Inkjet printing for biosensor fabrication: combining chemistry and technology for advanced manufacturing.

Inkjet printing is emerging at the forefront of biosensor fabrication technologies. Parallel advances in both ink chemistry and printers have led to a biosensor manufacturing approach that is simple, rapid, flexible, high resolution, low cost, efficient for mass production, and extends the capabilities of devices beyond other manufacturing technologies. Here we review for the first time the factors behind successful inkjet biosensor fabrication, including printers, inks, patterning methods, and matrix types. We discuss technical considerations that are important when moving beyond theoretical knowledge to practical implementation. We also highlight significant advances in biosensor functionality that have been realised through inkjet printing. Finally, we consider future possibilities for biosensors enabled by this novel combination of chemistry and technology.

[1]  Babak Ziaie,et al.  Laser-treated hydrophobic paper: an inexpensive microfluidic platform. , 2011, Lab on a chip.

[2]  Eun Sok Kim,et al.  In situ DNA synthesis on glass substrate for microarray fabrication using self-focusing acoustic transducer , 2006, IEEE Transactions on Automation Science and Engineering.

[3]  Tuan Vo-Dinh,et al.  Microarray sampling-platform fabrication using bubble-jet technology for a biochip system , 2001, Fresenius' journal of analytical chemistry.

[4]  G. Whitesides,et al.  Low-cost printing of poly(dimethylsiloxane) barriers to define microchannels in paper. , 2008, Analytical chemistry.

[5]  Daniel Citterio,et al.  Inkjet printed (bio)chemical sensing devices , 2013, Analytical and Bioanalytical Chemistry.

[6]  Zhihong Nie,et al.  Programmable diagnostic devices made from paper and tape. , 2010, Lab on a chip.

[7]  Amin Famili,et al.  First drop dissimilarity in drop-on-demand inkjet devices , 2011 .

[8]  Laura Gonzalez-Macia,et al.  Advanced printing and deposition methodologies for the fabrication of biosensors and biodevices. , 2010, The Analyst.

[9]  Hermann Seitz,et al.  Ceramic scaffolds produced by computer-assisted 3D printing and sintering: characterization and biocompatibility investigations. , 2010, Journal of biomedical materials research. Part B, Applied biomaterials.

[10]  Frances S Ligler,et al.  Method for printing functional protein microarrays. , 2003, BioTechniques.

[11]  Bo Wu,et al.  Phase change inks , 2003 .

[12]  Shenguang Ge,et al.  Paper-based chemiluminescence ELISA: lab-on-paper based on chitosan modified paper device and wax-screen-printing. , 2012, Biosensors & bioelectronics.

[13]  Ning Yan,et al.  Piezoelectric Ink‐Jet Printing of Horseradish Peroxidase: Effect of Ink Viscosity Modifiers on Activity , 2007 .

[15]  George M Whitesides,et al.  FLASH: a rapid method for prototyping paper-based microfluidic devices. , 2008, Lab on a chip.

[16]  Robert Pelton,et al.  Effects of temperature and relative humidity on the stability of paper-immobilized antibodies. , 2012, Biomacromolecules.

[17]  Xu Li,et al.  A perspective on paper-based microfluidics: Current status and future trends. , 2012, Biomicrofluidics.

[18]  A. Facchetti,et al.  A high-mobility electron-transporting polymer for printed transistors , 2009, Nature.

[19]  J. Rogers,et al.  Nanoscale patterns of oligonucleotides formed by electrohydrodynamic jet printing with applications in biosensing and nanomaterials assembly. , 2008, Nano letters.

[20]  B. Khuri-Yakub,et al.  Nozzleless droplet formation with focused acoustic beams , 1989 .

[21]  Junfei Tian,et al.  Paper-based microfluidic devices by plasma treatment. , 2008, Analytical chemistry.

[22]  B Veigas,et al.  A low cost, safe, disposable, rapid and self-sustainable paper-based platform for diagnostic testing: lab-on-paper , 2014, Nanotechnology.

