Biomimetic hydrogels for controlled biomolecule delivery to augment bone regeneration.

[1]  M. Lutolf,et al.  Artificial niche microarrays for probing single stem cell fate in high throughput , 2011, Nature Methods.

[2]  Adrian Ranga,et al.  Engineering 3D cell instructive microenvironments by rational assembly of artificial extracellular matrices and cell patterning. , 2011, Integrative biology : quantitative biosciences from nano to macro.

[3]  Matthias P Lutolf,et al.  Biomaterials meet microfluidics: building the next generation of artificial niches. , 2011, Current opinion in biotechnology.

[4]  Ralph Müller,et al.  Engineering the Growth Factor Microenvironment with Fibronectin Domains to Promote Wound and Bone Tissue Healing , 2011, Science Translational Medicine.

[5]  Daniel J. Gould,et al.  Biomimetic hydrogels with immobilized ephrinA1 for therapeutic angiogenesis. , 2011, Biomacromolecules.

[6]  J. Hilborn,et al.  Bone reservoir: Injectable hyaluronic acid hydrogel for minimal invasive bone augmentation. , 2011, Journal of controlled release : official journal of the Controlled Release Society.

[7]  Bradley K Weiner,et al.  A critical review of recombinant human bone morphogenetic protein-2 trials in spinal surgery: emerging safety concerns and lessons learned. , 2011, The spine journal : official journal of the North American Spine Society.

[8]  J. Turnbull,et al.  Extracellular matrix and cell signalling: the dynamic cooperation of integrin, proteoglycan and growth factor receptor. , 2011, The Journal of endocrinology.

[9]  D. Mooney,et al.  Growth factor delivery-based tissue engineering: general approaches and a review of recent developments , 2011, Journal of The Royal Society Interface.

[10]  Xu Feng,et al.  Disorders of bone remodeling. , 2011, Annual review of pathology.

[11]  Mikaël M. Martino,et al.  The 12th-14th type III repeats of fibronectin function as a highly promiscuous growth factor-binding domain. , 2010, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[12]  Jennifer Patterson,et al.  Hyaluronic acid hydrogels with controlled degradation properties for oriented bone regeneration. , 2010, Biomaterials.

[13]  C. Colnot,et al.  Immunolocalization of BMPs, BMP antagonists, receptors, and effectors during fracture repair. , 2010, Bone.

[14]  P. Giannoudis,et al.  BMPs: Options, Indications, and Effectiveness , 2010, Journal of orthopaedic trauma.

[15]  S. Sakiyama-Elbert,et al.  Controlled Release of Neurotrophin-3 and Platelet-Derived Growth Factor from Fibrin Scaffolds Containing Neural Progenitor Cells Enhances Survival and Differentiation into Neurons in a Subacute Model of SCI , 2010, Cell transplantation.

[16]  S. Sakiyama-Elbert,et al.  Controlled release of neurotrophin‐3 from fibrin‐based tissue engineering scaffolds enhances neural fiber sprouting following subacute spinal cord injury , 2009, Biotechnology and bioengineering.

[17]  R. Hynes.  The Extracellular Matrix: Not Just Pretty Fibrils , 2009, Science.

[18]  Neha S. Gandhi,et al.  Free energy calculations of glycosaminoglycan-protein interactions. , 2009, Glycobiology.

[19]  Carsten Werner,et al.  A star-PEG-heparin hydrogel platform to aid cell replacement therapies for neurodegenerative diseases. , 2009, Biomaterials.

[20]  Matthias P Lutolf,et al.  Artificial Stem Cell Niches , 2009, Advanced materials.

[21]  Robert E Guldberg,et al.  Spatiotemporal Delivery Strategies for Promoting Musculoskeletal Tissue Regeneration , 2009, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[22]  Tessa Lühmann,et al.  The induction of cell alignment by covalently immobilized gradients of the 6th Ig-like domain of cell adhesion molecule L1 in 3D-fibrin matrices. , 2009, Biomaterials.

[23]  M. Radisic,et al.  Biomimetic approach to tissue engineering. , 2009, Seminars in cell & developmental biology.

[24]  G. Steffens,et al.  Tissue Substitutes with Improved Angiogenic Capabilities: An in vitro Investigation with Endothelial Cells and Endothelial Progenitor Cells , 2009, Cells Tissues Organs.

