If you text them, they will come: using the HIV infant tracking system to improve early infant diagnosis quality and retention in Kenya

Objective:The objective of this study is to evaluate the impact of the HIV Infant Tracking System (HITSystem) for quality improvement of early infant diagnosis (EID) of HIV services. Design and Setting:This observational pilot study compared 12 months of historical preintervention EID outcomes at one urban and one peri-urban government hospital in Kenya to 12 months of intervention data to assess retention and time throughout the EID cascade of care. Participants:Mother–infant pairs enrolled in EID at participating hospitals before (n = 320) and during (n = 523) the HITSystem pilot were eligible to participate. Intervention:The HITSystem utilizes Internet-based coordination of the multistep PCR cycle, automated alerts to trigger prompt action from providers and laboratory technicians, and text messaging to notify mothers when results are ready or additional action is needed. Main outcome measures:The main outcome measures were retention throughout EID services, meeting time-sensitive targets and improving results turn-around time, and increasing early antiretroviral therapy (ART) initiation among HIV-infected infants. Results:The HITSystem was associated with an increase in the proportion of HIV-exposed infants retained in EID care at 9 months postnatal (45.1–93.0% urban; 43.2–94.1% peri-urban), a decrease in turn-around times between sample collection, PCR results and notification of mothers in both settings, and a significant increase in the proportion of HIV-infected infants started on antiretroviral therapy at each hospital(14 vs. 100% urban; 64 vs. 100% peri-urban). Conclusion:The HITSystem maximizes the use of easily accessible technology to improve the quality and efficiency of EID services in resource-limited settings.

[1]  J. Stockman Early Antiretroviral Therapy and Mortality among HIV-Infected Infants , 2010 .

[2]  Nigel Rollins,et al.  Mortality of infected and uninfected infants born to HIV-infected mothers in Africa: a pooled analysis , 2004, The Lancet.

[3]  W. Jack,et al.  Effects of a mobile phone short message service on antiretroviral treatment adherence in Kenya (WelTel Kenya1): a randomised trial , 2010, The Lancet.

[4]  James A McIntyre,et al.  Early antiretroviral therapy and mortality among HIV-infected infants. , 2008, The New England journal of medicine.

[5]  B. Walker,et al.  High frequency of rapid immunological progression in African infants infected in the era of perinatal HIV prophylaxis , 2007, AIDS.

[6]  M. Fowler,et al.  Infant human immunodeficiency virus diagnosis in resource-limited settings: issues, technologies, and country experiences. , 2007, American journal of obstetrics and gynecology.

[7]  D. Moodley,et al.  Factors Associated with Coverage of Cotrimoxazole Prophylaxis in HIV-Exposed Children in South Africa , 2013, PloS one.

[8]  Merrick Schaefer,et al.  Early infant diagnosis of HIV infection in Zambia through mobile phone texting of blood test results. , 2012, Bulletin of the World Health Organization.

[9]  P. Cherutich,et al.  Optimizing paediatric HIV care in Kenya: challenges in early infant diagnosis. , 2008, Bulletin of the World Health Organization.

[10]  B. Walker,et al.  Early virological suppression with three-class antiretroviral therapy in HIV-infected African infants , 2008, AIDS.

[11]  Robert W Snow,et al.  The effect of mobile phone text-message reminders on Kenyan health workers' adherence to malaria treatment guidelines: a cluster randomised trial , 2011, The Lancet.

[12]  A. Haines,et al.  The Effectiveness of Mobile-Health Technologies to Improve Health Care Service Delivery Processes: A Systematic Review and Meta-Analysis , 2013, PLoS medicine.

[13]  Rochelle P Walensky,et al.  Early infant HIV-1 diagnosis programs in resource-limited settings: opportunities for improved outcomes and more cost-effective interventions , 2011, BMC medicine.

[14]  S. Omer,et al.  Slower clearance of nevirapine resistant virus in infants failing extended nevirapine prophylaxis for prevention of mother-to-child HIV transmission. , 2011, AIDS research and human retroviruses.

[15]  J. Berkley,et al.  Dynamics and Constraints of Early Infant Diagnosis of HIV Infection in Rural Kenya , 2011, AIDS and Behavior.

[16]  Michelle Helena van Velthoven,et al.  Scope and effectiveness of mobile phone messaging for HIV/AIDS care: A systematic review , 2013, Psychology, health & medicine.

[17]  L Suzanne Suggs,et al.  SMS for disease control in developing countries: a systematic review of mobile health applications , 2012, Journal of telemedicine and telecare.

[18]  Matilu Mwau,et al.  Rapid identification of infants for antiretroviral therapy in a resource poor setting: the Kenya experience. , 2008, Journal of tropical pediatrics.