Harnessing plant metabolic diversity.

[1]  K. Rice Synthetic opium alkaloids and derivatives. A short total synthesis of (.+-.)-dihydrothebainone, (.+-.)-dihydrocodeinone, and (.+-.)-nordihydrocodeinone as an approach to a practical synthesis of morphine, codeine, and congeners , 1980 .

[2]  E. Myers,et al.  Basic local alignment search tool. , 1990, Journal of molecular biology.

[3]  M. Schalk,et al.  Redirection of cytosolic or plastidic isoprenoid precursors elevates terpene production in plants , 2006, Nature Biotechnology.

[4]  Bruce Ganem,et al.  Paclitaxel from primary taxanes: a perspective on creative invention in organozirconium chemistry. , 2007, The Journal of organic chemistry.

[5]  Carola Engler,et al.  A One Pot, One Step, Precision Cloning Method with High Throughput Capability , 2008, PloS one.

[6]  D. Nelson The Cytochrome P450 Homepage , 2009, Human Genomics.

[7]  B. Halkier,et al.  Glucosinolate engineering identifies a gamma-glutamyl peptidase. , 2009, Nature chemical biology.

[8]  Brandi L. Cantarel,et al.  The Carbohydrate-Active EnZymes database (CAZy): an expert resource for Glycogenomics , 2008, Nucleic Acids Res..

[9]  Keith E. J. Tyo,et al.  Isoprenoid Pathway Optimization for Taxol Precursor Overproduction in Escherichia coli , 2010, Science.

[10]  R. Kwok Five hard truths for synthetic biology , 2010, Nature.

[11]  C. Buell,et al.  A Stereoselective Hydroxylation Step of Alkaloid Biosynthesis by a Unique Cytochrome P450 in Catharanthus roseus* , 2011, The Journal of Biological Chemistry.

[12]  Sean R. Eddy,et al.  Accelerated Profile HMM Searches , 2011, PLoS Comput. Biol..

[13]  Kai Blin,et al.  antiSMASH: rapid identification, annotation and analysis of secondary metabolite biosynthesis gene clusters in bacterial and fungal genome sequences , 2011, Nucleic Acids Res..

[14]  Vincent Courdavault,et al.  An alternative route to cyclic terpenes by reductive cyclization in iridoid biosynthesis , 2012, Nature.

[15]  Chunyin Zhu,et al.  A concise synthesis of (+)-artemisinin. , 2012, Journal of the American Chemical Society.

[16]  Evan Bolton,et al.  PubChem's BioAssay Database , 2011, Nucleic Acids Res..

[17]  Xue Chen,et al.  Transcriptome analysis based on next-generation sequencing of non-model plants producing specialized metabolites of biotechnological interest. , 2013, Journal of biotechnology.

[18]  A. Osbourn,et al.  Biochemical analysis of a multifunctional cytochrome P450 (CYP51) enzyme required for synthesis of antimicrobial triterpenes in plants , 2013, Proceedings of the National Academy of Sciences.

[19]  J. Forment,et al.  GoldenBraid 2.0: A Comprehensive DNA Assembly Framework for Plant Synthetic Biology1[C][W][OA] , 2013, Plant Physiology.

[20]  J. Keasling,et al.  High-level semi-synthetic production of the potent antimalarial artemisinin , 2013, Nature.

[21]  G. Church,et al.  Large-scale de novo DNA synthesis: technologies and applications , 2014, Nature Methods.

[22]  Anne Osbourn,et al.  Investigation of terpene diversification across multiple sequenced plant genomes , 2014, Proceedings of the National Academy of Sciences.

[23]  Nicola J. Patron,et al.  A golden gate modular cloning toolbox for plants. , 2014, ACS synthetic biology.

[24]  C. Smolke,et al.  A microbial biomanufacturing platform for natural and semi-synthetic opiates , 2014, Nature chemical biology.

[25]  H. Bouwmeester,et al.  The seco-iridoid pathway from Catharanthus roseus , 2014, Nature Communications.

[26]  Tadao Sugiura,et al.  KNApSAcK Metabolite Activity Database for retrieving the relationships between metabolites and biological activities. , 2014, Plant & cell physiology.

[27]  Xiao Sun,et al.  Data access for the 1,000 Plants (1KP) project , 2014, GigaScience.

[28]  Yang Qu,et al.  Completion of the seven-step pathway from tabersonine to the anticancer drug precursor vindoline and its assembly in yeast , 2015, Proceedings of the National Academy of Sciences.

