Drp1 levels constitutively regulate mitochondrial dynamics and cell survival in cortical neurons

[1]  Xiongwei Zhu,et al.  Amyloid-β overproduction causes abnormal mitochondrial dynamics via differential modulation of mitochondrial fission/fusion proteins , 2008, Proceedings of the National Academy of Sciences.

[2]  Hansong Deng,et al.  The Parkinson's disease genes pink1 and parkin promote mitochondrial fission and/or inhibit fusion in Drosophila , 2008, Proceedings of the National Academy of Sciences.

[3]  Mark H Ellisman,et al.  Opa1-mediated cristae opening is Bax/Bak and BH3 dependent, required for apoptosis, and independent of Bak oligomerization. , 2008, Molecular cell.

[4]  Xiongwei Zhu,et al.  Dynamin-like protein 1 reduction underlies mitochondrial morphology and distribution abnormalities in fibroblasts from sporadic Alzheimer's disease patients. , 2008, The American journal of pathology.

[5]  S. Frank,et al.  Shaping mitochondria: The complex posttranslational regulation of the mitochondrial fission protein DRP1 , 2008, IUBMB life.

[6]  E. Müller,et al.  Characterization of OPA1 isoforms isolated from mouse tissues , 2008, Journal of neurochemistry.

[7]  G. Perkins,et al.  Mitochondrial fragmentation in neurodegeneration , 2008, Nature Reviews Neuroscience.

[8]  S. Dimauro,et al.  Mitochondrial disorders in the nervous system. , 2008, Annual review of neuroscience.

[9]  M. Beal,et al.  Pink1 regulates mitochondrial dynamics through interaction with the fission/fusion machinery , 2008, Proceedings of the National Academy of Sciences.

[10]  P. Greengard,et al.  WAVE1 controls neuronal activity-induced mitochondrial distribution in dendritic spines , 2008, Proceedings of the National Academy of Sciences.

[11]  Richard J. Flannery,et al.  Bcl-xL induces Drp1-dependent synapse formation in cultured hippocampal neurons , 2008, Proceedings of the National Academy of Sciences.

[12]  T. Kuwana,et al.  Chemical inhibition of the mitochondrial division dynamin reveals its role in Bax/Bak-dependent mitochondrial outer membrane permeabilization. , 2008, Developmental cell.

[13]  Angela C. Poole,et al.  The PINK1/Parkin pathway regulates mitochondrial morphology , 2008, Proceedings of the National Academy of Sciences.

[14]  T. Uo,et al.  Apoptotic Actions of p53 Require Transcriptional Activation of PUMA and Do Not Involve a Direct Mitochondrial/Cytoplasmic Site of Action in Postnatal Cortical Neurons , 2007, The Journal of Neuroscience.

[15]  D. Sellers,et al.  Adult spinal cord progenitor cells are repelled by netrin-1 in the embryonic and injured adult spinal cord , 2007, Proceedings of the National Academy of Sciences.

[16]  D. Chan,et al.  OPA1 processing controls mitochondrial fusion and is regulated by mRNA splicing, membrane potential, and Yme1L , 2007, The Journal of cell biology.

[17]  David S. Park,et al.  Mitofusin 2 Protects Cerebellar Granule Neurons against Injury-induced Cell Death* , 2007, Journal of Biological Chemistry.

[18]  H. McBride,et al.  Bax/Bak promote sumoylation of DRP1 and its stable association with mitochondria during apoptotic cell death , 2007, The Journal of cell biology.

[19]  H. Waterham,et al.  A lethal defect of mitochondrial and peroxisomal fission. , 2007, The New England journal of medicine.

[20]  G A Perkins,et al.  Mitochondrial fission is an upstream and required event for bax foci formation in response to nitric oxide in cortical neurons , 2007, Cell Death and Differentiation.

[21]  M. Beal,et al.  Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases , 2006, Nature.

[22]  Jean-Claude Martinou,et al.  Nitric oxide‐induced mitochondrial fission is regulated by dynamin‐related GTPases in neurons , 2006, The EMBO journal.

[23]  D. Chan,et al.  Emerging functions of mammalian mitochondrial fusion and fission. , 2005, Human molecular genetics.