[25]  Kristi S Anseth,et al.  Controlling Affinity Binding with Peptide‐Functionalized Poly(ethylene glycol) Hydrogels , 2009, Advanced functional materials.

[26]  Nic D. Leipzig,et al.  Functional immobilization of interferon-gamma induces neuronal differentiation of neural stem cells. , 2009, Journal of biomedical materials research. Part A.

[27]  Zhifeng Xiao,et al.  Collagen-binding human epidermal growth factor promotes cellularization of collagen scaffolds. , 2009, Tissue engineering. Part A.

[28]  J. Feijen,et al.  In vivo recruitment of hematopoietic cells using stromal cell-derived factor 1 alpha-loaded heparinized three-dimensional collagen scaffolds. , 2009, Tissue engineering. Part A.

[29]  Lorenz Meinel,et al.  Biopolymer-based growth factor delivery for tissue repair: from natural concepts to engineered systems. , 2009, Tissue engineering. Part B, Reviews.

[30]  E. Place,et al.  Complexity in biomaterials for tissue engineering. , 2009, Nature materials.

[31]  H. Dietz,et al.  Extracellular Microfibrils in Vertebrate Development and Disease Processes* , 2009, Journal of Biological Chemistry.

[32]  Zhifeng Xiao,et al.  Linear ordered collagen scaffolds loaded with collagen-binding brain-derived neurotrophic factor improve the recovery of spinal cord injury in rats. , 2009, Tissue engineering. Part A.

[33]  Bin Wang,et al.  Human basic fibroblast growth factor fused with Kringle4 peptide binds to a fibrin scaffold and enhances angiogenesis. , 2009, Tissue engineering. Part A.

[34]  Kristi S. Anseth,et al.  Photodegradable Hydrogels for Dynamic Tuning of Physical and Chemical Properties , 2009, Science.

[35]  C. Streuli,et al.  Signal co-operation between integrins and other receptor systems. , 2009, The Biochemical journal.

[36]  J. Hubbell,et al.  Bone healing induced by local delivery of an engineered parathyroid hormone prodrug. , 2009, Biomaterials.

[37]  Daniel Scherman,et al.  Growth factor delivery approaches in hydrogels. , 2009, Biomacromolecules.

[38]  R. Gelberman,et al.  Controlled-release kinetics and biologic activity of platelet-derived growth factor-BB for use in flexor tendon repair. , 2008, The Journal of hand surgery.

[39]  D. Stupack,et al.  Regulation of angiogenesis: apoptotic cues from the ECM , 2008, Oncogene.

[40]  E. Jabbari,et al.  Effect of grafting RGD and BMP-2 protein-derived peptides to a hydrogel substrate on osteogenic differentiation of marrow stromal cells. , 2008, Langmuir : the ACS journal of surfaces and colloids.

[41]  D. Hu,et al.  Effect of age on vascularization during fracture repair , 2008, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

[42]  Aaron Schindeler,et al.  Bone remodeling during fracture repair: The cellular picture. , 2008, Seminars in cell & developmental biology.

[43]  G. Prestwich,et al.  Recruitment of endogenous stem cells for tissue repair. , 2008, Macromolecular bioscience.

[44]  A. Allori,et al.  Biological basis of bone formation, remodeling, and repair-part II: extracellular matrix. , 2008, Tissue engineering. Part B, Reviews.

[45]  D. Wukich,et al.  The management of ankle fractures in patients with diabetes. , 2008, The Journal of bone and joint surgery. American volume.

[46]  Bing Chen,et al.  Improved neovascularization and wound repair by targeting human basic fibroblast growth factor (bFGF) to fibrin , 2008, Journal of Molecular Medicine.

[47]  G. Prestwich,et al.  Microvascular maturity elicited in tissue treated with cytokine-loaded hyaluronan-based hydrogels. , 2008, Biomaterials.

[48]  Milica Radisic,et al.  Vascular endothelial growth factor immobilized in collagen scaffold promotes penetration and proliferation of endothelial cells. , 2008, Acta biomaterialia.

[49]  J. Hubbell,et al.  The role of actively released fibrin-conjugated VEGF for VEGF receptor 2 gene activation and the enhancement of angiogenesis. , 2008, Biomaterials.

