Chemical approaches to stem cell biology and therapeutics.

[1]  H. Deng,et al.  Pluripotent Stem Cells Induced from Mouse Somatic Cells by Small-Molecule Compounds , 2013, Science.

[2]  Jia Wang,et al.  Highly efficient induction and long-term maintenance of multipotent cardiovascular progenitors from human pluripotent stem cells under defined conditions , 2013, Cell Research.

[3]  Timothy J. Laurent,et al.  Conversion of Human Fibroblasts to Functional Endothelial Cells by Defined Factors , 2013, Arteriosclerosis, thrombosis, and vascular biology.

[4]  O. Yanuka,et al.  Selective elimination of human pluripotent stem cells by an oleate synthesis inhibitor discovered in a high-throughput screen. , 2013, Cell stem cell.

[5]  H. Okano,et al.  Notch Inhibition Induces Cochlear Hair Cell Regeneration and Recovery of Hearing after Acoustic Trauma , 2013, Neuron.

[6]  M. Suematsu,et al.  Regulation of glycolysis by Pdk functions as a metabolic checkpoint for cell cycle quiescence in hematopoietic stem cells. , 2013, Cell stem cell.

[7]  V. Wilson,et al.  In Vivo differentiation potential of epiblast stem cells revealed by chimeric embryo formation. , 2012, Cell reports.

[8]  Norio Nakatsuji,et al.  A small molecule that promotes cardiac differentiation of human pluripotent stem cells under defined, cytokine- and xeno-free conditions. , 2012, Cell reports.

[9]  H. Broxmeyer,et al.  Dipeptidylpeptidase 4 negatively regulates colony-stimulating factor activity and stress hematopoiesis , 2012, Nature Medicine.

[10]  Timothy J. Nelson,et al.  Metabolic plasticity in stem cell homeostasis and differentiation. , 2012, Cell stem cell.

[11]  G. Daley,et al.  Metabolic regulation in pluripotent stem cells during reprogramming and self-renewal. , 2012, Cell stem cell.

[12]  Jing Wang,et al.  Metformin activates an atypical PKC-CBP pathway to promote neurogenesis and enhance spatial memory formation. , 2012, Cell stem cell.

[13]  S. Shi,et al.  Combined small molecule inhibition accelerates developmental timing and converts human pluripotent stem cells into nociceptors , 2012, Nature Biotechnology.

[14]  D. Kaplan,et al.  Mobilizing endogenous stem cells for repair and regeneration: are we there yet? , 2012, Cell stem cell.

[15]  Sean P. Palecek,et al.  Robust cardiomyocyte differentiation from human pluripotent stem cells via temporal modulation of canonical Wnt signaling , 2012, Proceedings of the National Academy of Sciences.

[16]  Peter G. Schultz,et al.  A Stem Cell–Based Approach to Cartilage Repair , 2012, Science.

[17]  M. Gunzer,et al.  Cdc42 activity regulates hematopoietic stem cell aging and rejuvenation. , 2012, Cell stem cell.

[18]  Xiaoxia Qi,et al.  Heart repair by reprogramming non-myocytes with cardiac transcription factors , 2012, Nature.

[19]  Peter Wernet,et al.  Small molecules enable highly efficient neuronal conversion of human fibroblasts , 2012, Nature Methods.

[20]  A. Wagers,et al.  The stem cell niche in regenerative medicine. , 2012, Cell stem cell.

[21]  Dong Wook Han,et al.  Direct reprogramming of fibroblasts into neural stem cells by defined factors. , 2012, Cell stem cell.

[22]  M. Rosenfeld,et al.  Versatile pathway-centric approach based on high-throughput sequencing to anticancer drug discovery , 2012, Proceedings of the National Academy of Sciences.

[23]  P. Park,et al.  Ascorbic acid prevents loss of Dlk1-Dio3 imprinting and facilitates generation of all-iPS cell mice from terminally differentiated B cells , 2012, Nature Genetics.

[24]  E. Lander,et al.  Chromatin modifying enzymes as modulators of reprogramming , 2012, Nature.

[25]  G. Pan,et al.  The histone demethylases Jhdm1a/1b enhance somatic cell reprogramming in a vitamin-C-dependent manner. , 2011, Cell stem cell.

[26]  D. Srivastava,et al.  Abstract 10466: In Vivo Reprogramming of Murine Cardiac Fibroblasts into Induced Cardiomyocytes , 2011, Circulation.

[27]  P. Schultz,et al.  Stepwise Chemically Induced Cardiomyocyte Specification of Human Embryonic Stem Cells , 2011 .

[28]  D. Surmeier,et al.  Floor plate-derived dopamine neurons from hESCs efficiently engraft in animal models of PD , 2011, Nature.

