Renewal of oligodendrocyte lineage reverses dysmyelination and CNS neurodegeneration through corrected N-acetylaspartate metabolism

[1]  Hongda Li,et al.  The Oligodendrocyte Transcription Factor 2 OLIG2 regulates transcriptional repression during myelinogenesis in rodents , 2022, Nature communications.

[2]  Claire-Maelle Fovet,et al.  Long-term disease prevention with a gene therapy targeting oligodendrocytes in a mouse model of adrenomyeloneuropathy. , 2022, Human gene therapy.

[3]  A. Cardona,et al.  Fractalkine signaling regulates oligodendroglial cell genesis from SVZ precursor cells , 2021, Stem cell reports.

[4]  G. Gao,et al.  Canavan Disease as a Model for Gene Therapy-Mediated Myelin Repair , 2021, Frontiers in Cellular Neuroscience.

[5]  A. Brunetti,et al.  Unraveling Deep Gray Matter Atrophy and Iron and Myelin Changes in Multiple Sclerosis , 2021, American Journal of Neuroradiology.

[6]  W. Robberecht,et al.  AAV9-mediated gene delivery of MCT1 to oligodendrocytes does not provide a therapeutic benefit in a mouse model of ALS , 2021, Molecular therapy. Methods & clinical development.

[7]  Akshata A Almad,et al.  Glial cells in the driver seat of leukodystrophy pathogenesis , 2020, Neurobiology of Disease.

[8]  G. Caraveo,et al.  GAP-43 and BASP1 in Axon Regeneration: Implications for the Treatment of Neurodegenerative Diseases , 2020, Frontiers in Cell and Developmental Biology.

[9]  C. Betsholtz,et al.  Powerful Homeostatic Control of Oligodendroglial Lineage by PDGFRα in Adult Brain. , 2019, Cell reports.

[10]  C. Rae,et al.  Uncoupling N-acetylaspartate from brain pathology: implications for Canavan disease gene therapy , 2017, Acta Neuropathologica.

[11]  J. Moffett,et al.  Increasing N-acetylaspartate in the Brain during Postnatal Myelination Does Not Cause the CNS Pathologies of Canavan Disease , 2017, Front. Mol. Neurosci..

[12]  J. King,et al.  Redirecting N-acetylaspartate metabolism in the central nervous system normalizes myelination and rescues Canavan disease. , 2017, JCI insight.

[13]  D. Pleasure,et al.  Suppressing N-Acetyl-l-Aspartate Synthesis Prevents Loss of Neurons in a Murine Model of Canavan Leukodystrophy , 2017, The Journal of Neuroscience.

[14]  W. Richardson,et al.  Evolution of the CNS myelin gene regulatory program , 2016, Brain Research.

[15]  M. Schittmayer,et al.  N-acetylaspartate catabolism determines cytosolic acetyl-CoA levels and histone acetylation in brown adipocytes , 2016, Scientific Reports.

[16]  E. Chang,et al.  Purification and Characterization of Progenitor and Mature Human Astrocytes Reveals Transcriptional and Functional Differences with Mouse , 2016, Neuron.

[17]  S. Miller,et al.  Oligodendrocyte death results in immune-mediated CNS demyelination , 2015, Nature Neuroscience.

[18]  D. Hartmann,et al.  N-Acetylaspartate Synthase Deficiency Corrects the Myelin Phenotype in a Canavan Disease Mouse Model But Does Not Affect Survival Time , 2015, The Journal of Neuroscience.

[19]  G. Fishell,et al.  Inhibition of Gli1 mobilizes endogenous neural stem cells for remyelination , 2015, Nature.

[20]  C. Klämbt,et al.  Glial Glycolysis Is Essential for Neuronal Survival in Drosophila. , 2015, Cell metabolism.

[21]  T. Kilpatrick,et al.  Adult Neural Precursor Cells from the Subventricular Zone Contribute Significantly to Oligodendrocyte Regeneration and Remyelination , 2014, The Journal of Neuroscience.

[22]  David H. Miller,et al.  Pathogenesis of multiple sclerosis: insights from molecular and metabolic imaging , 2014, The Lancet Neurology.

[23]  J. Chan,et al.  Stage-Specific Deletion of Olig2 Conveys Opposing Functions on Differentiation and Maturation of Oligodendrocytes , 2013, The Journal of Neuroscience.

[24]  L. M. Wu,et al.  Olig2 Targets Chromatin Remodelers to Enhancers to Initiate Oligodendrocyte Differentiation , 2013, Cell.