[23]  Peter Andresen,et al.  Characteristics of a piezoelectric pulsed nozzle beam , 1985 .

[24]  Oliver G. Harlen,et al.  Viscoelasticity in inkjet printing , 2010 .

[25]  H. Eickhoff,et al.  Development of a technology for automation and miniaturization of protein crystallization. , 2001, Journal of biotechnology.

[26]  H. Matsui,et al.  Inkjet printing of single-crystal films , 2011, Nature.

[27]  V. Subramanian,et al.  Inkjet-printed line morphologies and temperature control of the coffee ring effect. , 2008, Langmuir : the ACS journal of surfaces and colloids.

[28]  David B. Wallace,et al.  Applicatons of Ink-Jet Printing Technology to BioMEMS and Microfluidic Systems , 2001, MOEMS-MEMS.

[29]  R. Cattrall,et al.  The use of a polymer inclusion membrane in a paper-based sensor for the selective determination of Cu(II). , 2013, Analytica chimica acta.

[30]  W. Dungchai,et al.  A low-cost, simple, and rapid fabrication method for paper-based microfluidics using wax screen-printing. , 2011, The Analyst.

[31]  Bingcheng Lin,et al.  Rapid prototyping of paper‐based microfluidics with wax for low‐cost, portable bioassay , 2009, Electrophoresis.

[32]  Barbara Ballarin,et al.  An HRP-based amperometric biosensor fabricated by thermal inkjet printing , 2007 .

[33]  Wei Wang,et al.  Tree-shaped paper strip for semiquantitative colorimetric detection of protein with self-calibration. , 2010, Journal of chromatography. A.

[34]  Brian Derby,et al.  Ink Jet Deposition of Ceramic Suspensions: Modeling and Experiments of Droplet Formation , 2000 .

[35]  Claudia N. Hoth,et al.  Printing highly efficient organic solar cells. , 2008, Nano letters.

[36]  R. Stephenson A and V , 1962, The British journal of ophthalmology.

[37]  John A Rogers,et al.  High-resolution electrohydrodynamic jet printing. , 2007, Nature materials.

[38]  Wei Shen,et al.  Fabrication of paper-based microfluidic sensors by printing. , 2010, Colloids and surfaces. B, Biointerfaces.

[39]  D. Lewis,et al.  Ink-jet fabrication of electronic components , 2007 .

[40]  Wei W. Yu,et al.  Highly sensitive and flexible inkjet printed SERS sensors on paper. , 2013, Methods.

[41]  J. Vörös,et al.  Electrochemical Biosensors - Sensor Principles and Architectures , 2008 .

[42]  J. Sumerel,et al.  Piezoelectric ink jet processing of materials for medical and biological applications. , 2006, Biotechnology journal.

[43]  Arben Merkoçi,et al.  Configurations used in the design of screen-printed enzymatic biosensors. A review , 2000 .

[44]  G. G. Stokes "J." , 1890, The New Yale Book of Quotations.

[45]  M. L. Hair,et al.  Design criteria and future directions in ink-jet ink technology , 1989 .

[46]  Jinghua Yu,et al.  3D origami-based multifunction-integrated immunodevice: low-cost and multiplexed sandwich chemiluminescence immunoassay on microfluidic paper-based analytical device. , 2012, Lab on a chip.

[47]  R. Crooks,et al.  Three-dimensional paper microfluidic devices assembled using the principles of origami. , 2011, Journal of the American Chemical Society.

[48]  R. H. Firth,et al.  Colloids , 1914, Physics Subject Headings (PhySH).

[49]  G. Whitesides,et al.  Patterned paper as a platform for inexpensive, low-volume, portable bioassays. , 2007, Angewandte Chemie.

[50]  C. Megaridis,et al.  Inkjet patterned superhydrophobic paper for open-air surface microfluidic devices. , 2013, Lab on a chip.

