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Cancer: When catastrophe strikes a cell

In 2–3% of cancers, a single genetic event may have led to hundreds of genomic rearrangements confined to just one or a few chromosomes. This finding challenges the conventional view of how mutations accumulate in oncogenesis.

Xavier Estivill | Jose M. C. Tubio | X. Estivill | J. Tubío

[1] I. Belyaev,et al. DNA fragmentation and morphological changes in apoptotic human lymphocytes. , 2002, Biochemical and biophysical research communications.

[2] L. Testolin,et al. Mapping the initial DNA breaks in apoptotic Jurkat cells using ligation-mediated PCR , 2003, Cell Death and Differentiation.

[3] N. Carter,et al. Massive Genomic Rearrangement Acquired in a Single Catastrophic Event during Cancer Development , 2011, Cell.

[4] M. Stanulla,et al. Mechanisms of MLL gene rearrangement: site-specific DNA cleavage within the breakpoint cluster region is independent of chromosomal context. , 2001, Human molecular genetics.

[5] K. Golic,et al. Telomere Loss Provokes Multiple Pathways to Apoptosis and Produces Genomic Instability in Drosophila melanogaster , 2008, Genetics.

[6] T. Cremer,et al. Chromosome territories, nuclear architecture and gene regulation in mammalian cells , 2001, Nature Reviews Genetics.

[7] M. Stratton,et al. The cancer genome , 2009, Nature.

[8] D. Richard. Instabilités hydrodynamiques dans les écoulements en rotation différentielle , 2001 .

[9] P. Deloukas,et al. Signatures of mutation and selection in the cancer genome , 2010, Nature.

[10] P. Carroll,et al. INHIBITION OF APOPTOSIS BY THE γ-HERPESVIRUSES , 2003 .

[11] Derek Y. Chiang,et al. The landscape of somatic copy-number alteration across human cancers , 2010, Nature.