[29]  Yunqi Weng,et al.  Plants as Factories for Human Pharmaceuticals: Applications and Challenges , 2015, International journal of molecular sciences.

[30]  Warren Lau,et al.  Six enzymes from mayapple that complete the biosynthetic pathway to the etoposide aglycone , 2015, Science.

[31]  Christian Rogers,et al.  Standards for plant synthetic biology: a common syntax for exchange of DNA parts. , 2015, The New phytologist.

[32]  C. Smolke,et al.  Complete biosynthesis of opioids in yeast , 2015, Science.

[33]  J. Noel,et al.  Orthologs of the archaeal isopentenyl phosphate kinase regulate terpenoid production in plants , 2015, Proceedings of the National Academy of Sciences.

[34]  Zachary N. Russ,et al.  An enzyme-coupled biosensor enables (S)-reticuline production in yeast from glucose. , 2015, Nature chemical biology.

[35]  T. Ellis,et al.  Bricks and blueprints: methods and standards for DNA assembly , 2015, Nature Reviews Molecular Cell Biology.

[36]  Rainer Fischer,et al.  The increasing value of plant-made proteins. , 2015, Current opinion in biotechnology.

[37]  Nicole K Clay,et al.  A new cyanogenic metabolite in Arabidopsis required for inducible pathogen defense , 2015, Nature.

[38]  Carla S. Jones,et al.  Minimum Information about a Biosynthetic Gene cluster. , 2015, Nature chemical biology.

[39]  T. Muranaka,et al.  Identification and genome organization of saponin pathway genes from a wild crucifer, and their use for transient production of saponins in Nicotiana benthamiana. , 2015, The Plant journal : for cell and molecular biology.

[40]  S. O’Connor,et al.  De novo production of the plant-derived alkaloid strictosidine in yeast , 2015, Proceedings of the National Academy of Sciences.

[41]  Rainer Fischer,et al.  Patterns of CRISPR/Cas9 activity in plants, animals and microbes , 2016, Plant biotechnology journal.

[42]  J. Keasling,et al.  Engineering Cellular Metabolism , 2016, Cell.

[43]  Gang Fu,et al.  PubChem Substance and Compound databases , 2015, Nucleic Acids Res..

[44]  Yanran Li,et al.  Engineering biosynthesis of the anticancer alkaloid noscapine in yeast , 2016, Nature Communications.

[45]  H. Bouwmeester,et al.  Transient production of artemisinin in Nicotiana benthamiana is boosted by a specific lipid transfer protein from A. annua. , 2016, Metabolic engineering.

[46]  Anne Osbourn,et al.  Plant metabolic clusters - from genetics to genomics. , 2016, The New phytologist.

[47]  M. Reichelt,et al.  Optimization of Engineered Production of the Glucoraphanin Precursor Dihomomethionine in Nicotiana benthamiana , 2016, Front. Bioeng. Biotechnol..

[48]  Tilmann Weber,et al.  The evolution of genome mining in microbes - a review. , 2016, Natural product reports.

[49]  A. Aharoni,et al.  Elucidation of the first committed step in betalain biosynthesis enables the heterologous engineering of betalain pigments in plants. , 2016, The New phytologist.

[50]  Yo Suzuki,et al.  Synthetic Biology Standards and Methods of DNA Assembly , 2016 .

[51]  Jürgen Pleiss,et al.  BioCatNet: A Database System for the Integration of Enzyme Sequences and Biocatalytic Experiments , 2016, Chembiochem : a European journal of chemical biology.

[52]  Paul S. Freemont,et al.  Delineation of metabolic gene clusters in plant genomes by chromatin signatures , 2016, Nucleic acids research.

[53]  G. Lomonossoff,et al.  Molecular pharming - VLPs made in plants. , 2016, Current opinion in biotechnology.

[54]  Paulina Kanigowska,et al.  Smart DNA Fabrication Using Sound Waves , 2016, Journal of laboratory automation.

[55]  Kai Blin,et al.  plantiSMASH: automated identification, annotation and expression analysis of plant biosynthetic gene clusters , 2016, bioRxiv.

[56]  E. Sattely,et al.  Biosynthesis of cabbage phytoalexins from indole glucosinolate , 2017, Proceedings of the National Academy of Sciences.

[57]  A. Aharoni,et al.  The PhytoClust tool for metabolic gene clusters discovery in plant genomes , 2016, bioRxiv.