CLINICAL TRIALS The use of a battery of pain models to detect analgesic properties of compounds: a two-part four-way crossover study

(+10.1%), phenytoin (+8.5%) and pregabalin (+10.8%). The PTT for mechanical pain was increased by pregabalin (+14.1%). The cold pressor PTT was increased by fentanyl (+17.1%) and pregabalin (+46.4%). Normal skin heat pain detection threshold was increased by (S)-ketamine (+3.3%), fentanyl (+2.8%) and pregabalin (+4.1%). UVB treated skin pain detection threshold was increased by fentanyl (+2.6%) and ibuprofen (+4.0%). No differences in conditioned pain modulation were observed. these pain models are able to detect changes in pain thresholds after administration of different classes of analgesics in healthy subjects. The analgesic compounds all showed a unique pro fi le in their effects on the pain tasks

[1]  G. Groeneveld,et al.  Determining Pain Detection and Tolerance Thresholds Using an Integrated, Multi-Modal Pain Task Battery , 2016, Journal of visualized experiments : JoVE.

[2]  Christopher Southan,et al.  The Concise Guide to PHARMACOLOGY 2015/16: Voltage‐gated ion channels , 2015, British journal of pharmacology.

[3]  Christopher Southan,et al.  The Concise Guide to PHARMACOLOGY 2015/16: Ligand‐gated ion channels , 2015, British journal of pharmacology.

[4]  Christopher Southan,et al.  The Concise Guide to PHARMACOLOGY 2015/16: G protein‐coupled receptors , 2015, British journal of pharmacology.

[5]  Christopher Southan,et al.  The Concise Guide to PHARMACOLOGY 2015/16: Enzymes , 2015, British journal of pharmacology.

[6]  Joanna L. Sharman,et al.  The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands , 2015, Nucleic Acids Res..

[7]  J. V. van Gerven,et al.  The use of biomarkers in human pharmacology (Phase I) studies. , 2015, Annual review of pharmacology and toxicology.

[8]  A. Drewes,et al.  Sensitivity of quantitative sensory models to morphine analgesia in humans , 2014, Journal of pain research.

[9]  Y. Boyle,et al.  The effect of a combination of gabapentin and donepezil in an experimental pain model in healthy volunteers: Results of a randomized controlled trial , 2014, PAIN®.

[10]  D. Bouhassira,et al.  Relationships between the paradoxical painful and nonpainful sensations induced by a thermal grill , 2014, PAIN®.

[11]  A. Ultsch,et al.  Human models of pain for the prediction of clinical analgesia , 2014, PAIN®.

[12]  P. Wiffen,et al.  Imipramine for neuropathic pain in adults. , 2014, The Cochrane database of systematic reviews.

[13]  T. Bisogno,et al.  Latest advances in the discovery of fatty acid amide hydrolase inhibitors , 2013, Expert opinion on drug discovery.

[14]  L. Arendt-Nielsen,et al.  Evaluation of Anti-Hyperalgesic and Analgesic Effects of Two Benzodiazepines in Human Experimental Pain: A Randomized Placebo-Controlled Study , 2013, PloS one.

[15]  Jörn Lötsch,et al.  Clinical pharmacology of analgesics assessed with human experimental pain models: bridging basic and clinical research , 2013, British journal of pharmacology.

[16]  P. Neuvonen,et al.  Rifampicin has a Profound Effect on the Pharmacokinetics of Oral S‐Ketamine and Less on Intravenous S‐Ketamine , 2012, Basic & clinical pharmacology & toxicology.

[17]  Lasse P. Malver,et al.  A Double-blind, Placebo-controlled Study on the Effect of Buprenorphine and Fentanyl on Descending Pain Modulation: A Human Experimental Study , 2012, The Clinical journal of pain.

[18]  Asbjørn Mohr Drewes,et al.  Human Experimental Pain Models for Assessing the Therapeutic Efficacy of Analgesic Drugs , 2012, Pharmacological Reviews.

[19]  Erik Olofsen,et al.  Pharmacokinetic–pharmacodynamic modeling in acute and chronic pain: an overview of the recent literature , 2011, Expert review of clinical pharmacology.

[20]  C. Graversen,et al.  Randomised clinical trial: pregabalin attenuates experimental visceral pain through sub‐cortical mechanisms in patients with painful chronic pancreatitis , 2011, Alimentary pharmacology & therapeutics.

[21]  T. Cummins,et al.  Recent Developments Regarding Voltage-Gated Sodium Channel Blockers for the Treatment of Inherited and Acquired Neuropathic Pain Syndromes , 2011, Front. Pharmacol..

[22]  A. Banerjee,et al.  Efficacy of pregabalin in acute postoperative pain: a meta-analysis. , 2011, British journal of anaesthesia.

[23]  R. Fillingim,et al.  Effect of ketamine on endogenous pain modulation in healthy volunteers , 2011, PAIN®.

