Studies of sarcolemmal integrity in myopathic muscle

Studies of sarcolemmal integrity with extracellular Procion Yellow gave evidence of structural defects in a high percentage of muscle fibers in Duchenne dystrophy and in vitamin E-deficiency myopathy in the guinea pig. The dye entered fibers in these conditions more often than in controls. Myofibrillary clumping occurred in the region of major penetration of the dye. It seems likely that sarcolernmal defects occur in vivo in these conditions, allowing the entry of high concentrations of calcium into the sarcoplasm with consequent fiber damage. The biochemical basis of these sarcolemmal defects remains to be elucidated. Our procedure for biopsy of the vastus medialis muscle may prove useful in preparing a limb muscle for in vitro physiologic studies.

[1]  K. Wrogemann,et al.  MITOCHONDRIAL CALCIUM OVERLOAD: A GENERAL MECHANISM FOR CELL-NECROSIS IN MUSCLE DISEASES , 1976, The Lancet.

[2]  S. Dimauro,et al.  Urinary excretion of carnitine in Duchenne muscular dystrophy. , 1976, Archives of neurology.

[3]  Y. Toyokura,et al.  Alteration of Troponin Subunits in Progressive Muscular Dystrophy (DMP). I:Pattern of Troponin Subunits in DMP , 1976 .

[4]  J. Howell,et al.  α‐TOCOPHEROL RESPONSIVE MUSCULAR DYSTROPHY IN GUINEA PIGS , 1975 .

[5]  W. Schlaepfer.  Calcium-induced degeneration of axoplasm in isolated segments of rat peripheral nerve. , 1974, Brain research.

[6]  H. Schmalbruch.  Contracture knots in normal and diseased muscle fibres. , 1973, Brain : a journal of neurology.

[7]  F. Samaha.  Actomyosin alterations in Duchenne muscular dystrophy. , 1973, Archives of neurology.

[8]  L. Rowland,et al.  Sarcoplasmic reticulum in Duchenne muscular dystrophy. , 1973, Archives of neurology.

[9]  C. Stead.  The Chemistry of Reactive Dyes and its Relevance to Intracellular Staining Techniques , 1973 .

[10]  I. Molenaar,et al.  MITOCHONDRIAL and MICROSOMAL MEMBRANES FROM LIVERS OF VITAMIN E‐DEFICIENT DUCKLINGS , 1972, Annals of the New York Academy of Sciences.

[11]  B. P. Hughes.  Lipid changes in Duchenne muscular dystrophy , 1972, Journal of neurology, neurosurgery, and psychiatry.

[12]  W. Bradley,et al.  Structural changes in the early stages of Duchenne muscular dystrophy , 1972, Journal of neurology, neurosurgery, and psychiatry.

[13]  F. Samaha.  Tropomyosin and troponin in normal and dystrophic human muscle. , 1972, Archives of neurology.

[14]  T. Furukawa,et al.  Muscular Dystrophy and Other Myopathies: Troponin Activity of Natural Actomyosin From Skeletal Muscle , 1972 .

[15]  B. Carlson.  Regeneration of the rat gastrocnemius muscle from sibling and non-sibling muscle fragments. , 1970, The American journal of anatomy.

[16]  M. Worsfold,et al.  Muscular dystrophy and other myopathies: sarcotubular vesicles in early disease , 1969 .

[17]  J. Gergely,et al.  Biochemical abnormalities of the sarcoplasmic reticulum in muscular dystrophy. , 1969, The New England journal of medicine.

[18]  J. V. Van Vleet,et al.  Vitamin E deficiency. A sequential light and electron microscopic study of skeletal muscle degeneration in weanling rabbits. , 1968, The American journal of pathology.

[19]  S. P. Kent.  Diffusion of plasma proteins into cells: a manifestation of cell injury in human myocardial ischemia. , 1967, The American journal of pathology.

[20]  K. Zierler.  Potassium flux and further observations on aldolase flux in dystrophic mouse muscle. , 1961 .

[21]  K. Zierler.  Aldolase leak from muscle of mice with hereditary muscular dystrophy. , 1958, Bulletin of the Johns Hopkins Hospital.

[22]  F. Hommes,et al.  EFFECT OF VITAMIN E ON MEMBRANES OF THE INTESTINAL CELL , 2022 .