Caveolin-1 abrogates TGF-β mediated hepatocyte apoptosis

[1]  G. Muscat,et al.  Caveolin‐1 orchestrates the balance between glucose and lipid‐dependent energy metabolism: Implications for liver regeneration , 2012, Hepatology.

[2]  I. Ng,et al.  Caveolin‐1 overexpression is associated with hepatocellular carcinoma tumourigenesis and metastasis , 2012, The Journal of pathology.

[3]  Xin Zhou,et al.  PI3K/Akt signaling requires spatial compartmentalization in plasma membrane microdomains , 2011, Proceedings of the National Academy of Sciences.

[4]  C. Meyer,et al.  Distinct role of endocytosis for Smad and non-Smad TGF-β signaling regulation in hepatocytes. , 2011, Journal of hepatology.

[5]  I. Fabregat,et al.  The transforming growth factor‐beta (TGF‐β) mediates acquisition of a mesenchymal stem cell‐like phenotype in human liver cells , 2011, Journal of cellular physiology.

[6]  J. Balsinde,et al.  Caveolin-1 Deficiency Causes Cholesterol-Dependent Mitochondrial Dysfunction and Apoptotic Susceptibility , 2011, Current Biology.

[7]  J. M. Ryu,et al.  Involvement of caveolin‐1 in fibronectin‐induced mouse embryonic stem cell proliferation: Role of FAK, RhoA, PI3K/Akt, and ERK 1/2 pathways , 2011, Journal of cellular physiology.

[8]  C. Chai,et al.  Increased caveolin‐1 expression associated with prolonged overall survival rate in hepatocellular carcinoma , 2010, Pathology.

[9]  K. Iwaisako,et al.  Hepatocytes do not undergo epithelial‐mesenchymal transition in liver fibrosis in mice , 2010, Hepatology.

[10]  R. Derynck,et al.  New regulatory mechanisms of TGF-beta receptor function. , 2009, Trends in cell biology.

[11]  E. Neilson,et al.  Biomarkers for epithelial-mesenchymal transitions. , 2009, The Journal of clinical investigation.

[12]  C. Meyer,et al.  Extracellular matrix modulates sensitivity of hepatocytes to fibroblastoid dedifferentiation and transforming growth factor β–induced apoptosis , 2009, Hepatology.

[13]  J. Dennis,et al.  Lattices, rafts, and scaffolds: domain regulation of receptor signaling at the plasma membrane , 2009, The Journal of cell biology.

[14]  O. Sagol,et al.  Differential expression of Caveolin-1 in hepatocellular carcinoma: correlation with differentiation state, motility and invasion , 2009, BMC Cancer.

[15]  I. Fabregat,et al.  Upregulation of the NADPH oxidase NOX4 by TGF-beta in hepatocytes is required for its pro-apoptotic activity. , 2008, Journal of hepatology.

[16]  G. Wildey,et al.  TGFβ‐mediated BIM expression and apoptosis are regulated through SMAD3‐dependent expression of the MAPK phosphatase MKP2 , 2008, EMBO reports.

[17]  S. Dooley,et al.  Hepatocyte-specific Smad7 expression attenuates TGF-beta-mediated fibrogenesis and protects against liver damage. , 2008, Gastroenterology.

[18]  J. Chung,et al.  Caveolin-1 increases basal and TGF-beta1-induced expression of type I procollagen through PI-3 kinase/Akt/mTOR pathway in human dermal fibroblasts. , 2008, Cellular signalling.

[19]  Liang Zhang,et al.  Identification of the gene transcription and apoptosis mediated by TGF‐β‐Smad2/3‐Smad4 signaling , 2008, Journal of cellular physiology.

[20]  J. Dennis,et al.  Plasma membrane domain organization regulates EGFR signaling in tumor cells , 2007, The Journal of cell biology.

