An electronic network for the surveillance of antimicrobial resistance in bacterial nosocomial isolates in Greece. The Greek Network for the Surveillance of Antimicrobial Resistance.

The present article reports an evaluation of the national electronic network for the continuous monitoring of antimicrobial resistance in Greece. The network employs a common electronic code and data format and uses WHONET software. Our four years' experience with the network confirms its practicality. A total of 22 hospitals in Greece are currently using the software, of which 19 participate in the network. Analysis of the information obtained has greatly helped in identifying the main factors responsible for the emergence of antimicrobial resistance in the participating hospitals. The data collected have also helped to identify priorities for further investigation of the genetic and molecular mechanisms responsible for the emergence of resistance and facilitated development of hospital-based empirical therapy of infections. In conclusion, the implementation of national networks for the surveillance of antimicrobial resistance should be regarded as a priority.

[1]  T. Pitt,et al.  Klebsiella pneumoniae infections in Greek hospitals. Dissemination of plasmids encoding an SHV-5 type beta-lactamase. , 1995, The Journal of hospital infection.

[2]  A. Tsakris,et al.  On the incidence of antibiotic resistance among aerobic gram-negative rods isolated in Greek hospitals. , 1993, The Journal of hospital infection.

[3]  M. Weinstein,et al.  Molecular epidemiology of macrolides-lincosamides-streptogramin B resistance in Staphylococcus aureus and coagulase-negative staphylococci , 1987, Antimicrobial Agents and Chemotherapy.

[4]  F. Baquero,et al.  Antibiotic resistance in Spain: what can be done? Task Force of the General Direction for Health Planning of the Spanish Ministry of Health. , 1996, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[5]  A. Philippon,et al.  Prevalence of a transferable SHV-5 type beta-lactamase in clinical isolates of Klebsiella pneumoniae and Escherichia coli in Greece. , 1990, The Journal of antimicrobial chemotherapy.

[6]  T. O'Brien,et al.  Surveillance of antimicrobial resistance: the WHONET program. , 1997, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[7]  T. F. O'Brien,et al.  WHONET: an information system for monitoring antimicrobial resistance. , 1995, Emerging infectious diseases.

[8]  D. Shlaes,et al.  The most frequent aminoglycoside resistance mechanisms--changes with time and geographic area: a reflection of aminoglycoside usage patterns? Aminoglycoside Resistance Study Groups. , 1997, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[9]  P. Courvalin Interpretive reading of in vitro antibiotic susceptibility tests (the antibiogramme). , 1996, Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases.

[10]  T. O'Brien,et al.  The global epidemic nature of antimicrobial resistance and the need to monitor and manage it locally. , 1997, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[11]  A. Tomasz,et al.  Multiple-antibiotic-resistant pathogenic bacteria. A report on the Rockefeller University Workshop. , 1994, The New England journal of medicine.

[12]  D. Greenwood,et al.  A GUIDE TO SENSITIVITY TESTING , 1991 .

[13]  Antibiotic resistance among gram-negative bacilli in 19 Greek hospitals. , 1989, The Journal of hospital infection.

[14]  A. Mentis,et al.  High prevalence of stably derepressed class-I beta-lactamase expression in multiresistant clinical isolates of Enterobacter cloacae from Greek hospitals. , 1992, Journal of medical microbiology.

[15]  P. Courvalin,et al.  Definition and determination of in vitro antibiotic susceptibility breakpoints for bacteria. , 1996, Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases.