High-sensitivity high-throughput chip based biosensor array for multiplexed detection of heavy metals

Heavy metal ions released into the environment from industrial processes lead to various health hazards. We propose an on-chip label-free detection approach that allows high-sensitivity and high-throughput detection of heavy metals. The sensing device consists of 2-dimensional photonic crystal microcavities that are combined by multimode interferometer to form a sensor array. We experimentally demonstrate the detection of cadmium-chelate conjugate with concentration as low as 5 parts-per-billion (ppb).

[1]  Shon Schmidt,et al.  A silicon photonic biosensor using phase‐shifted Bragg gratings in slot waveguide , 2013, Journal of biophotonics.

[2]  Liang Tang,et al.  Label-free detection of cardiac troponin I with a photonic crystal biosensor. , 2014, Biosensors & bioelectronics.

[3]  D. Wylie,et al.  Metal Binding Properties of a Monoclonal Antibody Directed toward Metal-Chelate Complexes* , 1996, The Journal of Biological Chemistry.

[4]  A Densmore,et al.  Photonic wire biosensor microarray chip and instrumentation with application to serotyping of Escherichia coli isolates. , 2013, Optics express.

[5]  Ray T. Chen,et al.  Slow light enhanced sensitivity of resonance modes in photonic crystal biosensors. , 2013, Applied physics letters.

[6]  Ray T. Chen,et al.  CMOS Compatible, High Efficiency Subwavelength Grating Couplers for Silicon Integrated Photonics , 2012 .

[7]  Qian Wang,et al.  Improving the performance of silicon photonic rings, disks, and Bragg gratings for use in label-free biosensing , 2014, Optics & Photonics - NanoScience + Engineering.

[8]  Muzammil Iqbal,et al.  Label-Free Biosensor Arrays Based on Silicon Ring Resonators and High-Speed Optical Scanning Instrumentation , 2010, IEEE Journal of Selected Topics in Quantum Electronics.

[9]  Alp Artar,et al.  Integrated nanoplasmonic-nanofluidic biosensors with targeted delivery of analytes , 2010 .

[10]  Deyu Li,et al.  Biomolecule kinetics measurements in flow cell integrated porous silicon waveguides , 2012, Biomedical optics express.

[11]  Ray T. Chen,et al.  Wide dynamic range sensing in photonic crystal microcavity biosensors , 2014, 2014 Conference on Lasers and Electro-Optics (CLEO) - Laser Science to Photonic Applications.

[12]  Ray T. Chen,et al.  Analysis of ultra-high sensitivity configuration in chip-integrated photonic crystal microcavity bio-sensors. , 2014, Applied physics letters.

[13]  Harish Subbaraman,et al.  Microfluidic channels with ultralow-loss waveguide crossings for various chip-integrated photonic sensors. , 2015, Optics letters.

[14]  Feng Liang,et al.  Scalable photonic crystal chips for high sensitivity protein detection. , 2013, Optics express.

[15]  Michael R. Moore,et al.  Adverse Health Effects of Chronic Exposure to Low-Level Cadmium in Foodstuffs and Cigarette Smoke , 2004, Environmental health perspectives.