[25]  D. Shera,et al.  Long-Term Follow-Up After Gene Therapy for Canavan Disease , 2012, Science Translational Medicine.

[26]  Pierre J. Magistretti,et al.  Oligodendroglia metabolically support axons and contribute to neurodegeneration , 2012, Nature.

[27]  Richard L. M. Faull,et al.  Adult Human Brain Neural Progenitor Cells (NPCs) and Fibroblast-Like Cells Have Similar Properties In Vitro but Only NPCs Differentiate into Neurons , 2012, PloS one.

[28]  Jens Frahm,et al.  Glycolytic oligodendrocytes maintain myelin and long-term axonal integrity , 2012, Nature.

[29]  A. Sartorius,et al.  Aspartoacylase-LacZ Knockin Mice: An Engineered Model of Canavan Disease , 2011, PloS one.

[30]  B. Lahn,et al.  Nestin Is Required for the Proper Self‐Renewal of Neural Stem Cells , 2010, Stem cells.

[31]  James M. Wilson,et al.  Molecular analysis of vector genome structures after liver transduction by conventional and self-complementary adeno-associated viral serotype vectors in murine and nonhuman primate models. , 2010, Human gene therapy.

[32]  K. Jin,et al.  Transgenic ablation of doublecortin-expressing cells suppresses adult neurogenesis and worsens stroke outcome in mice , 2010, Proceedings of the National Academy of Sciences.

[33]  R. Matalon,et al.  Lack of aspartoacylase activity disrupts survival and differentiation of neural progenitors and oligodendrocytes in a mouse model of Canavan disease , 2009, Journal of neuroscience research.

[34]  S. Kawamoto,et al.  Identification of Neuronal Nuclei (NeuN) as Fox-3, a New Member of the Fox-1 Gene Family of Splicing Factors* , 2009, The Journal of Biological Chemistry.

[35]  B. Barres,et al.  Nur7 Is a Nonsense Mutation in the Mouse Aspartoacylase Gene That Causes Spongy Degeneration of the CNS , 2008, The Journal of Neuroscience.

[36]  O. Al-Dirbashi,et al.  Stable isotope dilution analysis of N-acetylaspartic acid in urine by liquid chromatography electrospray ionization tandem mass spectrometry. , 2007, Biomedical chromatography : BMC.

[37]  V. Balasubramaniyan,et al.  Olig2 Overexpression Induces the In Vitro Differentiation of Neural Stem Cells into Mature Oligodendrocytes , 2006, Stem cells.

[38]  Chao Zhao,et al.  Myelin Impairs CNS Remyelination by Inhibiting Oligodendrocyte Precursor Cell Differentiation , 2006, The Journal of Neuroscience.

[39]  T. Adam,et al.  Determination of creatinine in urine by tandem mass spectrometry. , 2004, Clinica chimica acta; international journal of clinical chemistry.

[40]  K. Nave,et al.  Disruption of Cnp1 uncouples oligodendroglial functions in axonal support and myelination , 2003, Nature Genetics.

[41]  Robin J. M. Franklin,et al.  Why does remyelination fail in multiple sclerosis? , 2002, Nature Reviews Neuroscience.

[42]  M. Baslow.  Hypothesis: Molecular water pumps and the aetiology of Canavan disease: A case of the sorcerer's apprentice , 1999, Journal of Inherited Metabolic Disease.

[43]  R. Schmidt-Kastner,et al.  Nestin expression in reactive astrocytes following focal cerebral ischemia in rats , 1997, Brain Research.

[44]  U. Lendahl,et al.  Nestin mRNA expression correlates with the central nervous system progenitor cell state in many, but not all, regions of developing central nervous system. , 1995, Brain research. Developmental brain research.

[45]  M. Adachi,et al.  Spongy degeneration of the central nervous system (van Bogaert and Bertrand type; Canavan's disease). A review. , 1973, Human pathology.

[46]  R. Clements,et al.  The neuronal metabolite NAA regulates histone H3 methylation in oligodendrocytes and myelin lipid composition , 2016, Experimental Brain Research.

[47]  M. Wegner,et al.  Gain of Olig2 function in oligodendrocyte progenitors promotes remyelination. , 2015, Brain : a journal of neurology.

[48]  S. Payne,et al.  Lysophosphatidic Acid can Support the Formation of Membranous Structures and an Increase in MBP mRNA Levels in Differentiating Oligodendrocytes , 2008, Neurochemical Research.

[49]  T. Umemura,et al.  Spongy Degeneration of the Central Nervous System in a Calf , 1988 .