NTreceptorDB: a Database of Polymorphisms and Disease-Gene Associations in Behavioral Disorders

Genetic variation in neurotransmitter receptors have been shown to be associated with various behavioral and mental disorders. Presentation of dis- ease-neurotransmitter receptor relationship in a comprehensive manner would prove useful for future experimental as well as computational work. In this study, we approach the relationship of neurotransmitter receptors to mental and behavioral disorders from a biomedical text mining perspective. To this extent, we collected an initial set of known neurotransmitter receptors and mental dis- orders, and built an association by automated literature and text mining methods using Support Vector Machines. NTreceptorDB, a database that enables users to analyze association between neurotransmitter receptor and mental disorder data is developed. Abstracts available in NTreceptorDB show biomedical evi- dence for neurotransmitter receptor-disease association and are linked to Pub- Med. In particular, NTreceptorDB covers specific polymorphisms in neuro- transmitter receptor genes that are associated with diseases.

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