[21]  S. Dooley,et al.  Profibrogenic transforming growth factor‐β/activin receptor–like kinase 5 signaling via connective tissue growth factor expression in hepatocytes , 2007, Hepatology.

[22]  H. Tsukamoto,et al.  Iron Causes Interactions of TAK1, p21ras, and Phosphatidylinositol 3-Kinase in Caveolae to Activate IκB Kinase in Hepatic Macrophages* , 2007, Journal of Biological Chemistry.

[23]  M. Lindsay,et al.  Cholesterol‐Induced Caveolin Targeting to Lipid Droplets in Adipocytes: A Role for Caveolar Endocytosis , 2006, Traffic.

[24]  J. Lee,et al.  Protein Phosphatase 2A Regulates bim Expression via the Akt/FKHRL1 Signaling Pathway in Amyloid-β Peptide-Induced Cerebrovascular Endothelial Cell Death , 2006, The Journal of Neuroscience.

[25]  G. Wildey,et al.  Evidence That Ser87 of BimEL Is Phosphorylated by Akt and Regulates BimEL Apoptotic Function* , 2006, Journal of Biological Chemistry.

[26]  I. Fabregat,et al.  Involvement of EGF receptor and c-Src in the survival signals induced by TGF-β1 in hepatocytes , 2005, Oncogene.

[27]  A. Sánchez-Capelo Dual role for TGF-β1 in apoptosis , 2005 .

[28]  Yigong Shi Faculty Opinions recommendation of Akt interacts directly with Smad3 to regulate the sensitivity to TGF-beta induced apoptosis. , 2004 .

[29]  K. Luo,et al.  Akt interacts directly with Smad3 to regulate the sensitivity to TGF-β-induced apoptosis , 2004, Nature Cell Biology.

[30]  S. Dooley,et al.  Roles of TGF-beta in hepatic fibrosis. , 2002, Frontiers in bioscience : a journal and virtual library.

[31]  Yi-Hsien Su,et al.  Suppression of transforming growth factor-β-induced apoptosis through a phosphatidylinositol 3-kinase/Akt-dependent pathway , 1998, Oncogene.

[32]  P. Oh,et al.  Organized Endothelial Cell Surface Signal Transduction in Caveolae Distinct from Glycosylphosphatidylinositol-anchored Protein Microdomains* , 1997, The Journal of Biological Chemistry.

[33]  Richard G. W. Anderson,et al.  Localization of Platelet-derived Growth Factor-stimulated Phosphorylation Cascade to Caveolae (*) , 1996, The Journal of Biological Chemistry.

[34]  Steven Dooley,et al.  TGF-beta signaling in alcohol induced hepatic injury. , 2010, Frontiers in bioscience.

[35]  Ye-Guang Chen Endocytic regulation of TGF-β signaling , 2009, Cell Research.

[36]  G. Wildey,et al.  Transforming growth factor beta (TGFbeta)-induced apoptosis: the rise & fall of Bim. , 2009, Cell cycle.

[37]  T. Sjöblom,et al.  Sustained TGF beta exposure suppresses Smad and non-Smad signalling in mammary epithelial cells, leading to EMT and inhibition of growth arrest and apoptosis. , 2008, Oncogene.

[38]  A. Sorkin,et al.  Endocytosis and intracellular trafficking of ErbBs. , 2008, Experimental cell research.

[39]  J. Downward,et al.  Upregulation of two BH3-only proteins, Bmf and Bim, during TGF beta-induced apoptosis. , 2007, Oncogene.

[40]  A. Sánchez-Capelo Dual role for TGF-beta1 in apoptosis. , 2005, Cytokine & growth factor reviews.

[41]  J. Wrana,et al.  Distinct endocytic pathways regulate TGF-beta receptor signalling and turnover. , 2003, Nature cell biology.

[42]  R. H. Chen,et al.  Suppression of transforming growth factor-beta-induced apoptosis through a phosphatidylinositol 3-kinase/Akt-dependent pathway. , 1998, Oncogene.