Notch Signaling in the Brain: More than Just a Developmental Story

[1]  T. Gridley.  Notch signaling during vascular development , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[2]  W. Chia,et al.  A requirement for Notch in the genesis of a subset of glial cells in the Drosophila embryonic central nervous system which arise through asymmetric divisions. , 2001, Development.

[3]  J. Campos-Ortega,et al.  An instructive function for Notch in promoting gliogenesis in the zebrafish retina. , 2001, Development.

[4]  Arturo Alvarez-Buylla,et al.  A unified hypothesis on the lineage of neural stem cells , 2001, Nature Reviews Neuroscience.

[5]  H. Fuchs,et al.  The Notch ligand Jagged1 is required for inner ear sensory development , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[6]  Justin P. Kumar,et al.  EGF Receptor and Notch Signaling Act Upstream of Eyeless/Pax6 to Control Eye Specification , 2001, Cell.

[7]  B. Hyman,et al.  Effect of PS1 deficiency and an APP gamma-secretase inhibitor on Notch1 signaling in primary mammalian neurons. , 2001, Brain research. Molecular brain research.

[8]  G. Fishell,et al.  Spatiotemporal selectivity of response to Notch1 signals in mammalian forebrain precursors. , 2001, Development.

[9]  J. Busciglio,et al.  Presenilin-1 Mutations Reduce Cytoskeletal Association, Deregulate Neurite Growth, and Potentiate Neuronal Dystrophy and Tau Phosphorylation , 2001, The Journal of Neuroscience.

[10]  Ross L. Cagan,et al.  Scabrous complexes with Notch to mediate boundary formation , 2001, Nature.

[11]  Tasuku Honjo,et al.  Notch1 and Notch3 Instructively Restrict bFGF-Responsive Multipotent Neural Progenitor Cells to an Astroglial Fate , 2001, Neuron.

[12]  G. Weinmaster,et al.  Ligand-induced signaling in the absence of furin processing of Notch1. , 2001, Developmental biology.

[13]  G. Struhl,et al.  Presenilin-mediated transmembrane cleavage is required for Notch signal transduction in Drosophila. , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[14]  Raphael Kopan,et al.  Notch signaling: from the outside in. , 2000, Developmental biology.

[15]  R. Kageyama,et al.  Hes1 is a negative regulator of inner ear hair cell differentiation. , 2000, Development.

[16]  T. Maynard,et al.  Cell interactions within nascent neural crest cell populations transiently promote death of neurogenic precursors. , 2000, Development.

[17]  T. Shirasawa,et al.  Notch‐1 activation by familial Alzheimer's disease (FAD)‐linked mutant forms of presenilin‐1 , 2000, Journal of neuroscience research.

[18]  J. Overbaugh,et al.  Evidence that an IRES within the Notch2 coding region can direct expression of a nuclear form of the protein. , 2000, Molecular cell.

[19]  U. Banerjee,et al.  Combinatorial Signaling in the Specification of Unique Cell Fates , 2000, Cell.

[20]  You-Qiang Song,et al.  Mutation of the conserved N‐terminal cysteine (Cys92) of human presenilin 1 causes increased Aβ42 secretion in mammalian cells but impaired Notch/lin‐I2 signalling in C. elegans , 2000, Neuroreport.

[21]  Ruedi Aebersold,et al.  Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and βAPP processing , 2000, Nature.

[22]  F. de Ribaupierre,et al.  Notch signaling regulates the pattern of auditory hair cell differentiation in mammals. , 2000, Development.

[23]  S. Röhrig,et al.  Presenilin is required for proper morphology and function of neurons in C. elegans , 2000, Nature.

[24]  B. Strooper,et al.  Total inactivation of γ–secretase activity in presenilin-deficient embryonic stem cells , 2000, Nature Cell Biology.

[25]  A. Bernstein,et al.  Presenilins are required for γ-secretase cleavage of β-APP and transmembrane cleavage of Notch-1 , 2000, Nature Cell Biology.

[26]  Y. Bessho,et al.  The bHLH gene Hes6, an inhibitor of Hes1, promotes neuronal differentiation. , 2000, Development.

[27]  T. Maynard,et al.  Fate determination of neural crest cells by NOTCH-mediated lateral inhibition and asymmetrical cell division during gangliogenesis. , 2000, Development.

