NEUROTICISM MEDIATES THE EFFECT OF P2RX7 ON OUTCOMES OF MOOD DISORDERS

We previously reported an association between P2RX7 variant rs208294, diagnosis, and the longitudinal course of mood disorders. Here, we test whether the personality trait neuroticism mediates the effect of P2RX7 on the course of mood disorders.

[1]  P. Barberger‐Gateau,et al.  Chronic Low-Grade Inflammation in Elderly Persons Is Associated with Altered Tryptophan and Tyrosine Metabolism: Role in Neuropsychiatric Symptoms , 2011, Biological Psychiatry.

[2]  T. Paunio,et al.  P2RX7 gene is associated consistently with mood disorders and predicts clinical outcome in three clinical cohorts , 2011, American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics.

[3]  S. Paunonen,et al.  Personality vulnerabilities to psychopathology: relations between trait structure and affective-cognitive processes. , 2011, Journal of personality.

[4]  K. Kendler,et al.  A longitudinal etiologic model for symptoms of anxiety and depression in women , 2011, Psychological Medicine.

[5]  R. Kotov,et al.  Personality and depression: explanatory models and review of the evidence. , 2011, Annual review of clinical psychology.

[6]  A. Beekman,et al.  Psychological characteristics of chronic depression: a longitudinal cohort study. , 2011, The Journal of clinical psychiatry.

[7]  Ian B Hickie,et al.  Neuropsychological Clustering Highlights Cognitive Differences In Young People Presenting With Depressive Symptoms , 2011, Journal of the International Neuropsychological Society.

[8]  N. Freimer,et al.  Genome-Wide Linkage Scan of Bipolar Disorder in a Colombian Population Isolate Replicates Loci on Chromosomes 7p21–22, 1p31, 16p12 and 21q21–22 and Identifies a Novel Locus on Chromosome 12q , 2010, Human Heredity.

[9]  Y. Forsell,et al.  Variations in FKBP5 and BDNF genes are suggestively associated with depression in a Swedish population-based cohort. , 2010, Journal of affective disorders.

[10]  K. Kendler,et al.  Genome-wide linkage scans for major depression in individuals with alcohol dependence. , 2010, Journal of psychiatric research.

[11]  T. Piser.  Linking the cytokine and neurocircuitry hypotheses of depression: A translational framework for discovery and development of novel anti-depressants , 2010, Brain, Behavior, and Immunity.

[12]  E. Isometsä,et al.  A prospective latent analyses study of psychiatric comorbidity of DSM-IV bipolar I and II disorders. , 2010, Bipolar disorders.

[13]  Chung S. Yang,et al.  Ca2+‐dependent reduction of glutamate aspartate transporter GLAST expression in astrocytes by P2X7 receptor‐mediated phosphoinositide 3‐kinase signaling , 2010, Journal of neurochemistry.

[14]  T. Paunio,et al.  A population‐based association study of candidate genes for depression and sleep disturbance , 2010, American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics.

[15]  T. Schulze.  Genetic research into bipolar disorder: the need for a research framework that integrates sophisticated molecular biology and clinically informed phenotype characterization. , 2010, The Psychiatric clinics of North America.

[16]  S. Hamilton,et al.  The genetics of major depression: moving beyond the monoamine hypothesis. , 2010, The Psychiatric clinics of North America.

[17]  S. Skaper,et al.  The P2X7 purinergic receptor: from physiology to neurological disorders , 2010, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[18]  E. Isometsä,et al.  Maintenance treatment received by patients with bipolar I and II disorders--a naturalistic prospective study. , 2010, Journal of affective disorders.

[19]  M. Jarvis.  The neural–glial purinergic receptor ensemble in chronic pain states , 2010, Trends in Neurosciences.

[20]  L. Ferrucci,et al.  High Neuroticism and low Conscientiousness are associated with interleukin-6 , 2009, Psychological Medicine.

[21]  G. Kirov,et al.  P2RX7: A bipolar and unipolar disorder candidate susceptibility gene? , 2009, American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics.

[22]  Thomas W. Mühleisen,et al.  Variation in P2RX7 candidate gene (rs2230912) is not associated with bipolar I disorder and unipolar major depression in four European samples , 2009, American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics.

[23]  S. Skaper,et al.  P2X7 Receptors as a Transducer in the Co-Occurrence of Neurological/Psychiatric and Cardiovascular Disorders: A Hypothesis , 2009, Cardiovascular psychiatry and neurology.

[24]  A. McQuillin,et al.  Case–control studies show that a non-conservative amino-acid change from a glutamine to arginine in the P2RX7 purinergic receptor protein is associated with both bipolar- and unipolar-affective disorders , 2009, Molecular Psychiatry.

[25]  H. Rytsälä,et al.  Neuroticism, introversion, and major depressive disorder—traits, states, or scars? , 2009, Depression and anxiety.

[26]  A. Székely,et al.  Association between depression and the Gln460Arg polymorphism of P2RX7 Gene: A dimensional approach , 2009, American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics.

[27]  E. Isometsä,et al.  Course and outcome of depressive disorders in primary care: a prospective 18-month study , 2009, Psychological Medicine.

[28]  C. Harmer,et al.  Risk for depression and neural responses to fearful facial expressions of emotion. , 2009, The British journal of psychiatry : the journal of mental science.

[29]  Z. Rónai,et al.  P2RX7 Gln460Arg polymorphism is associated with depression among diabetic patients , 2008, Progress in Neuro-Psychopharmacology and Biological Psychiatry.

