Curcumin ameliorates hippocampal neuron damage induced by human immunodeficiency virus-1

Our previous studies have shown that infection with the gp120 V3 loop can cause human immunodeficiency virus-1 associated neurocognitive disorders. Curcumin has been shown to improve these effects to some degree, but the precise mechanisms remain unknown. The present study analyzed the neuroprotective effect and mechanism of curcumin in relation to hippocampal neurons. Results showed that 1 nmol/L gp120 V3 loop suppressed the growth of synapses. After administration of 1 μmol/L curcumin, synaptic growth improved. Curcumin is neuroprotective against gp120 V3 loop-induced neuronal damage by inhibiting the activation of L-type calcium currents, relieving intracellular Ca2+ overload, promoting Bcl-2 expression, and inhibiting Bax activation. The effect of curcumin was identical to nimodipine, suggesting that curcumin has the same neuroprotective effects against gp120 V3 loop-induced neuronal damage.

[1]  Anita Lüthi,et al.  Synaptic Plasticity at Intrathalamic Connections via CaV3.3 T-type Ca2+ Channels and GluN2B-Containing NMDA Receptors , 2013, The Journal of Neuroscience.

[2]  R. Heidelberger,et al.  Regulation of presynaptic calcium in a mammalian synaptic terminal. , 2012, Journal of neurophysiology.

[3]  Anil Kumar,et al.  HIV-1 gp120 and drugs of abuse: interactions in the central nervous system. , 2012, Current HIV research.

[4]  R. Gregg,et al.  Use of the anti-inflammatory cytokine interleukin-11 to reverse HIV-1gp120 repression of a natural killer cell line. , 2012, Cellular Immunology.

[5]  Yan-yan Xing,et al.  Protective effects of curcumin against human immunodeficiency virus 1 gp120 V3 loop-induced neuronal injury in rats , 2012, Neural regeneration research.

[6]  M. A. Abad,et al.  NP1 Regulates Neuronal Activity-Dependent Accumulation of BAX in Mitochondria and Mitochondrial Dynamics , 2012, The Journal of Neuroscience.

[7]  C. Borel,et al.  Neuroprotective effect of curcumin in an experimental rat model of subarachnoid hemorrhage. , 2011, Anesthesiology.

[8]  H. Xiong,et al.  HIV-1gp120 Induces Neuronal Apoptosis through Enhancement of 4-Aminopyridine-Senstive Outward K+ Currents , 2011, PloS one.

[9]  Lie-Chwen Lin,et al.  Curcumin and its nano-formulation: the kinetics of tissue distribution and blood-brain barrier penetration. , 2011, International journal of pharmaceutics.

[10]  W. Chiu,et al.  Curcumin enhances neuronal survival in N-methyl-d-aspartic acid toxicity by inducing RANTES expression in astrocytes via PI-3K and MAPK signaling pathways , 2011, Progress in Neuro-Psychopharmacology and Biological Psychiatry.

[11]  T. Timmusk,et al.  Identification of cis-Elements and Transcription Factors Regulating Neuronal Activity-Dependent Transcription of Human BDNF Gene , 2011, The Journal of Neuroscience.

[12]  L. Caixeta,et al.  HIV-associated dementia in older adults: clinical and tomographic aspects , 2011, International Psychogeriatrics.

[13]  A. Muñoz,et al.  [HIV-1 neuropathogenesis: therapeutic strategies against neuronal loss induced by gp120/Tat glycoprotein in the central nervous system]. , 2011, Revista de neurologia.

[14]  S. Perry,et al.  Human Immunodeficiency Virus-1 Tat Activates Calpain Proteases via the Ryanodine Receptor to Enhance Surface Dopamine Transporter Levels and Increase Transporter-Specific Uptake and Vmax , 2010, The Journal of Neuroscience.

[15]  A. Haghparast,et al.  Neuroprotective effects of the polyphenolic antioxidant agent, Curcumin, against homocysteine-induced cognitive impairment and oxidative stress in the rat , 2010, Pharmacology Biochemistry and Behavior.

