A REVIEW ON SELF MICRO EMULSIFYING DRUG DELIVERY SYSTEM: AN APPROACH TO E NHANCE THE ORAL BIOAVAILABILITY OF POORLY WATER SOLUBLE DRUGS

Technology Catalysts International reported in 2002 that approximately 35 - 40% of all new chemical compounds suffer from poor aqu eous solubility and present a major challenge to modern drug delivery system, because of their low oral bioavailability . Several strategies to improve the solubility and dissolution of poorly water soluble drugs have been developed, which were at start pri marily based on modifying the drug’s physicochemical properties. Realization that the oral bioavailability of poor water soluble drugs may be enhanced when co - administered with meal rich in fat has led to increasing recent interest in the formulation of po orly water soluble drugs in lipids. Lipid - based drug delivery systems have gained considerable interest after the commercial success of Sandimmune Neoral TM (Cyclosporine A), Novartis Pvt. Ltd. and Fortovase (Saquinavir), Roche Laboratories Inc. Self micro - emulsifyin g drug delivery systems are a class of lipid based drug delivery systems. Self micro emulsifying drug delivery systems are isotropic mixtures of oil, surfactant, and co surfactant and are a vital tool in solving low bioavailability issues of poor ly soluble drugs. L ipophilic drugs can be dissolved in these systems, enabling them to be administered as a unit dosage form for per - oral administration. When such a system is released in the lumen of the gastrointestinal tract, it disperses to f orm a fine w/o microemulsion with the aid of GI fluid. This leads to in situ solubilization of drug that can subsequently be absorbed by lymphatic pathway s, bypassing the hepatic first - pass effect. This article represents a complete review on self micro - emulsifying drug delivery system.

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