University of Birmingham Factors associated with maternal death from direct pregnancy complications

Objective To investigate the factors associated with maternal death from direct pregnancy complications in the UK. Design Unmatched case – control analysis. Results Six factors were associated with maternal of antenatal (adjusted ratio, CI 3.14 – 7.40); previous pregnancy problems (aOR 2.21, 95% CI 1.34 – 3.62); hypertensive disorders of pregnancy (aOR 2.44, 95% CI 1.31 – 4.52); and Indian ethnicity (aOR 2.70, 95% CI 1.14 – 6.43). Of the increased risk associated with maternal death, 70% (95% CI 66 – 73%) could be attributed to these factors. Odds associated with maternal death increased by three and a half times per unit increase in the ‘risk factor’ score (aOR 3.59, 95% CI 2.83 – 4.56). Conclusions This study shows that medical comorbidities are importantly associated with direct (obstetric) deaths. Further studies are required to understand whether specific aspects of care could be improved to reduce maternal deaths among women with medical comorbidities in the UK.

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