Trichloroethylene exposure. Simulation of uptake, excretion, and metabolism using a mathematical model.

The absorption, distribution, and excretion of trichloroethylene, as well as the kinetics of formation and elimination of trichloroethanol (TCE) and trichloroacetic acid (TCA) were simulated by a mathematical model. The results of this model have been satisfactorily compared with those obtained experimentally from pulmonary elimination of the solvent and from urinary excretion of the metabolites. The model permitted a study of the distribution of the solvent in the different tissues of the organism as well as an evaluation of the body burden of TCE and TCA. The influence of the duration and repetition of the exposure on the urinary eliminations of TCE and TCA was studied, and showed that the excretion of the first metabolite represents the most recent exposure while that of the second is related to the average exposure of the preceding days. The study of the pulmonary elimination of trichloroethylene during single or repeated exposures showed a linear relationship between the alveolar concentration of the solvent approximately 15 hours after the end of the exposure and the quantity of trichloroethylene accumulated in the fatty tissues.

[1]  J. E. Peterson,et al.  Use of breath analysis to monitor trichloroethylene exposures. , 1974, Archives of environmental health.

[2]  E. Gubéran,et al.  Control of industrial exposure to tetrachloroethylene by measuring alveolar concentrations: theoretical approach using a mathematical model , 1974, British journal of industrial medicine.

[3]  D. Breimer,et al.  Gas chromatographic determination of chloral hydrate, trichloroethanol and trichloroacetic acid in blood and in urine employing head-space analysis , 1974 .

[4]  K. Singhal,et al.  Simulation and prediction of uptake, distribution, and exhalation of organic solvents , 1974, British journal of industrial medicine.

[5]  M. Ikeda,et al.  Biological half-life of trichloroethylene and tetrachloroethylene in human subjects , 1973, Internationales Archiv fur Arbeitsmedizin.

[6]  W. Mapleson,et al.  Solubility coefficients for inhaled anaesthetics for water, oil and biological media. , 1973, British journal of anaesthesia.

[7]  H. H. Borgstedt,et al.  Tissue weights and rates of blood flow in man for the prediction of anesthetic uptake and distribution. , 1971, Anesthesiology.

[8]  M. Ogata,et al.  Excretion of organic chlorine compounds in the urine of persons exposed to vapours of trichloroethylene and tetrachloroethylene , 1971, British journal of industrial medicine.

[9]  E. Sellers,et al.  KINETICS AND CLINICAL IMPORTANCE OF DISPLACEMENT OF WARFARIN FROM ALBUMIN BY ACIDIC DRUGS * , 1971, Annals of the New York Academy of Sciences.

[10]  K. Nomiyama,et al.  Metabolism of trichloroethylene in human , 1971, Archiv für Gewerbepathologie und Gewerbehygiene.

[11]  K. Leibman.  Metabolism of trichloroethylene in liver microsomes. I. Characteristics of the reaction. , 1965, Molecular pharmacology.

[12]  K. Leibman,et al.  Metabolism of trichloroethylene in liver microsomes. II. Identification of the reaction product as chloral hydrate. , 1965, Molecular pharmacology.

[13]  V. Bartonícek.  Metabolism and Excretion of Trichloroethylene after Inhalation by Human Subjects , 1962, British journal of industrial medicine.

[14]  B. Soucek,et al.  Excretion of Trichloroethylene Metabolites in Human Urine , 1960, British Journal of Industrial Medicine.

[15]  A. Owens,et al.  A comparison of the metabolism of ethanol and trichloroethanol. , 1955, Bulletin of the Johns Hopkins Hospital.

[16]  A. Owens,et al.  Further studies on the metabolic fate of chloral hydrate and trichloroethanol. , 1955, Bulletin of the Johns Hopkins Hospital.

[17]  A. Owens,et al.  Absorption, excretion and metabolic fate of chloral hydrate and trichloroethanol. , 1954, Bulletin of the Johns Hopkins Hospital.

[18]  S. Kety.  The theory and applications of the exchange of inert gas at the lungs and tissues. , 1951, Pharmacological reviews.

[19]  T. Butler.  METABOLIC TRANSFORMATIONS OF TRICHLOROETHYLENE , 1949 .

[20]  J. Powell,et al.  The excretion of sodium trichloracetate. , 1945, The Journal of pharmacology and experimental therapeutics.

[21]  W W MAPLESON,et al.  An electric analogue for uptake and exchange of inert gases and other agents. , 1963, Journal of applied physiology.

[22]  Grafflin Al,et al.  In vivo studies of the frog's liver during the excretion of thioflavine S and vasoflavine. , 1954 .

[23]  T. Butler.  Metabolic transformations of trichlorethylene. , 1949, The Journal of pharmacology and experimental therapeutics.