[29]  Lia S. Campos,et al.  Rapid and efficient reprogramming of somatic cells to induced pluripotent stem cells by retinoic acid receptor gamma and liver receptor homolog 1 , 2011, Proceedings of the National Academy of Sciences.

[30]  Maria Teresa Dell'Anno,et al.  Direct generation of functional dopaminergic neurons from mouse and human fibroblasts , 2011, Nature.

[31]  R. Tsien,et al.  MicroRNA-mediated conversion of human fibroblasts to neurons , 2011, Nature.

[32]  Andre Terzic,et al.  Somatic oxidative bioenergetics transitions into pluripotency-dependent glycolysis to facilitate nuclear reprogramming. , 2011, Cell metabolism.

[33]  Sayaka Sekiya,et al.  Direct conversion of mouse fibroblasts to hepatocyte-like cells by defined factors , 2011, Nature.

[34]  L. Hui,et al.  Induction of functional hepatocyte-like cells from mouse fibroblasts by defined factors , 2011, Nature.

[35]  A. Edge,et al.  Notch Signaling Alters Sensory or Neuronal Cell Fate Specification of Inner Ear Stem Cells , 2011, The Journal of Neuroscience.

[36]  Ulrich Pfisterer,et al.  Direct conversion of human fibroblasts to dopaminergic neurons , 2011, Proceedings of the National Academy of Sciences.

[37]  J. Adjaye,et al.  A Cyclic AMP Analog, 8-Br-cAMP, Enhances the Induction of Pluripotency in Human Fibroblast Cells , 2011, Stem Cell Reviews and Reports.

[38]  Thomas Vierbuchen,et al.  Induction of human neuronal cells by defined transcription factors , 2011, Nature.

[39]  R. Jaenisch,et al.  Pan-Src family kinase inhibitors replace Sox2 during the direct reprogramming of somatic cells. , 2011, Angewandte Chemie.

[40]  Woong Sun,et al.  Rapid induction and long-term self-renewal of primitive neural precursors from human embryonic stem cells by small molecule inhibitors , 2011, Proceedings of the National Academy of Sciences.

[41]  S. Lipton,et al.  Direct reprogramming of mouse fibroblasts to neural progenitors , 2011, Proceedings of the National Academy of Sciences.

[42]  Wen-lin Li,et al.  Human Pluripotent Stem Cells: Decoding the Naïve State , 2011, Science Translational Medicine.

[43]  G. Wang,et al.  Conversion of mouse fibroblasts into cardiomyocytes using a direct reprogramming strategy , 2011, Nature Cell Biology.

[44]  S. McKnight,et al.  Development of proneurogenic, neuroprotective small molecules. , 2011, Journal of the American Chemical Society.

[45]  Sheng Ding,et al.  Reprogramming of human primary somatic cells by OCT4 and chemical compounds. , 2010, Cell stem cell.

[46]  A. Sengupta,et al.  Pharmacological inhibition of EGFR signaling enhances G-CSF–induced hematopoietic stem cell mobilization , 2010, Nature Medicine.

[47]  Anthony E. Boitano,et al.  Aryl Hydrocarbon Receptor Antagonists Promote the Expansion of Human Hematopoietic Stem Cells , 2010, Science.

[48]  N. Sato,et al.  Non-muscle myosin II regulates survival threshold of pluripotent stem cells. , 2010, Nature communications.

[49]  H. Schöler,et al.  Conversion of Mouse Epiblast Stem Cells to an Earlier Pluripotency State by Small Molecules* , 2010, The Journal of Biological Chemistry.

[50]  Yoshiki Sasai,et al.  Molecular pathway and cell state responsible for dissociation-induced apoptosis in human pluripotent stem cells. , 2010, Cell stem cell.

[51]  J. Thomson,et al.  Actin-myosin contractility is responsible for the reduced viability of dissociated human embryonic stem cells. , 2010, Cell stem cell.

[52]  V. Vedantham,et al.  Direct Reprogramming of Fibroblasts into Functional Cardiomyocytes by Defined Factors , 2010, Cell.

[53]  Jiuhong Kang,et al.  E‐Cadherin‐Mediated Cell–Cell Contact Is Critical for Induced Pluripotent Stem Cell Generation , 2010, Stem cells.

[54]  Takahiro Ochiya,et al.  Generation of genetically modified rats from embryonic stem cells , 2010, Proceedings of the National Academy of Sciences.

[55]  D. Brat,et al.  Discovery of a Proneurogenic, Neuroprotective Chemical , 2010, Cell.

[56]  C. Lengner,et al.  Human embryonic stem cells with biological and epigenetic characteristics similar to those of mouse ESCs , 2010, Proceedings of the National Academy of Sciences.

[57]  Wanguo Wei,et al.  Revealing a core signaling regulatory mechanism for pluripotent stem cell survival and self-renewal by small molecules , 2010, Proceedings of the National Academy of Sciences.