[50]  Melinda Larsen,et al.  Extracellular matrix dynamics in development and regenerative medicine , 2008, Journal of Cell Science.

[51]  J. Lynch,et al.  Femoral Nonunion: Risk Factors and Treatment Options , 2008, The Journal of the American Academy of Orthopaedic Surgeons.

[52]  S. Kakar,et al.  Stimulation of fracture-healing with systemic intermittent parathyroid hormone treatment. , 2008, The Journal of bone and joint surgery. American volume.

[53]  David Silverstein,et al.  Growth factor binding to the pericellular matrix and its importance in tissue engineering. , 2007, Advanced drug delivery reviews.

[54]  Aaron D Baldwin,et al.  Production of heparin-functionalized hydrogels for the development of responsive and controlled growth factor delivery systems. , 2007, Journal of controlled release : official journal of the Controlled Release Society.

[55]  Matthias P Lutolf,et al.  Enzymatic formation of modular cell-instructive fibrin analogs for tissue engineering. , 2007, Biomaterials.

[56]  Matthias P Lutolf,et al.  Biomolecular hydrogels formed and degraded via site-specific enzymatic reactions. , 2007, Biomacromolecules.

[57]  Laura J Suggs,et al.  Controlled release of stromal cell-derived factor-1 alpha in situ increases c-kit+ cell homing to the infarcted heart. , 2007, Tissue engineering.

[58]  R. Zellweger,et al.  BONE MORPHOGENETIC PROTEINS IN CLINICAL APPLICATIONS , 2007, ANZ journal of surgery.

[59]  Thomas A. Einhorn,et al.  Current and future clinical applications of bone morphogenetic proteins in orthopaedic trauma surgery , 2007, International Orthopaedics.

[60]  H. Dietz,et al.  Extracellular microfibrils in development and disease , 2007, Cellular and Molecular Life Sciences.

[61]  Matthew J. Silva,et al.  PDGF‐BB released in tendon repair using a novel delivery system promotes cell proliferation and collagen remodeling , 2007, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

[62]  I. Bahar,et al.  Tenascin cytotactin epidermal growth factor‐like repeat binds epidermal growth factor receptor with low affinity , 2007, Journal of cellular physiology.

[63]  Jeffrey D. Esko,et al.  Heparan sulphate proteoglycans fine-tune mammalian physiology , 2007, Nature.

[64]  Mark J Post,et al.  Therapeutic angiogenesis in the heart: protect and serve. , 2007, Current opinion in pharmacology.

[65]  A. Schindeler,et al.  The anabolic and catabolic responses in bone repair. , 2007, The Journal of bone and joint surgery. British volume.

[66]  E. Furst,et al.  Growth factor mediated assembly of cell receptor-responsive hydrogels. , 2007, Journal of the American Chemical Society.

[67]  Glenn D Prestwich,et al.  Release of basic fibroblast growth factor from a crosslinked glycosaminoglycan hydrogel promotes wound healing , 2007, Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society.

[68]  Zhifeng Xiao,et al.  Collagen membranes loaded with collagen-binding human PDGF-BB accelerate wound healing in a rabbit dermal ischemic ulcer model , 2007, Growth factors.

[69]  G. Prestwich,et al.  Stimulation of in vivo angiogenesis using dual growth factor-loaded crosslinked glycosaminoglycan hydrogels. , 2006, Biomaterials.

[70]  Frank A. Liporace,et al.  Diabetic fracture healing. , 2006, Foot and ankle clinics.

[71]  S. Sakiyama-Elbert,et al.  Effect of controlled delivery of neurotrophin-3 from fibrin on spinal cord injury in a long term model. , 2006, Journal of controlled release : official journal of the Controlled Release Society.

[72]  Thomas A. Einhorn,et al.  Fracture healing in the elderly patient , 2006, Experimental Gerontology.

[73]  Robert J Fisher,et al.  Heparin-regulated release of growth factors in vitro and angiogenic response in vivo to implanted hyaluronan hydrogels containing VEGF and bFGF. , 2006, Biomaterials.

[74]  Kristi L Kiick,et al.  Manipulation of hydrogel assembly and growth factor delivery via the use of peptide-polysaccharide interactions. , 2006, Journal of controlled release : official journal of the Controlled Release Society.