[24]  Axel Niemann,et al.  Ganglioside-induced differentiation associated protein 1 is a regulator of the mitochondrial network , 2005, The Journal of cell biology.

[25]  R. Youle,et al.  Mitochondrial fission in apoptosis , 2005, Nature Reviews Molecular Cell Biology.

[26]  D. Chan,et al.  Disruption of Fusion Results in Mitochondrial Heterogeneity and Dysfunction* , 2005, Journal of Biological Chemistry.

[27]  T. Uo,et al.  Neurons Exclusively Express N-Bak, a BH3 Domain-only Bak Isoform That Promotes Neuronal Apoptosis* , 2005, Journal of Biological Chemistry.

[28]  Yasunori Hayashi,et al.  The Importance of Dendritic Mitochondria in the Morphogenesis and Plasticity of Spines and Synapses , 2004, Cell.

[29]  L. Scorrano,et al.  OPA1 requires mitofusin 1 to promote mitochondrial fusion. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[30]  P. Chan Mitochondria and Neuronal Death/Survival Signaling Pathways in Cerebral Ischemia , 2004, Neurochemical Research.

[31]  R. Youle,et al.  Roles of the mammalian mitochondrial fission and fusion mediators Fis1, Drp1, and Opa1 in apoptosis. , 2004, Molecular biology of the cell.

[32]  M. Pericak-Vance,et al.  Mutations in the mitochondrial GTPase mitofusin 2 cause Charcot-Marie-Tooth neuropathy type 2A , 2004, Nature Genetics.

[33]  A. M. van der Bliek,et al.  Loss of the Intermembrane Space Protein Mgm1/OPA1 Induces Swelling and Localized Constrictions along the Lengths of Mitochondria* , 2004, Journal of Biological Chemistry.

[34]  S. Howng,et al.  Genomic organization, alternative splicing, and promoter analysis of human dynamin-like protein gene. , 2004, Biochemical and biophysical research communications.

[35]  J. Martinou,et al.  hFis1, a Novel Component of the Mammalian Mitochondrial Fission Machinery* , 2003, Journal of Biological Chemistry.

[36]  M. McNiven,et al.  The Mitochondrial Protein hFis1 Regulates Mitochondrial Fission in Mammalian Cells through an Interaction with the Dynamin-Like Protein DLP1 , 2003, Molecular and Cellular Biology.

[37]  G. Lenaers,et al.  Loss of OPA1 Perturbates the Mitochondrial Inner Membrane Structure and Integrity, Leading to Cytochrome c Release and Apoptosis* , 2003, The Journal of Biological Chemistry.

[38]  A. Scherer,et al.  Crystal structure of a dynamin GTPase domain in both nucleotide‐free and GDP‐bound forms , 2001, The EMBO journal.

[39]  A. M. van der Bliek,et al.  Dynamin-related protein Drp1 is required for mitochondrial division in mammalian cells. , 2001, Molecular biology of the cell.

[40]  J. Grosgeorge,et al.  Nuclear gene OPA1, encoding a mitochondrial dynamin-related protein, is mutated in dominant optic atrophy , 2000, Nature Genetics.

[41]  S. Bhattacharya,et al.  OPA1, encoding a dynamin-related GTPase, is mutated in autosomal dominant optic atrophy linked to chromosome 3q28 , 2000, Nature Genetics.

[42]  Mark D. Johnson,et al.  Contribution of p53-Dependent Caspase Activation to Neuronal Cell Death Declines with Neuronal Maturation , 1999, The Journal of Neuroscience.

[43]  A. M. van der Bliek,et al.  A Human Dynamin-related Protein Controls the Distribution of Mitochondria , 1998, The Journal of cell biology.

[44]  M. McNiven,et al.  A Novel Dynamin-like Protein Associates with Cytoplasmic Vesicles and Tubules of the Endoplasmic Reticulum in Mammalian Cells , 1998, The Journal of cell biology.

[45]  P. Schwartzkroin,et al.  Evidence for p53-Mediated Modulation of Neuronal Viability , 1996, The Journal of Neuroscience.