[58]  M. Tomishima,et al.  Efficient derivation of functional floor plate tissue from human embryonic stem cells. , 2010, Cell stem cell.

[59]  S. Baylin,et al.  Butyrate Greatly Enhances Derivation of Human Induced Pluripotent Stem Cells by Promoting Epigenetic Remodeling and the Expression of Pluripotency‐Associated Genes , 2010, Stem cells.

[60]  Sunia A Trauger,et al.  Metabolic oxidation regulates embryonic stem cell differentiation , 2010, Nature chemical biology.

[61]  M. Huss,et al.  The nuclear receptor Nr5a2 can replace Oct4 in the reprogramming of murine somatic cells to pluripotent cells. , 2010, Cell stem cell.

[62]  Thomas Vierbuchen,et al.  Direct conversion of fibroblasts to functional neurons by defined factors , 2010, Nature.

[63]  H. Schöler,et al.  Generation of Human‐Induced Pluripotent Stem Cells in the Absence of Exogenous Sox2 , 2009, Stem cells.

[64]  David R. Liu,et al.  A small-molecule inhibitor of tgf-Beta signaling replaces sox2 in reprogramming by inducing nanog. , 2009, Cell stem cell.

[65]  K. Hochedlinger,et al.  Tgfβ Signal Inhibition Cooperates in the Induction of iPSCs and Replaces Sox2 and cMyc , 2009, Current Biology.

[66]  Sheng Ding,et al.  A chemical platform for improved induction of human iPSCs , 2009, Nature Methods.

[67]  B. Doble,et al.  GSK-3 is a master regulator of neural progenitor homeostasis , 2009, Nature Neuroscience.

[68]  J. Dipersio,et al.  BIO5192, a small molecule inhibitor of VLA-4, mobilizes hematopoietic stem and progenitor cells. , 2009, Blood.

[69]  C. Lengner,et al.  Metastable pluripotent states in NOD-mouse-derived ESCs. , 2009, Cell stem cell.

[70]  F. Wondisford,et al.  Metformin and Insulin Suppress Hepatic Gluconeogenesis through Phosphorylation of CREB Binding Protein , 2009, Cell.

[71]  S. Schreiber,et al.  Small molecules efficiently direct endodermal differentiation of mouse and human embryonic stem cells. , 2009, Cell stem cell.

[72]  Robert David,et al.  Synergy between CD26/DPP-IV inhibition and G-CSF improves cardiac function after acute myocardial infarction. , 2009, Cell stem cell.

[73]  S. Schreiber,et al.  A small molecule that directs differentiation of human ESCs into the pancreatic lineage. , 2009, Nature chemical biology.

[74]  J. Nichols,et al.  Klf4 reverts developmentally programmed restriction of ground state pluripotency , 2009, Development.

[75]  L. Zon,et al.  Genetic Interaction of PGE2 and Wnt Signaling Regulates Developmental Specification of Stem Cells and Regeneration , 2009, Cell.

[76]  M. Tomishima,et al.  Highly efficient neural conversion of human ES and iPS cells by dual inhibition of SMAD signaling , 2009, Nature Biotechnology.

[77]  S. Haggarty,et al.  Disrupted in Schizophrenia 1 Regulates Neuronal Progenitor Proliferation via Modulation of GSK3β/β-Catenin Signaling , 2009, Cell.

[78]  H. Deng,et al.  Pluripotin Combined with Leukemia Inhibitory Factor Greatly Promotes the Derivation of Embryonic Stem Cell Lines from Refractory Strains , 2009, Stem cells.

[79]  Sheng Ding,et al.  Generation of rat and human induced pluripotent stem cells by combining genetic reprogramming and chemical inhibitors. , 2009, Cell stem cell.

[80]  S. Rankin,et al.  Differential mobilization of subsets of progenitor cells from the bone marrow. , 2009, Cell stem cell.

[81]  C. Hsieh,et al.  Germline Competent Embryonic Stem Cells Derived from Rat Blastocysts , 2008, Cell.

[82]  Austin G Smith,et al.  Capture of Authentic Embryonic Stem Cells from Rat Blastocysts , 2008, Cell.

[83]  Sheng Ding,et al.  Induction of pluripotent stem cells from mouse embryonic fibroblasts by Oct4 and Klf4 with small-molecule compounds. , 2008, Cell stem cell.

[84]  Wenjun Guo,et al.  Induction of pluripotent stem cells from primary human fibroblasts with only Oct4 and Sox2 , 2008, Nature Biotechnology.

[85]  Hsu-hsin Chen,et al.  The Growth Factor Environment Defines Distinct Pluripotent Ground States in Novel Blastocyst-Derived Stem Cells , 2008, Cell.

[86]  Douglas A. Melton,et al.  In vivo reprogramming of adult pancreatic exocrine cells to β-cells , 2008, Nature.