[16]  J. Berman,et al.  Immunopathology and Infectious Diseases Mechanisms of HIV-tat-Induced Phosphorylation of N-Methyl-D-Aspartate Receptor Subunit 2 A in Human Primary Neurons Implications for NeuroAIDS Pathogenesis , 2010 .

[17]  S. Lipton,et al.  Memantine for AIDS Dementia Complex: Open-Label Report of ACTG 301 , 2010, HIV clinical trials.

[18]  T. Milne,et al.  Real-time PCR focused-gene array profiling of gingival and periodontal ligament fibroblasts. , 2010, Methods in molecular biology.

[19]  E. Major,et al.  Differences in NMDA Receptor Expression During Human Development Determine the Response of Neurons to HIV-Tat-mediated Neurotoxicity , 2010, Neurotoxicity Research.

[20]  A. Fagan,et al.  CSF biomarkers of Alzheimer disease in HIV-associated neurologic disease , 2009, Neurology.

[21]  H. Xiong,et al.  Curcumin improves spatial memory impairment induced by human immunodeficiency virus type 1 glycoprotein 120 V3 loop peptide in rats. , 2009, Life sciences.

[22]  S. Smaili,et al.  Bcl-xL inhibits Bax-induced alterations in mitochondrial respiration and calcium release , 2008, Neuroscience Letters.

[23]  N. Sacktor,et al.  Developing neuroprotective strategies for treatment of HIV-associated neurocognitive dysfunction. , 2008, Future HIV therapy.

[24]  E. V. Bockstaele,et al.  Protecting neurons from HIV-1 gp120-induced oxidant stress using both localized intracerebral and generalized intraventricular administration of antioxidant enzymes delivered by SV40-derived vectors , 2007, Gene Therapy.

[25]  B. Aggarwal,et al.  Role of pro-oxidants and antioxidants in the anti-inflammatory and apoptotic effects of curcumin (diferuloylmethane). , 2007, Free radical biology & medicine.

[26]  S. Shishodia,et al.  Modulation of transcription factors by curcumin. , 2007, Advances in experimental medicine and biology.

[27]  A. Olson,et al.  Active site binding modes of curcumin in HIV-1 protease and integrase. , 2005, Bioorganic & medicinal chemistry letters.

[28]  Y. Pommier,et al.  Design, synthesis and biological evaluation of heteroaryl diketohexenoic and diketobutanoic acids as HIV-1 integrase inhibitors endowed with antiretroviral activity. , 2005, Farmaco.

[29]  M. Kaul,et al.  HIV-1 infection and AIDS: consequences for the central nervous system , 2005, Cell Death and Differentiation.

[30]  Francisco González-Scarano,et al.  The neuropathogenesis of AIDS , 2005, Nature Reviews Immunology.

[31]  J. McArthur.  HIV dementia: an evolving disease , 2004, Journal of Neuroimmunology.

[32]  R. Puvanakrishnan,et al.  Curcumin modulates free radical quenching in myocardial ischaemia in rats. , 2004, The international journal of biochemistry & cell biology.

[33]  T. Creazzo,et al.  Calcium buffering and excitation-contraction coupling in developing avian myocardium. , 2004, Biophysical journal.

[34]  D. Purcell,et al.  Astrocyte infection by HIV-1: mechanisms of restricted virus replication, and role in the pathogenesis of HIV-1-associated dementia. , 2003, Current HIV research.

[35]  P. Riederer,et al.  The pathogenesis of HIV-induced dementia , 2002, Mechanisms of Ageing and Development.

[36]  J. Ávila,et al.  Phosphorylation of microtubule-associated protein 2 (MAP2) and its relevance for the regulation of the neuronal cytoskeleton function , 2000, Progress in Neurobiology.

[37]  H. Xiong,et al.  HIV-1 infected mononuclear phagocyte secretory products affect neuronal physiology leading to cellular demise: relevance for HIV-1-associated dementia. , 2000, Journal of neurovirology.