[30]  R. Bagby,et al.  Neuroticism as a mediator of treatment response to SSRIs in major depressive disorder. , 2008, Journal of affective disorders.

[31]  N. Wray,et al.  Association study of candidate variants from brain-derived neurotrophic factor and dystrobrevin-binding protein 1 with neuroticism, anxiety, and depression , 2008, Psychiatric genetics.

[32]  C. Matute.  P2X7 Receptors in Oligodendrocytes: A Novel Target for Neuroprotection , 2008, Molecular Neurobiology.

[33]  E. Isometsä,et al.  Maintenance pharmacotherapy for recurrent major depressive disorder: 5-year follow-up study , 2008, British Journal of Psychiatry.

[34]  Z. Segal,et al.  Personality and Differential Treatment Response in Major Depression: A Randomized Controlled Trial Comparing Cognitive-Behavioural Therapy and Pharmacotherapy , 2008, Canadian journal of psychiatry. Revue canadienne de psychiatrie.

[35]  E. Isometsä,et al.  Differences in outcome of DSM-IV bipolar I and II disorders. , 2008, Bipolar disorders.

[36]  A. Serretti,et al.  The genetics of bipolar disorder: genome ‘hot regions,’ genes, new potential candidates and future directions , 2008, Molecular Psychiatry.

[37]  H. Rytsälä,et al.  Long-term outcome of major depressive disorder in psychiatric patients is variable. , 2008, The Journal of clinical psychiatry.

[38]  F. Holsboer,et al.  Association of polymorphisms in P2RX7 and CaMKKb with anxiety disorders. , 2007, Journal of affective disorders.

[39]  M. Bennett.  Synaptic P2X7 Receptor Regenerative-Loop Hypothesis for Depression , 2007, The Australian and New Zealand journal of psychiatry.

[40]  K. Kendler,et al.  A genome‐wide linkage analysis for the personality trait neuroticism in the Irish affected sib‐pair study of alcohol dependence , 2007, American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics.

[41]  D. Boomsma,et al.  Family Based Association Analyses between the Serotonin Transporter Gene Polymorphism (5-HTTLPR) and Neuroticism, Anxiety and Depression , 2007, Behavior genetics.

[42]  S. Hodge,et al.  A Third-Pass Genome Scan in Panic Disorder: Evidence for Multiple Susceptibility Loci , 2006, Biological Psychiatry.

[43]  F. Holsboer,et al.  P2RX7, a gene coding for a purinergic ligand-gated ion channel, is associated with major depressive disorder. , 2006, Human molecular genetics.

[44]  D. Russell,et al.  Advances in testing the statistical significance of mediation effects. , 2006 .

[45]  E. Shink,et al.  Analysis of single nucleotide polymorphisms in genes in the chromosome 12Q24.31 region points to P2RX7 as a susceptibility gene to bipolar affective disorder , 2006, American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics.

[46]  K. Kendler,et al.  A population-based twin study of the relationship between neuroticism and internalizing disorders. , 2006, The American journal of psychiatry.

[47]  P. R. Boyd,et al.  Whole genome linkage scan of recurrent depressive disorder from the depression network study. , 2005, Human molecular genetics.

[48]  F. Di Virgilio,et al.  A His-155 to Tyr Polymorphism Confers Gain-of-Function to the Human P2X7 Receptor of Human Leukemic Lymphocytes1 , 2005, The Journal of Immunology.

[49]  Jacqueline K. Wittke-Thompson,et al.  Rational inferences about departures from Hardy-Weinberg equilibrium. , 2005, American journal of human genetics.

[50]  E. Isometsä,et al.  Depressive disorders in primary care: recurrent, chronic, and co-morbid , 2004, Psychological Medicine.

[51]  E. Isometsä,et al.  The clinical characteristics of DSM-IV bipolar I and II disorders: baseline findings from the Jorvi Bipolar Study (JoBS). , 2004, Bipolar disorders.

[52]  T. Suppes,et al.  Correlates of 1-year prospective outcome in bipolar disorder: results from the Stanley Foundation Bipolar Network. , 2004, The American journal of psychiatry.

[53]  H. Rytsälä,et al.  Severity and comorbidity predict episode duration and recurrence of DSM-IV major depressive disorder. , 2004, The Journal of clinical psychiatry.

[54]  Janice M. Fullerton,et al.  Linkage analysis of extremely discordant and concordant sibling pairs identifies quantitative-trait loci that influence variation in the human personality trait neuroticism. , 2003, American journal of human genetics.

[55]  H. Rytsälä,et al.  Current comorbidity of psychiatric disorders among DSM-IV major depressive disorder patients in psychiatric care in the Vantaa Depression Study. , 2002, The Journal of clinical psychiatry.

[56]  M. Taylor,et al.  The Genetics of Mood Disorders. , 1991, The American journal of psychiatry.

[57]  R. C. Young,et al.  A Rating Scale for Mania: Reliability, Validity and Sensitivity , 1978, British Journal of Psychiatry.

[58]  A. Beck,et al.  An inventory for measuring depression. , 1961, Archives of general psychiatry.

[59]  M. Hamilton.  A RATING SCALE FOR DEPRESSION , 1960, Journal of neurology, neurosurgery, and psychiatry.

[60]  H. Eysenck,et al.  Manual of the Eysenck personality questionnaire , 1975 .