Poor-quality red blood cell labelling with technetium-99m: case report and review of the literature

Technetium-99m red blood cell (RBC) venography is a simple and sensitive technique for the diagnosis of deep vein thrombosis of the lower limb, but optimal labelling of the blood pool is essential for a diagnostic study. Here we report the case of a 44-year-old male with deep vein thrombosis of the right leg. RBC venography of the lower extremities showed poor labelling. In addition we review the literature on the subject.

[1]  S. Srivastava,et al.  Radionuclide-labeled red blood cells: current status and future prospects. , 1984, Seminars in nuclear medicine.

[2]  P Richards,et al.  Cardiac chamber imaging: a comparison of red blood cells labeled with Tc-99m in vitro and in vivo. , 1978, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[3]  H. Dworkin,et al.  Acid-citrate-dextrose compared with heparin in the preparation of in vivo/in vitro technetium-99m red blood cells. , 1983, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[4]  C. Rabito,et al.  Radiolabeling of erythrocytes with technetium-99m: role of band-3 protein in the transport of pertechnetate across the cell membrane. , 1990, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[5]  M. Blaufox,et al.  Left ventricular ejection fraction and its response to therapy in essential hypertension. , 1981, Nephron.

[6]  R. Hicks,et al.  Efficiency of labelling of red blood cells with technetium-99m after dipyridamole infusion for thallium-201 stress testing , 1992, European Journal of Nuclear Medicine.

[7]  W. W. Miller,et al.  Pitfall to Modified In Vivo Method of Technetium–99m Red Blood Cell Labeling: lodinated Contrast Media , 1983, Clinical nuclear medicine.

[8]  J P Wexler,et al.  Pharmacologic alterations in Tc-99m binding by red blood cells: concise communication. , 1983, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[9]  B. Rhodes,et al.  Drug-induced changes in the biologic distribution of radiopharmaceuticals. , 1982, Seminars in nuclear medicine.