[28]  T. Ohtsuka,et al.  Glial cell fate specification modulated by the bHLH gene Hes5 in mouse retina. , 2000, Development.

[29]  M. Handler,et al.  Presenilin-1 regulates neuronal differentiation during neurogenesis. , 2000, Development.

[30]  Y. Jan,et al.  Mouse numb is an essential gene involved in cortical neurogenesis. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[31]  David J Anderson,et al.  Transient Notch Activation Initiates an Irreversible Switch from Neurogenesis to Gliogenesis by Neural Crest Stem Cells , 2000, Cell.

[32]  D. Teplow,et al.  Separation of presenilin function in amyloid β-peptide generation and endoproteolysis of Notch , 2000, Neurobiology of Aging.

[33]  Eric M. Morrow,et al.  rax, Hes1, and notch1 Promote the Formation of Müller Glia by Postnatal Retinal Progenitor Cells , 2000, Neuron.

[34]  Gord Fishell,et al.  Radial Glial Identity Is Promoted by Notch1 Signaling in the Murine Forebrain , 2000, Neuron.

[35]  L. Saez,et al.  Notch Responds Differently to Delta and Wingless in CulturedDrosophila Cells* , 2000, The Journal of Biological Chemistry.

[36]  F. Chapon,et al.  The ectodomain of the Notch3 receptor accumulates within the cerebrovasculature of CADASIL patients. , 2000, The Journal of clinical investigation.

[37]  Bassem A. Hassan,et al.  atonal Regulates Neurite Arborization but Does Not Act as a Proneural Gene in the Drosophila Brain , 2000, Neuron.

[38]  Joseph L Goldstein,et al.  Regulated Intramembrane Proteolysis A Control Mechanism Conserved from Bacteria to Humans , 2000, Cell.

[39]  A Cumano,et al.  A novel proteolytic cleavage involved in Notch signaling: the role of the disintegrin-metalloprotease TACE. , 2000, Molecular cell.

[40]  A. Imperato,et al.  Hemisynaptic distribution patterns of presenilins and β‐APP isoforms in the rodent cerebellum and hippocampus , 2000, Synapse.

[41]  Raphael Kopan,et al.  A ligand-induced extracellular cleavage regulates gamma-secretase-like proteolytic activation of Notch1. , 2000, Molecular cell.

[42]  Anirvan Ghosh,et al.  Nuclear Notch1 signaling and the regulation of dendritic development , 2000, Nature Neuroscience.

[43]  P. Wong,et al.  Lack of requirement for Presenilin1 in Notch1 signaling , 1999, Current Biology.

[44]  J. Franklin,et al.  Autonomous and non-autonomous regulation of mammalian neurite development by Notch1 and Delta1 , 1999, Current Biology.

[45]  D. Selkoe,et al.  Cell Surface Presenilin-1 Participates in the γ-Secretase-like Proteolysis of Notch* , 1999, The Journal of Biological Chemistry.

[46]  A. Georgakopoulos,et al.  Presenilin-1 forms complexes with the cadherin/catenin cell-cell adhesion system and is recruited to intercellular and synaptic contacts. , 1999, Molecular cell.

[47]  C. Holt,et al.  p27Xic1, a Cdk Inhibitor, Promotes the Determination of Glial Cells in Xenopus Retina , 1999, Cell.

[48]  A. Bernstein,et al.  Mice lacking both presenilin genes exhibit early embryonic patterning defects. , 1999, Genes & development.

[49]  M. Mesulam.  Neuroplasticity Failure in Alzheimer's Disease Bridging the Gap between Plaques and Tangles , 1999, Neuron.

[50]  P. Rakic,et al.  Contact-dependent inhibition of cortical neurite growth mediated by notch signaling. , 1999, Science.

[51]  H. Vanderstichele,et al.  Presenilin 2 deficiency causes a mild pulmonary phenotype and no changes in amyloid precursor protein processing but enhances the embryonic lethal phenotype of presenilin 1 deficiency. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[52]  Y. A. Wang,et al.  Localization of Putative Stem Cells in Dental Epithelium and Their Association with Notch and Fgf Signaling , 1999, The Journal of cell biology.