[51]  I. McKelvie,et al.  A paper-based device for measurement of reactive phosphate in water. , 2012, Talanta.

[52]  Frances S Ligler,et al.  A microarray immunoassay for simultaneous detection of proteins and bacteria. , 2002, Analytical chemistry.

[53]  A Amirfazli,et al.  Producing a superhydrophobic paper and altering its repellency through ink-jet printing. , 2011, Lab on a chip.

[54]  Jooho Moon,et al.  Influence of fluid physical properties on ink-jet printability. , 2009, Langmuir : the ACS journal of surfaces and colloids.

[55]  I. Ursan,et al.  Three-dimensional drug printing: a structured review. , 2013, Journal of the American Pharmacists Association : JAPhA.

[56]  L. M. Davies,et al.  Development of a bioactive paper sensor for detection of neurotoxins using piezoelectric inkjet printing of sol-gel-derived bioinks. , 2009, Analytical chemistry.

[57]  Wolfgang Kowalsky,et al.  Large Area Electronics Using Printing Methods , 2005, Proceedings of the IEEE.

[58]  Osborne Reynolds,et al.  XXIX. An experimental investigation of the circumstances which determine whether the motion of water shall be direct or sinuous, and of the law of resistance in parallel channels , 1883, Philosophical Transactions of the Royal Society of London.

[59]  Heli Jantunen,et al.  Inkjet printing of electrically conductive patterns of carbon nanotubes. , 2006, Small.

[60]  Jun Ge,et al.  Ink-jet printing an optimal multi-enzyme system. , 2014, Chemical communications.

[61]  J. Bischof,et al.  Thermal Stability of Proteins , 2005, Annals of the New York Academy of Sciences.

[62]  R. Ruoff,et al.  All-organic vapor sensor using inkjet-printed reduced graphene oxide. , 2010, Angewandte Chemie.

[63]  Benjamin Wu,et al.  Customized biomimetic scaffolds created by indirect three-dimensional printing for tissue engineering , 2013, Biofabrication.

[64]  Brian Derby,et al.  Bioprinting: Inkjet printing proteins and hybrid cell-containing materials and structures , 2008 .

[65]  Wei Shen,et al.  Contact angle measurement and surface energetics of sized and unsized paper , 2000 .

[66]  Daniel Citterio,et al.  Inkjet-printed paper-based colorimetric sensor array for the discrimination of volatile primary amines. , 2013, Analytical chemistry.

[67]  W. Seitz,et al.  Transducer mechanisms for optical biosensors. Part 1: The chemistry of transduction. , 1989, Computer methods and programs in biomedicine.

[68]  Ulrich S. Schubert,et al.  Inkjet printing of proteins , 2009 .

[69]  Wei Shen,et al.  Biosurface engineering through ink jet printing. , 2010, Colloids and surfaces. B, Biointerfaces.

[70]  L. Rayleigh On The Instability Of Jets , 1878 .

[71]  A. Blayo,et al.  Impact of ink formulation on carbon nanotube network organization within inkjet printed conductive films , 2011 .

[72]  John D Brennan,et al.  Reagentless bidirectional lateral flow bioactive paper sensors for detection of pesticides in beverage and food samples. , 2009, Analytical chemistry.

[73]  Gary M Nishioka,et al.  Protein damage in drop-on-demand printers. , 2004, Journal of the American Chemical Society.

[74]  Kinam Park,et al.  A Glucose Sensor Fabricated by Piezoelectric Inkjet Printing of Conducting Polymers and Bienzymes , 2011, Analytical sciences : the international journal of the Japan Society for Analytical Chemistry.

[75]  Kj Clay,et al.  Direct legend printing (DLP) on printed circuit boards using piezoelectric inkjet technology , 2002 .

[76]  D. Citterio,et al.  Inkjet-printed microfluidic multianalyte chemical sensing paper. , 2008, Analytical chemistry.

