Analysis of the Efficacy and Safety of L-Glutamine Granules in Treating Severe Burn Patients

OBJECTIVE:To evaluate the clinical therapeutic effect of L-glutamine granules on intestinal damage of severe burn patients and the safty of the drug METHODS:Thirty-nine severe burn patients were randomly divided into two groups:control group(C group,nineteen patients)and L-glutamine treatment group(GLN group,twenty patients) GLN group patients were given L-glutamine in a dose of 30g per day for 7 days,and C group patients were given the same dosage of placebo for 7 days The plasma L-glutamine concentration,the degree of intestinal mucosa damage,blood biochemistry and complication were observed and wound healing rate of burn area was determined,then the length of hospital stay was recorded RESULTS:After 7 days of taking L-glutamine orally,plasma L-glutamine concentration in GLN group was significant higher than that in C group(P0 01) The degree of intestine damage and intestinal mucosal permeability in GLN group were lower than those in C group In addition,the wound healing rate was faster and the length of hospital stay was shorter in GLN group than those in C group CONCLUSION:Administration of L-glutamine could abate the degree of intestine damage obviously,lessen intestinal mucosal permeability,ameliorate wound healing rate and reduce the length of hospital stay