[75]  S. Koch,et al.  Enhancing angiogenesis in collagen matrices by covalent incorporation of VEGF , 2006, Journal of materials science. Materials in medicine.

[76]  E. Rosenzweig,et al.  Delivery of neurotrophin-3 from fibrin enhances neuronal fiber sprouting after spinal cord injury. , 2006, Journal of controlled release : official journal of the Controlled Release Society.

[77]  A. Hoffman,et al.  PEG-cross-linked heparin is an affinity hydrogel for sustained release of vascular endothelial growth factor , 2006, Journal of biomaterials science. Polymer edition.

[78]  Valerie Liu Tsang,et al.  Photo- and electropatterning of hydrogel-encapsulated living cell arrays. , 2005, Lab on a chip.

[79]  S. Andreadis,et al.  Biomimetic delivery of keratinocyte growth factor upon cellular demand for accelerated wound healing in vitro and in vivo. , 2005, The American journal of pathology.

[80]  N Pallua,et al.  Effects of Modified Collagen Matrices on Human Umbilical Vein Endothelial Cells , 2005, The International journal of artificial organs.

[81]  M. Mohammadi,et al.  A protein canyon in the FGF-FGF receptor dimer selects from an à la carte menu of heparan sulfate motifs. , 2005, Current opinion in structural biology.

[82]  Glenn D Prestwich,et al.  Injectable glycosaminoglycan hydrogels for controlled release of human basic fibroblast growth factor. , 2005, Biomaterials.

[83]  J. Elisseeff,et al.  Advances in skeletal tissue engineering with hydrogels. , 2005, Orthodontics & craniofacial research.

[84]  N. Perrimon,et al.  Developmental cell biology: Heparan sulphate proteoglycans: the sweet side of development , 2005, Nature Reviews Molecular Cell Biology.

[85]  K. Anseth,et al.  Heparin functionalized PEG gels that modulate protein adsorption for hMSC adhesion and differentiation. , 2005, Acta biomaterialia.

[86]  M. Fussenegger,et al.  Effects of Protein and Gene Transfer of the Angiopoietin-1 Fibrinogen-like Receptor-binding Domain on Endothelial and Vessel Organization* , 2005, Journal of Biological Chemistry.

[87]  Jennifer L West,et al.  Covalently immobilized gradients of bFGF on hydrogel scaffolds for directed cell migration. , 2005, Biomaterials.

[88]  K. Kiick,et al.  Polysaccharide-poly(ethylene glycol) star copolymer as a scaffold for the production of bioactive hydrogels. , 2005, Biomacromolecules.

[89]  J. Hubbell,et al.  Neurite extension and in vitro myelination within three-dimensional modified fibrin matrices. , 2005, Journal of neurobiology.

[90]  E. Mackenzie,et al.  Impact of Smoking on Fracture Healing and Risk of Complications in Limb-Threatening Open Tibia Fractures , 2005, Journal of orthopaedic trauma.

[91]  Franz E Weber,et al.  Bone repair with a form of BMP-2 engineered for incorporation into fibrin cell ingrowth matrices. , 2005, Biotechnology and bioengineering.

[92]  Martin Ehrbar,et al.  Endothelial cell proliferation and progenitor maturation by fibrin-bound VEGF variants with differential susceptibilities to local cellular activity. , 2005, Journal of controlled release : official journal of the Controlled Release Society.

[93]  N Pallua,et al.  Modulation of angiogenic potential of collagen matrices by covalent incorporation of heparin and loading with vascular endothelial growth factor. , 2004, Tissue engineering.

[94]  J. Hubbell,et al.  Matrix-bound sixth Ig-like domain of cell adhesion molecule L1 acts as an angiogenic factor by ligating αvβ3-integrin and activating VEGF-R2 , 2004 .

[95]  Sangeeta N Bhatia,et al.  Three-dimensional tissue fabrication. , 2004, Advanced drug delivery reviews.

[96]  Lorenz Meinel,et al.  Localized delivery of growth factors for bone repair. , 2004, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

[97]  J. Mcdonald,et al.  Controlled release of neurotrophin-3 from fibrin gels for spinal cord injury. , 2004, Journal of controlled release : official journal of the Controlled Release Society.

