Optical tomography of a realistic neonatal head phantom.

We have begun clinical trials of optical tomography of the neonatal brain. To validate this research, we have built and imaged an anatomically realistic, tissue-equivalent neonatal head phantom that is hollow, allowing contrasting objects to be placed inside it. Images were reconstructed by use of two finite-element meshes, one generated from a computed tomography image of the phantom and the other spherical. The phantom was filled with a liquid of the same optical properties as the outer region, and two perturbations were placed inside. These were successfully imaged with good separation between the absorption and scatter coefficients. The phantom was then refilled with a liquid of increased absorption compared with the background to simulate the brain, and the absolute properties of the two regions were found. These were used as a priori information for the complete reconstruction. Both perturbations were visible, superimposed on the increased absorption of the central region. The head-shaped mesh performed slightly better than the spherical mesh, particularly when the absorption of the central region of the phantom was increased.

[1]  Fabrizio Martelli,et al.  Assessment of an in situ temporal calibration method for time-resolved optical tomography. , 2003, Journal of biomedical optics.

[2]  D T Delpy,et al.  Linear single-step image reconstruction in the presence of nonscattering regions. , 2002, Journal of the Optical Society of America. A, Optics, image science, and vision.

[3]  Time resolved optical imaging of the newborn infant brain: initial clinical results , 2002 .

[4]  V. Ntziachristos,et al.  MRI-guided diffuse optical spectroscopy of malignant and benign breast lesions. , 2002, Neoplasia.

[5]  A. Hielscher,et al.  Three-dimensional optical tomography of hemodynamics in the human head. , 2001, Optics express.

[6]  D. Boas,et al.  Bedside functional imaging of the premature infant brain during passive motor activation , 1999, Photonics West - Biomedical Optics.

[7]  S R Arridge,et al.  Three-dimensional time-resolved optical tomography of a conical breast phantom. , 2001, Applied optics.

[8]  J. Mandeville,et al.  The Accuracy of Near Infrared Spectroscopy and Imaging during Focal Changes in Cerebral Hemodynamics , 2001, NeuroImage.

[9]  S Zhong,et al.  Instrumentation and calibration protocol for imaging dynamic features in dense-scattering media by optical tomography. , 2000, Applied optics.

[10]  Arridge,et al.  Optical tomography in the presence of void regions , 2000, Journal of the Optical Society of America. A, Optics, image science, and vision.

[11]  N Iftimia,et al.  Experimental three-dimensional optical image reconstruction of heterogeneous turbid media from continuous-wave data. , 2000, Optics express.

[12]  M. Schweiger,et al.  Multiple-slice imaging of a tissue-equivalent phantom by use of time-resolved optical tomography. , 2000, Applied optics.

[13]  Atsushi Maki,et al.  Spontaneous oscillation of oxy- and deoxy- hemoglobin changes with a phase difference throughout the occipital cortex of newborn infants observed using non-invasive optical topography , 2000, Neuroscience Letters.

[14]  A. Kleinschmidt,et al.  Noninvasive Functional Imaging of Human Brain Using Light , 2000, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[15]  D. Delpy,et al.  A 32-channel time-resolved instrument for medical optical tomography , 2000 .

[16]  Simon R. Arridge,et al.  A method for three-dimensional time-resolved optical tomography , 2000, Int. J. Imaging Syst. Technol..

[17]  S R Arridge,et al.  Optical tomographic reconstruction in a complex head model using a priori region boundary information. , 1999, Physics in medicine and biology.

[18]  M. Kohl,et al.  Near-infrared optical properties of ex vivo human skin and subcutaneous tissues measured using the Monte Carlo inversion technique. , 1998, Physics in medicine and biology.

[19]  B. Chance,et al.  A novel method for fast imaging of brain function, non-invasively, with light. , 1998, Optics express.

[20]  Joachim Schöberl,et al.  NETGEN An advancing front 2D/3D-mesh generator based on abstract rules , 1997 .

[21]  A Taddeucci,et al.  Optical properties of brain tissue. , 1996, Journal of biomedical optics.

[22]  M. Schweiger,et al.  The finite element method for the propagation of light in scattering media: boundary and source conditions. , 1995, Medical physics.

[23]  D. Delpy,et al.  An improved design for a stable and reproducible phantom material for use in near-infrared spectroscopy and imaging. , 1995, Physics in medicine and biology.

[24]  David T. Delpy,et al.  Optical properties of brain tissue , 1993, Photonics West - Lasers and Applications in Science and Engineering.

[25]  Britton Chance,et al.  Photon Migration and Imaging in Random Media and Tissues , 1993 .