[53]  D. Wettstein,et al.  Activation of Xenopus Genes Required for Lateral Inhibition and Neuronal Differentiation during Primary Neurogenesis , 1999, Molecular and Cellular Neuroscience.

[54]  G. Boulianne,et al.  Drosophila presenilin Is Required for Neuronal Differentiation and Affects Notch Subcellular Localization and Signaling , 1999, The Journal of Neuroscience.

[55]  U. Lendahl,et al.  The notch 3 intracellular domain represses notch 1-mediated activation through Hairy/Enhancer of split (HES) promoters. , 1999, Development.

[56]  H. Lipshitz,et al.  Distinct human NUMB isoforms regulate differentiation vs. proliferation in the neuronal lineage. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[57]  K D Irvine,et al.  Fringe, Notch, and making developmental boundaries. , 1999, Current opinion in genetics & development.

[58]  P. Sternberg,et al.  Competence and commitment of Caenorhabditis elegans vulval precursor cells. , 1999, Developmental biology.

[59]  A. Preiss,et al.  Overexpression of the m4 and mα genes of the E(spl)-Complex antagonizes Notch mediated lateral inhibition , 1999, Mechanisms of Development.

[60]  B. Strooper,et al.  Presenilin-1 deficiency leads to loss of Cajal–Retzius neurons and cortical dysplasia similar to human type 2 lissencephaly , 1999, Current Biology.

[61]  B. Hyman,et al.  Notch1 inhibits neurite outgrowth in postmitotic primary neurons , 1999, Neuroscience.

[62]  B T Hyman,et al.  The Alzheimer-related gene presenilin 1 facilitates notch 1 in primary mammalian neurons. , 1999, Brain research. Molecular brain research.

[63]  B. Yankner,et al.  Proteolytic release and nuclear translocation of Notch-1 are induced by presenilin-1 and impaired by pathogenic presenilin-1 mutations. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[64]  M. Frosch,et al.  Presenilin 1 Facilitates the Constitutive Turnover of β-Catenin: Differential Activity of Alzheimer’s Disease–Linked PS1 Mutants in the β-Catenin–Signaling Pathway , 1999, The Journal of Neuroscience.

[65]  M. H. Angelis,et al.  Expression of Delta1 and Serrate1 (Jagged1) in the mouse inner ear , 1999, Mechanisms of Development.

[66]  A. Martinez-Arias,et al.  An activity of Notch regulates JNK signalling and affects dorsal closure in Drosophila , 1999, Current Biology.

[67]  T. Maynard,et al.  NUMB Localizes in the Basal Cortex of Mitotic Avian Neuroepithelial Cells and Modulates Neuronal Differentiation by Binding to NOTCH-1 , 1999, Neuron.

[68]  M. Caudy,et al.  Regulation of hippocampal neuronal differentiation by the basic helix‐loop‐helix transcription factors HES‐1 and MASH‐1 , 1999, Journal of neuroscience research.

[69]  J. Campos-Ortega,et al.  her4, a zebrafish homologue of the Drosophila neurogenic gene E(spl), is a target of NOTCH signalling. , 1999, Development.

[70]  S. Artavanis-Tsakonas,et al.  Notch Signaling : Cell Fate Control and Signal Integration in Development , 1999 .

[71]  T. Ohtsuka,et al.  Hes1 and Hes5 as Notch effectors in mammalian neuronal differentiation , 1999, The EMBO journal.

[72]  Iva Greenwald,et al.  Presenilin is required for activity and nuclear access of Notch in Drosophila , 1999, Nature.

[73]  M. Fortini,et al.  Neurogenic phenotypes and altered Notch processing in Drosophila Presenilin mutants , 1999, Nature.

[74]  William J. Ray,et al.  A presenilin-1-dependent γ-secretase-like protease mediates release of Notch intracellular domain , 1999, Nature.

[75]  M. Basson,et al.  Reverse genetic analysis of Caenorhabditis elegans presenilins reveals redundant but unequal roles for sel-12 and hop-1 in Notch-pathway signaling. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[76]  G. Weinmaster,et al.  Notch signalling pathway mediates hair cell development in mammalian cochlea , 1999, Nature Genetics.

[77]  A. Chitnis.  Control of neurogenesis — lessons from frogs, fish and flies , 1999, Current Opinion in Neurobiology.