[98]  J. Hubbell,et al.  Engineered fibrin matrices for functional display of cell membrane-bound growth factor-like activities: study of angiogenic signaling by ephrin-B2. , 2004, Biomaterials.

[99]  P. Thompson,et al.  αvβ3 Integrin Interacts with the Transforming Growth Factor β (TGFβ) Type II Receptor to Potentiate the Proliferative Effects of TGFβ1 in Living Human Lung Fibroblasts* , 2004, Journal of Biological Chemistry.

[100]  Jeffrey A. Hubbell,et al.  Cell-Demanded Liberation of VEGF121 From Fibrin Implants Induces Local and Controlled Blood Vessel Growth , 2004, Circulation research.

[101]  Ralph Müller,et al.  Synthetic extracellular matrices for in situ tissue engineering , 2004, Biotechnology and bioengineering.

[102]  D Seliktar,et al.  MMP-2 sensitive, VEGF-bearing bioactive hydrogels for promotion of vascular healing. , 2004, Journal of biomedical materials research. Part A.

[103]  Martin Ehrbar,et al.  Cell‐demanded release of VEGF from synthetic, biointeractive cell‐ingrowth matrices for vascularized tissue growth , 2003, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[104]  Guido Tarone,et al.  Positional control of cell fate through joint integrin/receptor protein kinase signaling. , 2003, Annual review of cell and developmental biology.

[105]  W. Friess,et al.  Collagen sponges for bone regeneration with rhBMP-2. , 2003, Advanced drug delivery reviews.

[106]  J. Ware,et al.  Therapeutic angiogenesis in cardiovascular disease , 2003, Nature Reviews Drug Discovery.

[107]  L. Trusolino,et al.  Interactions between growth factor receptors and adhesion molecules: breaking the rules. , 2003, Current opinion in cell biology.

[108]  Jeffrey A Hubbell,et al.  Materials as morphogenetic guides in tissue engineering. , 2003, Current opinion in biotechnology.

[109]  David J. Mooney,et al.  Polymeric Growth Factor Delivery Strategies for Tissue Engineering , 2003, Pharmaceutical Research.

[110]  T. Einhorn.  Clinical applications of recombinant human BMPs: early experience and future development. , 2003, The Journal of bone and joint surgery. American volume.

[111]  Ralph Müller,et al.  Repair of bone defects using synthetic mimetics of collagenous extracellular matrices , 2003, Nature Biotechnology.

[112]  R. Khokha,et al.  Binding to EGF receptor of a laminin-5 EGF-like fragment liberated during MMP-dependent mammary gland involution , 2003, The Journal of cell biology.

[113]  Thomas A Einhorn,et al.  Fracture healing as a post‐natal developmental process: Molecular, spatial, and temporal aspects of its regulation , 2003, Journal of cellular biochemistry.

[114]  Holger Gerhardt,et al.  Spatially restricted patterning cues provided by heparin-binding VEGF-A control blood vessel branching morphogenesis. , 2002, Genes & development.

[115]  Brian H Annex,et al.  A target‐mediated model to describe the pharmacokinetics and hemodynamic effects of recombinant human vascular endothelial growth factor in humans , 2002, Clinical pharmacology and therapeutics.

[116]  Ingeborg Stalmans,et al.  Arteriolar and venular patterning in retinas of mice selectively expressing VEGF isoforms. , 2002, The Journal of clinical investigation.

[117]  Nicholas A Peppas,et al.  Molecular imprinting within hydrogels. , 2002, Advanced drug delivery reviews.

[118]  L. Trusolino,et al.  A Signaling Adapter Function for α6β4 Integrin in the Control of HGF-Dependent Invasive Growth , 2001, Cell.

[119]  A A Poot,et al.  Binding and release of basic fibroblast growth factor from heparinized collagen matrices. , 2001, Biomaterials.

[120]  J. Wozney,et al.  Delivering on the promise of bone morphogenetic proteins. , 2001, Trends in biotechnology.

[121]  J. Feijen,et al.  In vivo biocompatibility of carbodiimide-crosslinked collagen matrices: Effects of crosslink density, heparin immobilization, and bFGF loading. , 2001, Journal of biomedical materials research.

[122]  J. Hubbell,et al.  Covalently conjugated VEGF--fibrin matrices for endothelialization. , 2001, Journal of controlled release : official journal of the Controlled Release Society.

