Computational modeling of dendrites.

Computational methods have been part of neuroscience for many years. For example, models developed with these methods have provided a theory that helps explain the action potential. More recently, as experimental patch-electrode techniques have revealed new biophysics related to dendritic function and synaptic integration, computational models of dendrites have been developed to explain and further illuminate these results, and to predict possible additional behavior. Here, a collection of computational models of dendrites is reviewed. The goal is to help explain how such computational techniques work, some of their limitations, and what one can hope to learn about dendrites by modeling them.

[1]  Bartlett W. Mel,et al.  Computational subunits in thin dendrites of pyramidal cells , 2004, Nature Neuroscience.

[2]  N. Spruston,et al.  Action potential initiation and backpropagation in neurons of the mammalian CNS , 1997, Trends in Neurosciences.

[3]  B. Sakmann,et al.  Dendritic mechanisms underlying the coupling of the dendritic with the axonal action potential initiation zone of adult rat layer 5 pyramidal neurons , 2001, The Journal of physiology.

[4]  M L Hines,et al.  Neuron: A Tool for Neuroscientists , 2001, The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry.

[5]  Charles Jennings,et al.  Computational approaches to brain function , 2000, Nature Neuroscience.

[6]  Michele Migliore,et al.  Role of an A-Type K+ Conductance in the Back-Propagation of Action Potentials in the Dendrites of Hippocampal Pyramidal Neurons , 1999, Journal of Computational Neuroscience.

[7]  Bartlett W. Mel,et al.  Pyramidal Neuron as Two-Layer Neural Network , 2003, Neuron.

[8]  M. Larkum,et al.  High I(h) channel density in the distal apical dendrite of layer V pyramidal cells increases bidirectional attenuation of EPSPs. , 2001, Journal of neurophysiology.

[9]  G. Stuart,et al.  Site independence of EPSP time course is mediated by dendritic I(h) in neocortical pyramidal neurons. , 2000, Journal of neurophysiology.

[10]  T. Sejnowski,et al.  [Letters to nature] , 1996, Nature.

[11]  B. Sakmann,et al.  A new cellular mechanism for coupling inputs arriving at different cortical layers , 1999, Nature.

[12]  J. Magee Dendritic Hyperpolarization-Activated Currents Modify the Integrative Properties of Hippocampal CA1 Pyramidal Neurons , 1998, The Journal of Neuroscience.

[13]  M Migliore,et al.  Dendritic potassium channels in hippocampal pyramidal neurons , 2000, The Journal of physiology.

[14]  D. Johnston,et al.  K+ channel regulation of signal propagation in dendrites of hippocampal pyramidal neurons , 1997, Nature.

[15]  H. Markram,et al.  Regulation of Synaptic Efficacy by Coincidence of Postsynaptic APs and EPSPs , 1997, Science.

[16]  Bartlett W. Mel,et al.  Dendrites: bug or feature? , 2003, Current Opinion in Neurobiology.

[17]  Andreas T. Schaefer,et al.  Coincidence detection in pyramidal neurons is tuned by their dendritic branching pattern. , 2003, Journal of neurophysiology.

[18]  D. Johnston,et al.  Distance-dependent modifiable threshold for action potential back-propagation in hippocampal dendrites. , 2003, Journal of neurophysiology.

[19]  D. Jaffe,et al.  Passive normalization of synaptic integration influenced by dendritic architecture. , 1999, Journal of neurophysiology.

[20]  N. Spruston,et al.  Determinants of Voltage Attenuation in Neocortical Pyramidal Neuron Dendrites , 1998, The Journal of Neuroscience.

[21]  B. Sakmann,et al.  Patch-clamp recordings from the soma and dendrites of neurons in brain slices using infrared video microscopy , 1993, Pflügers Archiv.

[22]  Daniel Johnston,et al.  LTP is accompanied by an enhanced local excitability of pyramidal neuron dendrites , 2004, Nature Neuroscience.

[23]  Gábor Tamás,et al.  Polarized and compartment-dependent distribution of HCN1 in pyramidal cell dendrites , 2002, Nature Neuroscience.

[24]  A. Hodgkin,et al.  A quantitative description of membrane current and its application to conduction and excitation in nerve , 1952, The Journal of physiology.

[25]  Nace L. Golding,et al.  Compartmental Models Simulating a Dichotomy of Action Potential Backpropagation in Ca1 Pyramidal Neuron Dendrites , 2001, Journal of neurophysiology.

[26]  J. Schiller,et al.  NMDA spikes in basal dendrites of cortical pyramidal neurons , 2000, Nature.

[27]  M. Häusser,et al.  Propagation of action potentials in dendrites depends on dendritic morphology. , 2001, Journal of neurophysiology.

[28]  D. Johnston,et al.  A Synaptically Controlled, Associative Signal for Hebbian Plasticity in Hippocampal Neurons , 1997, Science.

[29]  Yitzhak Schiller,et al.  NMDA receptor-mediated dendritic spikes and coincident signal amplification , 2001, Current Opinion in Neurobiology.

[30]  Nace L. Golding,et al.  Dendritic spikes as a mechanism for cooperative long-term potentiation , 2002, Nature.

[31]  James M. Bower,et al.  The Book of GENESIS , 1994, Springer New York.

[32]  Idan Segev,et al.  The theoretical foundation of dendritic function: Selected papers of Wilfrid Rall with commentaries , 1994 .

[33]  R. C Cannon,et al.  An on-line archive of reconstructed hippocampal neurons , 1998, Journal of Neuroscience Methods.

[34]  N T Carnevale,et al.  Comparative electrotonic analysis of three classes of rat hippocampal neurons. , 1997, Journal of neurophysiology.