[77]  Jooho Moon,et al.  Relationship between printability and rheological behavior of ink-jet conductive inks , 2013 .

[78]  Orawon Chailapakul,et al.  Novel, simple and low-cost alternative method for fabrication of paper-based microfluidics by wax dipping. , 2011, Talanta.

[79]  Shlomo Magdassi,et al.  The Chemistry of Inkjet Inks , 2009 .

[80]  Wei W. Yu,et al.  Inkjet-printed paper-based SERS dipsticks and swabs for trace chemical detection. , 2013, The Analyst.

[81]  B. Lin,et al.  Fabrication and characterization of paper-based microfluidics prepared in nitrocellulose membrane by wax printing. , 2010, Analytical chemistry.

[82]  Wei Shen,et al.  Paper-based device for rapid typing of secondary human blood groups , 2013, Analytical and Bioanalytical Chemistry.

[83]  Aaas News,et al.  Book Reviews , 1893, Buffalo Medical and Surgical Journal.

[84]  Wei Shen,et al.  Progress in patterned paper sizing for fabrication of paper-based microfluidic sensors , 2010 .

[85]  S. Schreiber,et al.  Printing proteins as microarrays for high-throughput function determination. , 2000, Science.

[86]  T L Dawson,et al.  Will ink jets ever replace screens for textile printing , 2008 .

[87]  Yong Woo Cho,et al.  Polymer inkjet printing: Construction of three-dimensional structures at micro-scale by repeated lamination , 2009 .

[88]  John Provost Recent Developments in Ink Jet Printing of Textiles with Reactive Dyes , 1998 .

[89]  G. Whitesides,et al.  Understanding wax printing: a simple micropatterning process for paper-based microfluidics. , 2009, Analytical chemistry.

[90]  Ratmir Derda,et al.  Flow-through synthesis on Teflon-patterned paper to produce peptide arrays for cell-based assays. , 2014, Angewandte Chemie.

[91]  J. E. Fromm,et al.  Numerical calculation of the fluid dynamics of drop-on-demand jets , 1984 .

[92]  N. Tien,et al.  Inkjet-printed microelectrodes on PDMS as biosensors for functionalized microfluidic systems. , 2015, Lab on a chip.

[93]  Yongsheng Chen,et al.  Graphene-based conducting inks for direct inkjet printing of flexible conductive patterns and their applications in electric circuits and chemical sensors , 2011 .

[94]  Bora Yoon,et al.  Inkjet-compatible single-component polydiacetylene precursors for thermochromic paper sensors. , 2013, ACS applied materials & interfaces.

[95]  Anjali Rajaratnam,et al.  A device architecture for three-dimensional, patterned paper immunoassays. , 2014, Lab on a chip.

[96]  Ning Yan,et al.  Bioactive Paper Through Inkjet Printing , 2010 .

[97]  Graham D. Martin,et al.  Links Between Ink Rheology, Drop-on-Demand Jet Formation, and Printability , 2009 .

[98]  David Robert Karsa Surfactants in Polymers, Coatings, Inks and Adhesives , 2003 .

[99]  Jisun Im,et al.  Photometer for monitoring the thickness of inkjet printed films for organic electronic and sensor applications. , 2010, The Review of scientific instruments.

[100]  Emanuel Carrilho,et al.  Paper microzone plates. , 2009, Analytical chemistry.

[101]  T. Kuriyama,et al.  An immobilized enzyme membrane fabrication method using an ink jet nozzle , 1989 .

[102]  J. W. Woods,et al.  Application of ink jet technology to a word processing output printer , 1977 .

[103]  R. Daniel,et al.  The upper limits of enzyme thermal stability , 1996 .

[104]  Jin-Woo Choi,et al.  Inkjet Printing of Carbon Nanotubes , 2013, Nanomaterials.

[105]  Enrico Sowade,et al.  Inkjet printing as a tool for the patterned deposition of octadecylsiloxane monolayers on silicon oxide surfaces. , 2013, Physical chemistry chemical physics : PCCP.

