Perfusion‐based event‐related functional MRI

Perfusion‐based event‐related functional MRI was performed by measuring flow‐sensitive alternating inversion recovery (FAIR) signal changes during repeated single‐trial, short visual stimulation (250 msec). In the visual cortex activation area, the blood flow increases immediately after the stimulus, reaches the maximum 4 sec later with a perfusion‐sensitized signal change of 16.1 ± 2.6 %, and then decreases to baseline approximately 11 sec after the stimuli. As it is a more direct reflection of the hemodynamic response, perfusion‐based event‐related functional MRI techniques may be more useful for human cognitive function studies, compared with blood oxygenation level–dependent (BOLD)‐based event‐related functional MRI techniques. Magn Reson Med 42:1011–1013, 1999. © 1999 Wiley‐Liss, Inc.

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