Changes in body composition in patients with severe lipodystrophy after leptin replacement therapy.

[1]  N. Sharkey,et al.  Leptin and the skeleton , 2002, Clinical endocrinology.

[2]  J. Zerwekh,et al.  Effect of subcutaneous leptin replacement therapy on bone metabolism in patients with generalized lipodystrophy. , 2002, The Journal of clinical endocrinology and metabolism.

[3]  Graham M Lord,et al.  Beneficial effects of leptin on obesity, T cell hyporesponsiveness, and neuroendocrine/metabolic dysfunction of human congenital leptin deficiency. , 2002, The Journal of clinical investigation.

[4]  N. Socci,et al.  Role for Stearoyl-CoA Desaturase-1 in Leptin-Mediated Weight Loss , 2002, Science.

[5]  P. Gorden,et al.  Effect of leptin replacement on pituitary hormone regulation in patients with severe lipodystrophy. , 2002, The Journal of clinical endocrinology and metabolism.

[6]  K. Petersen,et al.  Leptin reverses insulin resistance and hepatic steatosis in patients with severe lipodystrophy. , 2002, The Journal of clinical investigation.

[7]  Y. Matsuzawa,et al.  Serum adiponectin and leptin levels in patients with lipodystrophies , 2002 .

[8]  S. Heymsfield,et al.  Low dose leptin administration reverses effects of sustained weight-reduction on energy expenditure and circulating concentrations of thyroid hormones. , 2002, The Journal of clinical endocrinology and metabolism.

[9]  M. Reitman,et al.  Leptin-replacement therapy for lipodystrophy. , 2002, The New England journal of medicine.

[10]  Young-Bum Kim,et al.  Leptin stimulates fatty-acid oxidation by activating AMP-activated protein kinase , 2002, Nature.

[11]  M. Reitman,et al.  Lipoatrophy syndromes: when ‘too little fat’ is a clinical problem , 2000, Pediatric diabetes.

[12]  C. Steppan,et al.  Leptin is a potent stimulator of bone growth in ob/ob mice , 2000, Regulatory Peptides.

[13]  C. Mantzoros Role of Leptin in Reproduction , 2000, Annals of the New York Academy of Sciences.

[14]  Arndt F Schilling,et al.  Leptin Inhibits Bone Formation through a Hypothalamic Relay A Central Control of Bone Mass , 2000, Cell.

[15]  K. Fujioka,et al.  Recombinant leptin for weight loss in obese and lean adults: a randomized, controlled, dose-escalation trial. , 1999, JAMA.

[16]  A. Prentice,et al.  Effects of recombinant leptin therapy in a child with congenital leptin deficiency. , 1999, The New England journal of medicine.

[17]  R. Hammer,et al.  Leptin reverses insulin resistance and diabetes mellitus in mice with congenital lipodystrophy , 1999, Nature.

[18]  J. Halaas,et al.  Leptin and the regulation of body weight in mammals , 1998, Nature.

[19]  R. Hammer,et al.  Insulin resistance and diabetes mellitus in transgenic mice expressing nuclear SREBP-1c in adipose tissue: model for congenital generalized lipodystrophy. , 1998, Genes & development.

[20]  M. Olive,et al.  Life without white fat: a transgenic mouse. , 1998, Genes & development.

[21]  A. Klibanski,et al.  Decreased leptin levels in normal weight women with hypothalamic amenorrhea: the effects of body composition and nutritional intake. , 1998, The Journal of clinical endocrinology and metabolism.

[22]  C. Burant,et al.  Troglitazone action is independent of adipose tissue. , 1997, The Journal of clinical investigation.

[23]  J. Flier,et al.  Leptin inhibition of the hypothalamic-pituitary-adrenal axis in response to stress. , 1997, Endocrinology.

[24]  K. Mounzih,et al.  Leptin treatment rescues the sterility of genetically obese ob/ob males. , 1997, Endocrinology.

[25]  C. Mantzoros,et al.  Role of leptin in the neuroendocrine response to fasting , 1996, Nature.

[26]  F. Chehab,et al.  Correction of the sterility defect in homozygous obese female mice by treatment with the human recombinant leptin , 1996, Nature Genetics.

[27]  R. Considine,et al.  Serum immunoreactive-leptin concentrations in normal-weight and obese humans. , 1996, The New England journal of medicine.

[28]  M. Maffei,et al.  Positional cloning of the mouse obese gene and its human homologue , 1994, Nature.

[29]  G Block,et al.  A data-based approach to diet questionnaire design and testing. , 1986, American journal of epidemiology.

[30]  B. Modan,et al.  Urinary Calcium Excretion in Relation to Kidney Function in the Adult , 1975, Journal of the American Geriatrics Society.

[31]  A. Garg,et al.  Effect of leptin replacement on intrahepatic and intramyocellular lipid content in patients with generalized lipodystrophy. , 2003, Diabetes care.