Detection of K-ras mutations in lung carcinomas: relationship to prognosis.

[1]  J. L. Bos,et al.  ras oncogenes in human cancer: a review. , 1989, Cancer research.

[2]  S. Belinsky,et al.  Relationship between the formation of promutagenic adducts and the activation of the K-ras protooncogene in lung tumors from A/J mice treated with nitrosamines. , 1989, Cancer research.

[3]  K. Mullis,et al.  Specific synthesis of DNA in vitro via a polymerase-catalyzed chain reaction. , 1987, Methods in enzymology.

[4]  D. Shibata,et al.  Most human carcinomas of the exocrine pancreas contain mutant c-K-ras genes , 1988, Cell.

[5]  S. Rodenhuis,et al.  Clinical significance of ras oncogene activation in human lung cancer. , 1992, Cancer research.

[6]  W. Thilly,et al.  Molecular analysis of complex human cell populations: mutational spectra of MNNG and ICR-191. , 1990, Mutation research.

[7]  F. McCormick,et al.  A cytoplasmic protein stimulates normal N-ras p21 GTPase, but does not affect oncogenic mutants. , 1987, Science.

[8]  P. Seeburg,et al.  Biological properties of human c-Ha-ras1 genes mutated at codon 12 , 1984, Nature.

[9]  D. Lowy,et al.  Guanosine triphosphatase activating protein (GAP) interacts with the p21 ras effector binding domain. , 1988, Science.

[10]  S. Steinberg,et al.  ras gene mutations in non-small cell lung cancers are associated with shortened survival irrespective of treatment intent. , 1991, Cancer research.

[11]  R. Katakura,et al.  Detection of p53 gene mutations in human brain tumors by single-strand conformation polymorphism analysis of polymerase chain reaction products. , 1991, Oncogene.

[12]  W. Thilly,et al.  Mutational spectrometry: a general approach for hot-spot point mutations in selectable genes. , 1992, Proceedings of the National Academy of Sciences of the United States of America.

[13]  C. Marshall,et al.  The cytoplasmic protein GAP is implicated as the target for regulation by the ras gene product , 1988, Nature.

[14]  D. Spandidos.  Oncogene activation in malignant transformation: a study of H-ras in human breast cancer. , 1987, Anticancer research.

[15]  L. Lerman,et al.  DNA fragments differing by single base-pair substitutions are separated in denaturing gradient gels: correspondence with melting theory. , 1983, Proceedings of the National Academy of Sciences of the United States of America.

[16]  Frank McCormick,et al.  ras GTPase activating protein: Signal transmitter and signal terminator , 1989, Cell.

[17]  K. Sugimachi,et al.  ras gene mutations as a prognostic marker in adenocarcinoma of the human lung without lymph node metastasis. , 1992, Cancer research.

[18]  B. Glickman,et al.  Sequence specificity of mutations induced by benzo[a]pyrene-7,8-diol-9,10-epoxide at endogenousaprt gene in CHO cells , 1988, Somatic cell and molecular genetics.

[19]  W. Thilly,et al.  Fidelity of DNA polymerases in DNA amplification. , 1989, Proceedings of the National Academy of Sciences of the United States of America.

[20]  V. Sheffield,et al.  Attachment of a 40-base-pair G + C-rich sequence (GC-clamp) to genomic DNA fragments by the polymerase chain reaction results in improved detection of single-base changes. , 1989, Proceedings of the National Academy of Sciences of the United States of America.

[21]  C. Der,et al.  Biological and biochemical properties of human ras H genes mutated at codon 61 , 1986, Cell.

[22]  S. Hirohashi,et al.  Association of point mutation in c‐Ki‐ras oncogene in lung adenocarcinoma with particular reference to cytologic subtypes , 1990, Cancer.

[23]  M. Ridanpää,et al.  K‐ras mutations in human adenocarcinoma of the lung: Association with smoking and occupational exposure to asbestos , 1993, International journal of cancer.

[24]  Visvanathan Kv,et al.  Preferential and novel activation of H-ras in human bladder carcinomas. , 1988 .

[25]  J. Mccormick,et al.  Effect of excision repair by diploid human fibroblasts on the kinds and locations of mutations induced by (+/-)-7 beta,8 alpha-dihydroxy-9 alpha,10 alpha-epoxy-7,8,9,10- tetrahydrobenzo[a]pyrene in the coding region of the HPRT gene. , 1990, Proceedings of the National Academy of Sciences of the United States of America.

[26]  G. Fleuren,et al.  KRAS codon 12 mutations occur very frequently in pancreatic adenocarcinomas. , 1988, Nucleic acids research.

[27]  B. Vogelstein,et al.  Prevalence of ras gene mutations in human colorectal cancers , 1987, Nature.

[28]  T. Sekiya,et al.  Detection of ras gene mutations in human lung cancers by single-strand conformation polymorphism analysis of polymerase chain reaction products. , 1990, Oncogene.

[29]  Irving S. Sigal,et al.  Cloning of bovine GAP and its interaction with oncogenic ras p21 , 1988, Nature.

[30]  J. Even,et al.  Two adjacent mutations at position 12 activate the K-ras2 oncogene of a human mammary tumor cell line. , 1987, Oncogene research.

[31]  S. Rodenhuis,et al.  Incidence and possible clinical significance of K-ras oncogene activation in adenocarcinoma of the human lung. , 1988, Cancer research.

[32]  K. Mullis,et al.  Primer-directed enzymatic amplification of DNA with a thermostable DNA polymerase. , 1988, Science.

[33]  J. Bos,et al.  The ras gene family and human carcinogenesis. , 1988, Mutation research.

[34]  William E. Grizzle,et al.  Detection of high incidence of K-ras oncogenes during human colon tumorigenesis , 1987, Nature.

[35]  J. Minna,et al.  Mutations of ras genes distinguish a subset of non-small-cell lung cancer cell lines from small-cell lung cancer cell lines. , 1991, Oncogene.

[36]  S. Rodenhuis,et al.  Relationship between K-ras oncogene activation and smoking in adenocarcinoma of the human lung. , 1991, Journal of the National Cancer Institute.

[37]  I. Summerhayes,et al.  Preferential and novel activation of H-ras in human bladder carcinomas. , 1988, Oncogene research.