[78]  F. Guillemot,et al.  Mash1 regulates neurogenesis in the ventral telencephalon. , 1999, Development.

[79]  E. Wurmbach,et al.  The Enhancer of split complex of Drosophila melanogaster harbors three classes of Notch responsive genes , 1999, Mechanisms of Development.

[80]  P. Rakic,et al.  Processing of the notch ligand delta by the metalloprotease Kuzbanian. , 1999, Science.

[81]  S. Bray,et al.  Notch signalling in Drosophila: three ways to use a pathway. , 1998, Seminars in cell & developmental biology.

[82]  J. Lewis,et al.  Cell fate choices and the expression of Notch, Delta and Serrate homologues in the chick inner ear: parallels with Drosophila sense-organ development. , 1998, Development.

[83]  Kwang-Wook Choi,et al.  Fringe is essential for mirror symmetry and morphogenesis in the Drosophila eye , 1998, Nature.

[84]  T. L. Jacobsen,et al.  Cis-interactions between Delta and Notch modulate neurogenic signalling in Drosophila. , 1998, Development.

[85]  J. L. Dantzker,et al.  Properties of Ectopic Neurons Induced byXenopusNeurogenin1 Misexpression , 1998, Molecular and Cellular Neuroscience.

[86]  T. Kilpatrick,et al.  Regulation of neural stem cell differentiation in the forebrain , 1998, Immunology and cell biology.

[87]  I. Greenwald,et al.  Effects of SEL-12 presenilin on LIN-12 localization and function in Caenorhabditis elegans. , 1998, Development.

[88]  B. Hyman,et al.  Notch Is Expressed in Adult Brain, Is Coexpressed with Presenilin-1, and Is Altered in Alzheimer Disease , 1998, Journal of neuropathology and experimental neurology.

[89]  B. Barres,et al.  Notch Receptor Activation Inhibits Oligodendrocyte Differentiation , 1998, Neuron.

[90]  P. Bray-Ward,et al.  Human metalloprotease-disintegrin Kuzbanian regulates sympathoadrenal cell fate in development and neoplasia. , 1998, Human molecular genetics.

[91]  I. Greenwald,et al.  LIN-12/Notch signaling: lessons from worms and flies. , 1998, Genes & development.

[92]  Y. Jan,et al.  Delta and Serrate are redundant Notch ligands required for asymmetric cell divisions within the Drosophila sensory organ lineage. , 1998, Genes & development.

[93]  E. Giniger.  A Role for Abl in Notch Signaling , 1998, Neuron.

[94]  S. Artavanis-Tsakonas,et al.  Notch Inhibition of E47 Supports the Existence of a Novel Signaling Pathway , 1998, Molecular and Cellular Biology.

[95]  F. Guillemot,et al.  The bHLH Protein NEUROGENIN 2 Is a Determination Factor for Epibranchial Placode–Derived Sensory Neurons , 1998, Neuron.

[96]  David J. Anderson,et al.  neurogenin1 Is Essential for the Determination of Neuronal Precursors for Proximal Cranial Sensory Ganglia , 1998, Neuron.

[97]  J. Eisen,et al.  Regulation of neuronal specification in the zebrafish spinal cord by Delta function. , 1998, Development.

[98]  J. Lewis,et al.  Multiple delta genes and lateral inhibition in zebrafish primary neurogenesis. , 1998, Development.

[99]  G. Weinmaster,et al.  The Ins and Outs of Notch Signaling , 1997, Molecular and Cellular Neuroscience.

[100]  M. Caudy,et al.  Mediation of NGF signaling by post-translational inhibition of HES-1, a basic helix-loop-helix repressor of neuronal differentiation. , 1997, Genes & development.

[101]  I. Greenwald,et al.  HOP-1, a Caenorhabditis elegans presenilin, appears to be functionally redundant with SEL-12 presenilin and to facilitate LIN-12 and GLP-1 signaling. , 1997, Proceedings of the National Academy of Sciences of the United States of America.

[102]  S. Artavanis-Tsakonas,et al.  Intracellular Cleavage of Notch Leads to a Heterodimeric Receptor on the Plasma Membrane , 1997, Cell.