[123]  R. Kalluri,et al.  Identification of the Anti-angiogenic Site within Vascular Basement Membrane-derived Tumstatin* , 2001, The Journal of Biological Chemistry.

[124]  J. Hubbell,et al.  Development of growth factor fusion proteins for cell‐triggered drug delivery , 2001, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[125]  G. Zych,et al.  Osteogenic Protein-1 (Bone Morphogenetic Protein-7) in the Treatment of Tibial Nonunions: A Prospective, Randomized Clinical Trial Comparing rhOP-1 with Fresh Bone Autograft* , 2001, The Journal of bone and joint surgery. American volume.

[126]  F. Veronese.  Peptide and protein PEGylation: a review of problems and solutions. , 2001, Biomaterials.

[127]  Jennifer L. West,et al.  Tethered-TGF-β increases extracellular matrix production of vascular smooth muscle cells , 2001 .

[128]  Zhi-xin Xu,et al.  Rational design of a potent, long-lasting form of interferon: a 40 kDa branched polyethylene glycol-conjugated interferon alpha-2a for the treatment of hepatitis C. , 2001, Bioconjugate chemistry.

[129]  J. Hubbell,et al.  Controlled release of nerve growth factor from a heparin-containing fibrin-based cell ingrowth matrix. , 2000, Journal of controlled release : official journal of the Controlled Release Society.

[130]  R. Johnson,et al.  Isoforms of Vascular Endothelial Growth Factor Act in a Coordinate Fashion To Recruit and Expand Tumor Vasculature , 2000, Molecular and Cellular Biology.

[131]  H. Blau,et al.  VEGF gene delivery to myocardium: deleterious effects of unregulated expression. , 2000, Circulation.

[132]  J. Feijen,et al.  Endothelial cell seeding of (heparinized) collagen matrices: effects of bFGF pre-loading on proliferation (after low density seeding) and pro-coagulant factors. , 2000, Journal of controlled release : official journal of the Controlled Release Society.

[133]  J. Hubbell,et al.  Development of fibrin derivatives for controlled release of heparin-binding growth factors. , 2000, Journal of controlled release : official journal of the Controlled Release Society.

[134]  P. Carmeliet.  Mechanisms of angiogenesis and arteriogenesis , 2000, Nature Medicine.

[135]  R. Kalluri,et al.  Canstatin, a Novel Matrix-derived Inhibitor of Angiogenesis and Tumor Growth* , 2000, The Journal of Biological Chemistry.

[136]  J. Hubbell,et al.  Incorporation of heparin‐binding peptides into fibrin gels enhances neurite extension: an example of designer matrices in tissue engineering , 1999, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[137]  I. Kola,et al.  Cathepsin K Knockout Mice Develop Osteopetrosis Due to a Deficit in Matrix Degradation but Not Demineralization , 1999, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[138]  Willem Flameng,et al.  Impaired myocardial angiogenesis and ischemic cardiomyopathy in mice lacking the vascular endothelial growth factor isoforms VEGF164 and VEGF188 , 1999, Nature Medicine.

[139]  R. Soldi,et al.  Role of αvβ3 integrin in the activation of vascular endothelial growth factor receptor‐2 , 1999, The EMBO journal.

[140]  J. Wozney,et al.  Recombinant human bone morphogenetic protein-2 and collagen for bone regeneration. , 1998, Journal of biomedical materials research.

[141]  L. Silengo,et al.  Integrins induce activation of EGF receptor: role in MAP kinase induction and adhesion‐dependent cell survival , 1998, The EMBO journal.

[142]  T A Einhorn,et al.  The cell and molecular biology of fracture healing. , 1998, Clinical orthopaedics and related research.

[143]  J. Williams,et al.  Postoperative Drains at the Donor Sites of Iliac-Crest Bone Grafts. A Prospective, Randomized Study of Morbidity at the Donor Site in Patients Who Had a Traumatic Injury of the Spine* , 1998, The Journal of bone and joint surgery. American volume.

[144]  H. Bentz,et al.  Improved local delivery of TGF-beta2 by binding to injectable fibrillar collagen via difunctional polyethylene glycol. , 1998, Journal of biomedical materials research.

