS IN DELAYED HYPERSENSITIVITY: II. Experimental Allergic Encephalomyelitis in the Rat , 1963, Journal of neuropathology and experimental neurology.

[8]  B. Waksman,et al.  Radioautographic study of cellular mechanisms in delayed hypersensitivity. I. Delayed reactions to tuberculin and purified proteins in the rat and guinea-pig. , 1963, Immunology.