The oxidative metabolism of Trypanosoma lewisi in a phosphate-saline medium.

different types of antibodies are formed by the rat in response to infection with T. lewisi. One type of antibody appears early in the infection and inhibits the reproduction of the trypanosomes but allows them to develop into adult individuals. The second type of antibody appears at intervals later in thfe infection and kills varying proportions of the trypanosomes until all are killed and the infection terminated. In order better to understand the mechanism of action of the reproduction-inhibiting and the killing antibodies formed by the rat in response to infection with T. lewisi, the metabolism of these trypanosomes has been studied with particular attention to the possible effects of antibodies upon metabolic processes. The only detailed metabolic studies on these trypanosomes are by Reiner, Smythe, and Pedlow2 and by