[24]  G. Dussor,et al.  Central modulation of pain. , 2010, The Journal of clinical investigation.

[25]  B. Corrigan,et al.  Clinical Pharmacokinetics of Pregabalin in Healthy Volunteers , 2010, Journal of clinical pharmacology.

[26]  L. Arendt-Nielsen,et al.  Assessing efficacy of non-opioid analgesics in experimental pain models in healthy volunteers: an updated review. , 2009, British journal of clinical pharmacology.

[27]  Asbjørn Mohr Drewes,et al.  Assessing analgesic actions of opioids by experimental pain models in healthy volunteers - an updated review. , 2009, British journal of clinical pharmacology.

[28]  S. McMahon,et al.  Ultraviolet‐B induced inflammation of human skin: Characterisation and comparison with traditional models of hyperlagesia , 2009, European journal of pain.

[29]  Yelena Granovsky,et al.  The methodology of experimentally induced diffuse noxious inhibitory control (DNIC)-like effect in humans , 2009, PAIN®.

[30]  Delphine Kern,et al.  Effects of morphine on the experimental illusion of pain produced by a thermal grill , 2008, PAIN.

[31]  D. Bouhassira,et al.  Pharmacological dissection of the paradoxical pain induced by a thermal grill , 2008, PAIN.

[32]  J. Farrar,et al.  Pharmacologic management of neuropathic pain: Evidence-based recommendations , 2007, PAIN.

[33]  Anders Blomqvist,et al.  Pain sensations to the cold pressor test in normally menstruating women: comparison with men and relation to menstrual phase and serum sex steroid levels. , 2007, American journal of physiology. Regulatory, integrative and comparative physiology.

[34]  L. Arendt-Nielsen,et al.  Effects of Gabapentin on Experimental Somatic Pain and Temporal Summation , 2007, Regional Anesthesia & Pain Medicine.

[35]  Asbjørn Mohr Drewes,et al.  Multi-modal and tissue-differentiated experimental pain assessment: reproducibility of a new concept for assessment of analgesics. , 2006, Basic & clinical pharmacology & toxicology.

[36]  Erik Olofsen,et al.  Alfentanil and Placebo Analgesia: No Sex Differences Detected in Models of Experimental Pain , 2005, Anesthesiology.

[37]  F. Morain,et al.  Investigation of the paradoxical painful sensation (‘illusion of pain’) produced by a thermal grill , 2005, Pain.

[38]  R. Kapil,et al.  Pharmacokinetic properties of combination oxycodone plus racemic ibuprofen: two randomized, open-label, crossover studies in healthy adult volunteers. , 2004, Clinical therapeutics.

[39]  Erik Olofsen,et al.  Simultaneous Measurement and Integrated Analysis of Analgesia and Respiration after an Intravenous Morphine Infusion , 2004, Anesthesiology.

[40]  T. Sycha,et al.  The Effects of Remifentanil and Gabapentin on Hyperalgesia in a New Extended Inflammatory Skin Pain Model in Healthy Volunteers , 2004, Anesthesia and analgesia.

[41]  Lars Arendt-Nielsen,et al.  Pressure-pain function in desensitized and hypersensitized muscle and skin assessed by cuff algometry. , 2002, The journal of pain : official journal of the American Pain Society.

[42]  L. Arendt-Nielsen,et al.  The analgesic effect of codeine as compared to imipramine in different human experimental pain models , 2001, Pain.

[43]  D. DeMets,et al.  Biomarkers and surrogate endpoints: Preferred definitions and conceptual framework , 2001, Clinical pharmacology and therapeutics.

[44]  F. Kamali,et al.  Analgesic effects of lamotrigine and phenytoin on cold-induced pain: a crossover placebo-controlled study in healthy volunteers , 1998, Pain.

[45]  M. Eichelbaum,et al.  Same incidence of adverse drug events after codeine administration irrespective of the genetically determined differences in morphine formation , 1998, Pain.

[46]  R. Moore,et al.  Morphine and ibuprofen compared using the cold pressor test , 1988, Pain.

[47]  D. Ciraulo,et al.  Clinical pharmacokinetics of imipramine and desipramine in alcoholics and normal volunteers , 1988, Clinical pharmacology and therapeutics.

[48]  D. McClain,et al.  Intravenous fentanyl kinetics , 1980, Clinical pharmacology and therapeutics.

[49]  Ramsin M. Benyamin,et al.  Anti-nerve growth factor in the treatment of low back pain and radiculopathy: a systematic review and a meta-analysis. , 2014, Pain physician.

[50]  L. Arendt-Nielsen,et al.  Human experimental pain models in drug development: translational pain research. , 2007, Current opinion in investigational drugs.

[51]  P. Morselli,et al.  Clinical pharmacokinetics of antiepileptic drugs in adults. , 1980, Pharmacology & therapeutics.