[103]  Wolfgang H. Fischer,et al.  Regulation of the ERBB-2 Promoter by RBPJκ and NOTCH* , 1997, The Journal of Biological Chemistry.

[104]  E. Kieff,et al.  Oncogenic Forms of NOTCH1 Lacking Either the Primary Binding Site for RBP-Jκ or Nuclear Localization Sequences Retain the Ability to Associate with RBP-Jκ and Activate Transcription* , 1997, The Journal of Biological Chemistry.

[105]  D. Wettstein,et al.  The Xenopus homolog of Drosophila Suppressor of Hairless mediates Notch signaling during primary neurogenesis. , 1997, Development.

[106]  W. Harris,et al.  Regulation of neuronal diversity in the Xenopus retina by Delta signalling , 1997, Nature.

[107]  P. Simpson,et al.  The LIN-12/Notch signaling pathway and its regulation. , 1997, Annual review of cell and developmental biology.

[108]  J. Weissenbach,et al.  Notch3 mutations in CADASIL, a hereditary adult-onset condition causing stroke and dementia , 1996, Nature.

[109]  David J. Anderson,et al.  Identification of neurogenin, a Vertebrate Neuronal Determination Gene , 1996, Cell.

[110]  C. Lobe,et al.  Transcripts of Grg4, a murine groucho-related gene, are detected in adjacent tissues to other murine neurogenic gene homologues during embryonic development , 1996, Mechanisms of Development.

[111]  Y. Jan,et al.  Control of Daughter Cell Fates during Asymmetric Division: Interaction of Numb and Notch , 1996, Neuron.

[112]  J. Boulter,et al.  Expression Patterns ofJagged, Delta1, Notch1, Notch2,andNotch3Genes Identify Ligand–Receptor Pairs That May Function in Neural Development , 1996, Molecular and Cellular Neuroscience.

[113]  Y. Jan,et al.  Asymmetric Localization of a Mammalian Numb Homolog during Mouse Cortical Neurogenesis , 1996, Neuron.

[114]  K. Nakahara,et al.  Mammalian hairy and Enhancer of Split Homolog 1 Regulates Differentiation of Retinal Neurons and Is Essential for Eye Morphogenesis , 1996, Neuron.

[115]  J. Lewis,et al.  A chick homologue of Serrate and its relationship with Notch and Delta homologues during central neurogenesis. , 1996, Developmental biology.

[116]  C. Cepko,et al.  Vertebrate retinal ganglion cells are selected from competent progenitors by the action of Notch. , 1995, Development.

[117]  S. Artavanis-Tsakonas,et al.  Involvement of Notch-1 in mammalian retinal neurogenesis: association of Notch-1 activity with both immature and terminally differentiated cells , 1995, Mechanisms of Development.

[118]  David Ish-Horowicz,et al.  Expression of a Delta homologue in prospective neurons in the chick , 1995, Nature.

[119]  M. Fortini,et al.  The suppressor of hairless protein participates in notch receptor signaling , 1994, Cell.

[120]  Raphael Kopan,et al.  An activated Notch suppresses neurogenesis and myogenesis but not gliogenesis in mammalian cells. , 1994, Development.

[121]  M. Koenderink,et al.  Postnatal maturation of the layer III pyramidal neurons in the human prefrontal cortex: a quantitative Golgi analysis , 1994, Brain Research.

[122]  K. Moriyoshi,et al.  Persistent expression of helix‐loop‐helix factor HES‐1 prevents mammalian neural differentiation in the central nervous system. , 1994, The EMBO journal.

[123]  W. Harris,et al.  Expression of an extracellular deletion of Xotch diverts cell fate in Xenopus embryos , 1993, Cell.

[124]  C. Cotman,et al.  Plasticity in Alzheimer's disease: Too much or not enough? , 1991, Neurobiology of Aging.

[125]  H. Uylings,et al.  The growth of non-pyramidal neurons in the visual cortex of the rat: A morphometric study , 1980, Brain Research.

[126]  Arnold B. Scheibel,et al.  Dendritic sprouting in Alzheimer's presenile dementia , 1978, Experimental Neurology.

[127]  G. Dunn.  Mutual contact inhibition of extension of chick sensory nerve fibres in vitro , 1971, The Journal of comparative neurology.