[87]  Jennifer Nichols,et al.  Promotion of Reprogramming to Ground State Pluripotency by Signal Inhibition , 2008, PLoS biology.

[88]  Richard A Young,et al.  Wnt signaling promotes reprogramming of somatic cells to pluripotency. , 2008, Cell stem cell.

[89]  Wenjun Guo,et al.  Induction of pluripotent stem cells by defined factors is greatly improved by small-molecule compounds , 2008, Nature Biotechnology.

[90]  H. Schöler,et al.  A combined chemical and genetic approach for the generation of induced pluripotent stem cells. , 2008, Cell stem cell.

[91]  B. Doble,et al.  The ground state of embryonic stem cell self-renewal , 2008, Nature.

[92]  Sheng Ding,et al.  A chemical approach to stem-cell biology and regenerative medicine , 2008, Nature.

[93]  T. Graf,et al.  PU.1 and C/EBPα/β convert fibroblasts into macrophage-like cells , 2008, Proceedings of the National Academy of Sciences.

[94]  G. Tricot,et al.  AMD3100 plus G-CSF can successfully mobilize CD34+ cells from non-Hodgkin's lymphoma, Hodgkin's disease and multiple myeloma patients previously failing mobilization with chemotherapy and/or cytokine treatment: compassionate use data , 2008, Bone Marrow Transplantation.

[95]  R. McKay,et al.  New cell lines from mouse epiblast share defining features with human embryonic stem cells , 2007, Nature.

[96]  M. Trotter,et al.  Derivation of pluripotent epiblast stem cells from mammalian embryos , 2007, Nature.

[97]  L. Zon,et al.  Prostaglandin E2 regulates vertebrate haematopoietic stem cell homeostasis , 2007, Nature.

[98]  R. Moon,et al.  Biphasic role for Wnt/β-catenin signaling in cardiac specification in zebrafish and embryonic stem cells , 2007, Proceedings of the National Academy of Sciences.

[99]  S. Nishikawa,et al.  A ROCK inhibitor permits survival of dissociated human embryonic stem cells , 2007, Nature Biotechnology.

[100]  Karl Mechtler,et al.  Reversal of H3K9me2 by a small-molecule inhibitor for the G9a histone methyltransferase. , 2007, Molecular cell.

[101]  Linda Yang,et al.  Cdc42 GTPase-activating protein deficiency promotes genomic instability and premature aging-like phenotypes , 2007, Proceedings of the National Academy of Sciences.

[102]  I. Komuro,et al.  Developmental stage-specific biphasic roles of Wnt/β-catenin signaling in cardiomyogenesis and hematopoiesis , 2006, Proceedings of the National Academy of Sciences.

[103]  H. Schöler,et al.  Self-renewal of embryonic stem cells by a small molecule , 2006, Proceedings of the National Academy of Sciences.

[104]  H. Cedar,et al.  G9a-mediated irreversible epigenetic inactivation of Oct-3/4 during early embryogenesis , 2006, Nature Cell Biology.

[105]  J. Dipersio,et al.  The use of AMD3100 plus G-CSF for autologous hematopoietic progenitor cell mobilization is superior to G-CSF alone. , 2005, Blood.

[106]  H. Clevers,et al.  Wnt signalling in stem cells and cancer , 2005, Nature.

[107]  H. Broxmeyer,et al.  Modulation of Hematopoietic Stem Cell Homing and Engraftment by CD26 , 2004, Science.

[108]  B. Wood,et al.  Mobilization of hematopoietic progenitor cells in healthy volunteers by AMD3100, a CXCR4 antagonist. , 2003, Blood.

[109]  Eric J Topol,et al.  Effect of stromal-cell-derived factor 1 on stem-cell homing and tissue regeneration in ischaemic cardiomyopathy , 2003, The Lancet.

[110]  R. Taichman,et al.  G-CSF induces stem cell mobilization by decreasing bone marrow SDF-1 and up-regulating CXCR4 , 2002, Nature Immunology.

[111]  M. Mattson,et al.  Dietary restriction increases the number of newly generated neural cells, and induces BDNF expression, in the dentate gyrus of rats , 2000, Journal of Molecular Neuroscience.

[112]  F M Watt,et al.  Out of Eden: stem cells and their niches. , 2000, Science.

[113]  Qi Zhou,et al.  EMBRYONIC STEM CELLS/INDUCED PLURIPOTENT STEM CELLS Brief Report: Combined Chemical Treatment Enables Oct4-Induced Reprogramming from Mouse Embryonic Fibroblasts , 2011 .

[114]  R. Schugar,et al.  Small molecules in stem cell self-renewal and differentiation , 2008, Gene Therapy.

[115]  Brief Report Generation of Induced Pluripotent Stem Cells Using Recombinant Proteins , 2022 .