[106]  Daniel Citterio,et al.  An antibody-free microfluidic paper-based analytical device for the determination of tear fluid lactoferrin by fluorescence sensitization of Tb3+. , 2014, The Analyst.

[107]  Robert Pelton,et al.  Hydrophobic sol-gel channel patterning strategies for paper-based microfluidics. , 2014, Lab on a chip.

[108]  D. Sechi,et al.  Three-dimensional paper-based microfluidic device for assays of protein and glucose in urine. , 2013, Analytical chemistry.

[109]  Ericka Stricklin-Parker,et al.  Ann , 2005 .

[110]  Doyoung Byun,et al.  Design and Fabrication of Electrostatic Inkjet Head using Silicon Micromachining Technology , 2008 .

[111]  J. L. Delaney,et al.  Electrogenerated chemiluminescence detection in paper-based microfluidic sensors. , 2011, Analytical chemistry.

[112]  I. McKelvie,et al.  Evaluation and application of a paper-based device for the determination of reactive phosphate in soil solution. , 2014, Journal of environmental quality.

[113]  H. Le,et al.  Progress and Trends in Ink-jet Printing Technology , 1998, Journal of Imaging Science and Technology.

[114]  Daniel Bonn,et al.  Controlling droplet deposition with polymer additives , 2000, Nature.

[115]  Rafiq Ahmad,et al.  Wide linear-range detecting nonenzymatic glucose biosensor based on CuO nanoparticles inkjet-printed on electrodes. , 2013, Analytical chemistry.

[116]  Bongyoung Yoo,et al.  Construction of Micro-Patterned Polymer Structures by Piezoelectric Inkjet Printing , 2009 .

[117]  Vahid Mottaghitalab,et al.  Flexible biosensor using inkjet printing of silver nanoparticles , 2014 .

[118]  Bora Yoon,et al.  A litmus-type colorimetric and fluorometric volatile organic compound sensor based on inkjet-printed polydiacetylenes on paper substrates. , 2013, Macromolecular rapid communications.

[119]  B. Balu,et al.  Patterning of superhydrophobic paper to control the mobility of micro-liter drops for two-dimensional lab-on-paper applications. , 2009, Lab on a chip.

[120]  Robert Pelton,et al.  Morphology and Entrapped Enzyme Performance in Inkjet-Printed Sol–Gel Coatings on Paper , 2014 .

[121]  S. S. Sibbett,et al.  Multiplex lateral-flow test strips fabricated by two-dimensional shaping. , 2009, ACS applied materials & interfaces.

[122]  Robert Pelton,et al.  An inkjet-printed bioactive paper sensor that reports ATP through odour generation. , 2014, The Analyst.

[123]  A. Vermeer,et al.  The thermal stability of immunoglobulin: unfolding and aggregation of a multi-domain protein. , 2000, Biophysical journal.

[124]  Manos M. Tentzeris,et al.  Inkjet-printed paper-based RFID and nanotechnology-based ultrasensitive sensors: The “Green” ultimate solution for an ever improving life quality and safety? , 2010, 2010 IEEE Radio and Wireless Symposium (RWS).

[125]  Fengyu Li,et al.  Inkjet print microchannels based on a liquid template. , 2015, Lab on a chip.

[126]  Wei W. Yu,et al.  Inkjet printed surface enhanced Raman spectroscopy array on cellulose paper. , 2010, Analytical chemistry.

[127]  W. Marsden I and J , 2012 .

[128]  L. Setti,et al.  An amperometric glucose biosensor prototype fabricated by thermal inkjet printing. , 2005, Biosensors & bioelectronics.

[129]  Hui Chen,et al.  Microfluidic devices constructed by a marker pen on a silica gel plate for multiplex assays. , 2011, Analytical chemistry.

[130]  Gareth H. McKinley,et al.  Wolfgang von Ohnesorge , 2011 .