[145]  M. Crescenzi,et al.  α6β4 and α6β1 Integrins Associate with ErbB-2 in Human Carcinoma Cell Lines , 1997 .

[146]  E. Ruoslahti,et al.  αvβ3 integrin associates with activated insulin and PDGFβ receptors and potentiates the biological activity of PDGF , 1997 .

[147]  William Arbuthnot Sir Lane,et al.  Endostatin: An Endogenous Inhibitor of Angiogenesis and Tumor Growth , 1997, Cell.

[148]  John M. Whitelock,et al.  The Degradation of Human Endothelial Cell-derived Perlecan and Release of Bound Basic Fibroblast Growth Factor by Stromelysin, Collagenase, Plasmin, and Heparanases (*) , 1996, The Journal of Biological Chemistry.

[149]  E. Edelman,et al.  Kinetics of basic fibroblast growth factor binding to its receptor and heparan sulfate proteoglycan: a mechanism for cooperactivity. , 1992, Biochemistry.

[150]  T. McCaffrey,et al.  Transforming growth factor‐β1 is a heparin‐binding protein: Identification of putative heparin‐binding regions and isolation of heparins with varying affinity for TGF‐β1 , 1992 .

[151]  Mark E. Bolander,et al.  Regulation of Fracture Repair by Growth Factors , 1992, Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine.

[152]  J. Wozney,et al.  The bone morphogenetic protein family and osteogenesis , 1992, Molecular reproduction and development.

[153]  J. Delaissé,et al.  Degradation of collagen in the bone‐resorbing compartment underlying the osteoclast involves both cysteine‐proteinases and matrix metalloproteinases , 1992, Journal of cellular physiology.

[154]  J. Engel.  EGF‐like domains in extracellular matrix proteins: Localized signals for growth and differentiation? , 1989, FEBS letters.

[155]  R. Timpl,et al.  Domains of laminin with growth-factor activity , 1989, Cell.

[156]  V. Rosen,et al.  Novel regulators of bone formation: molecular clones and activities. , 1988, Science.

[157]  D. Baylink,et al.  In vitro evidence that bone formation may be coupled to resorption by release of mitogen(s) from resorbing bone. , 1987, Metabolism: clinical and experimental.

[158]  A. Schreiber,et al.  Heparin binds endothelial cell growth factor, the principal endothelial cell mitogen in bovine brain. , 1984, Science.

[159]  M J Bissell,et al.  How does the extracellular matrix direct gene expression? , 1982, Journal of theoretical biology.

[160]  M. Urist.  Bone: Formation by Autoinduction , 1965, Science.

[161]  J. Hubbell,et al.  Engineered insulin-like growth factor-1 for improved smooth muscle regeneration. , 2012, Biomaterials.

[162]  J. Hubbell,et al.  Engineered aprotinin for improved stability of fibrin biomaterials. , 2011, Biomaterials.

[163]  Daniel J. Gould,et al.  Covalently immobilized platelet-derived growth factor-BB promotes angiogenesis in biomimetic poly(ethylene glycol) hydrogels. , 2011, Acta biomaterialia.

[164]  C. Plank,et al.  Future of local bone regeneration - Protein versus gene therapy. , 2011, Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery.

[165]  S. Sakiyama-Elbert,et al.  Fibrin-based tissue engineering scaffolds enhance neural fiber sprouting and delay the accumulation of reactive astrocytes at the lesion in a subacute model of spinal cord injury. , 2010, Journal of biomedical materials research. Part A.

[166]  J. Hubbell,et al.  Heterophilic interactions between cell adhesion molecule L1 and αv β3-integrin induce HUVEC process extension in vitro and angiogenesis in vivo , 2004, Angiogenesis.

[167]  J. West,et al.  Effects of Epidermal Growth Factor on Fibroblast Migration through Biomimetic Hydrogels , 2003, Biotechnology progress.

[168]  J. Hubbell,et al.  Cross-linking exogenous bifunctional peptides into fibrin gels with factor XIIIa. , 1999, Bioconjugate chemistry.

[169]  H. Chambers,et al.  Complications of iliac crest bone graft harvesting. , 1996, Clinical orthopaedics and related research.

[170]  M. Bissell,et al.  Dynamic reciprocity: how do extracellular matrix and hormones direct gene expression? , 1987, Progress in clinical and biological research.