ADME-enabling technologies in drug design and development

ADME-Enabling Technologies in Drug Design and Development focuses on the current state of the art in the field, presenting a comprehensive review of the latest tools for generating ADME data in drug discovery. It examines the broadest possible range of available technologies, giving readers the information they need to choose the right tool for a given application, a key requisite for obtaining favorable results in a timely fashion for regulatory filings. With over thirty contributed chapters by an international team of experts, the book provides:

[1]  I. Kola,et al.  Can the pharmaceutical industry reduce attrition rates? , 2004, Nature Reviews Drug Discovery.

[2]  Ragu Ramanathan,et al.  Mass spectrometry in drug metabolism and pharmacokinetics , 2008 .

[3]  P. Murphy,et al.  The Development of Drug Metabolism Research as Expressed in the Publications of ASPET: Part 2, 1959–1983 , 2008, Drug Metabolism and Disposition.

[4]  P. Murphy,et al.  The Development of Drug Metabolism Research as Expressed in the Publications of ASPET: Part 3, 1984–2008 , 2008, Drug Metabolism and Disposition.

[5]  H W ELLIOTT,et al.  The distribution of radioactivity in rats after administration of C14-labeled methadone. , 1949, The Journal of pharmacology and experimental therapeutics.

[6]  M H Bickel,et al.  History of drug metabolism: the first half of the 20th century. , 1985, Drug metabolism reviews.

[7]  H. Morris,et al.  The distribution of radioactivity following the feeding of carbon 14-labeled 2-acetylaminofluorene to rats. , 1950, Cancer research.

[8]  Patrick J Murphy,et al.  The Development of Drug Metabolism Research as Expressed in the Publications of ASPET: Part 1, 1909–1958 , 2008, Drug Metabolism and Disposition.

[9]  A. Conti,et al.  History of Drug Metabolism: Discoveries of the Major Pathways in the 19th Century , 1977 .

[10]  Manouchehr Saljoughian,et al.  Synthetic Tritium Labeling: Reagents and Methodologies , 2002 .

[11]  J. R. Heys,et al.  Preparation of Compounds Labeled with Tritium and Carbon-14 , 2009 .

[12]  M. Kamen,et al.  Long-Lived Radioactive Carbon: C 14 , 1982 .

[13]  P. Murphy,et al.  Xenobiotic metabolism: a look from the past to the future. , 2001, Drug metabolism and disposition: the biological fate of chemicals.

[14]  R. Estabrook,et al.  A passion for P450s (rememberances of the early history of research on cytochrome P450). , 2003, Drug metabolism and disposition: the biological fate of chemicals.

[15]  Bradley L Ackermann,et al.  Current applications of liquid chromatography/mass spectrometry in pharmaceutical discovery after a decade of innovation. , 2008, Annual review of analytical chemistry.