[131]  Vincent M. Rotello,et al.  Detection of Bacteria Using Inkjet-Printed Enzymatic Test Strips , 2014, ACS applied materials & interfaces.

[132]  S. Hossain,et al.  Multiplexed paper test strip for quantitative bacterial detection , 2012, Analytical and Bioanalytical Chemistry.

[133]  Eugenio Guglielmelli,et al.  Dispensing an enzyme-conjugated solution into an ELISA plate by adapting ink-jet printers. , 2008, Journal of biochemical and biophysical methods.

[134]  Paul Yager,et al.  Highly Sensitive Immunoassay Based on Controlled Rehydration of Patterned Reagents in a 2-Dimensional Paper Network , 2014, Analytical chemistry.

[135]  A. Roda,et al.  Protein microdeposition using a conventional ink-jet printer. , 2000, BioTechniques.

[136]  John A Rogers,et al.  Functional protein microarrays by electrohydrodynamic jet printing. , 2012, Analytical chemistry.

[137]  C. Piana,et al.  Thermal Inkjet Technology for the Microdeposition of Biological Molecules as a Viable Route for the Realization of Biosensors , 2004 .

[138]  Wei Shen,et al.  Paper-based blood typing device that reports patient's blood type "in writing". , 2012, Angewandte Chemie.

[139]  Andres W Martinez,et al.  Paper and toner three-dimensional fluidic devices: programming fluid flow to improve point-of-care diagnostics. , 2013, Lab on a chip.

[140]  Daniel Citterio,et al.  Inkjet-printed paperfluidic immuno-chemical sensing device , 2010, Analytical and bioanalytical chemistry.

[141]  Paul Yager,et al.  Two-dimensional paper network format that enables simple multistep assays for use in low-resource settings in the context of malaria antigen detection. , 2012, Analytical chemistry.

[142]  João F. Mano,et al.  Patterned superhydrophobic paper for microfluidic devices obtained by writing and printing , 2013, Cellulose.

[143]  Dimitra N. Stratis-Cullum,et al.  Investigation of microfabrication of biological sample arrays using piezoelectric and bubble-jet printing technologies , 2004 .

[144]  Shen Wei,et al.  Microfluidic paper-based analytical device for the determination of nitrite and nitrate. , 2014, Analytical chemistry.

[145]  John D. Meyer,et al.  Effects of Polymeric Additives on Thermal Ink Jets , 1999 .

[146]  Jeong-Woo Choi,et al.  Electrohydrodynamic (EHD) dispensing of nanoliter DNA droplets for microarrays. , 2006, Biosensors & bioelectronics.

[147]  G. Wallace,et al.  Wholly printed polypyrrole nanoparticle-based biosensors on flexible substrate. , 2014, Journal of materials chemistry. B.

[148]  D. Citterio,et al.  Inkjet printing: An integrated and green chemical approach to microfluidic paper-based analytical devices , 2013 .

[149]  John D Brennan,et al.  Printing silicone-based hydrophobic barriers on paper for microfluidic assays using low-cost ink jet printers. , 2014, The Analyst.

[150]  G. Whitesides,et al.  Simple telemedicine for developing regions: camera phones and paper-based microfluidic devices for real-time, off-site diagnosis. , 2008, Analytical chemistry.

[151]  Daniel Citterio,et al.  VOC-free inkjet patterning method for the fabrication of "paperfluidic" sensing devices , 2011 .

[152]  J. Olkkonen,et al.  Flexographically printed fluidic structures in paper. , 2010, Analytical chemistry.

[153]  G. Whitesides,et al.  Three-dimensional microfluidic devices fabricated in layered paper and tape , 2008, Proceedings of the National Academy of Sciences.

[154]  Joseph M Slocik,et al.  Multifunctional analytical platform on a paper strip: separation, preconcentration, and subattomolar detection. , 2013, Analytical chemistry.