CELL POPULATION KINETICS OF TRANSPLANTED AND METASTATIC LEWIS LUNG CARCINOMA

The growth rate of Lewis lung carcinoma, either as primary subcutaneous tumors or as spontaneous lung metastases, decreases with increasing age or mass. The length of the median cell cycle of the primary tumors increased from 17.6 hr at Day 5 to 25.9 hr at Day 21 with a concomitant increase in experimental doubling time from 2.5 to 9.6 days. The length of the median cell cycle of the metastatic lung nodules was 15.2 hr in the mice bearing 21‐day primary tumors. Two mathematical models were used to analyse the per cent labeled mitoses data and the results are given for comparison.

[1]  M L Mendelsohn,et al.  The growth fraction, a new concept applied to tumors. Abstr. , 1960 .

[2]  T. A. Watson,et al.  The rate of tumor growth in animals. , 1965 .

[3]  J. Cleaver.  The relationship between the duration of the S phase and the fraction of cells which incorporate 3-H-thymidine during exponential growth. , 1965, Experimental cell research.

[4]  J. C. Barrett.  A mathematical model of the mitotic cycle and its application to the interpretation of percentage labeled mitoses data. , 1966, Journal of the National Cancer Institute.

[5]  L. Simpson-Herren,et al.  The mitotic cycle of sarcoma 180. , 1968, Cancer research.

[6]  G. Steel,et al.  CELL LOSS FROM EXPERIMENTAL TUMOURS , 1968 .

[7]  W. Weiss.  Mitotic index of the primary tumor and its metastases in bronchogenic carcinoma. , 1969, The American review of respiratory disease.

[8]  T. R. Bryant.  Hydrolysis in Feulgen autoradiography. I. Loss of label from S-period nuclei and its subsequent association with non-S chromatin. , 1969, Experimental cell research.

[9]  A. K. Laird,et al.  Dynamics of growth in tumors and in normal organisms. , 1969, National Cancer Institute monograph.

[10]  S. R. Humphreys,et al.  Relationship of dose schedules to the effectiveness of adjuvant chemotherapy. , 1970, Cancer chemotherapy reports.

[11]  M. Mendelsohn,et al.  THE GROWTH KINETICS OF SOLID TUMORS: SUMMARY REPORT OF MEETING , 1970, Cell and tissue kinetics.

[12]  R. Sutherland,et al.  Differences in growth and morphology between the spontaneous C3H mammary carcinoma in the mouse and its syngeneic transplants , 1971, Cancer.

[13]  M Tubiana,et al.  Relation between the pathological nature and the growth rate of human tumors. , 1971, European journal of cancer.

[14]  G. Steel,et al.  THE TECHNIQUE OF LABELLED MITOSES: ANALYSIS BY AUTOMATIC CURVE‐FITTING , 1971, Cell and tissue kinetics.

[15]  F. Schabel,et al.  Success and failure in the treatment of solid tumors. 3. "Cure" of metastatic Lewis lung carcinoma with methyl-CCNU (NSC-95442) and surgery-chemotherapy. , 1972, Cancer chemotherapy reports.

[16]  W. Dewys.  A quantitative model for the study of the growth and treatment of a tumor and its metastases with correlation between proliferative state and sensitivity to cyclophosphamide. , 1972, Cancer research.

[17]  G H Weiss,et al.  Numerical inversion of Laplace transforms with application to percentage labeled mitoses experiments. , 1972, Computers and biomedical research, an international journal.

[18]  S. Salmon,et al.  Kinetics of tumor growth and regression in IgG multiple myeloma. , 1972, The Journal of clinical investigation.

[19]  P. Dombernowsky,et al.  Analysis of variations in the cell population kinetics with tumor age in the L1210 ascites tumor. , 1972, Cancer research.

[20]  W. Dewys.  Studies correlating the growth rate of a tumor and its metastases and providing evidence for tumor-related systemic growth-retarding factors. , 1972, Cancer research.