ADAPTIVE SEGMENTATION OF MEDICAL MR IMAGES BASED ON BIAS CORRECTION

A two-phase model is introduced to extract clinically useful information from medical MR images. In the preprocessing phase, a refined bias correction method is adopted to reduce the influence of intensity inhomogeneity by removing the bias field, which paves the way for improving the subsequent segmentation accuracy. During image segmentation process, a novel adaptive level set technique is designed to capture the boundary of desired region. By virtue of adaptive driving term, the external force automatically changes its propagating direction when evolving curve goes through object boundary, which effectively prevents the final results deviating from correct position. Moreover, insensitivity to initial contour also enables its automatic applications. Experiments on synthetic and real MR images demonstrate the feasibility and robustness of the proposed method.

[1]  Chunming Li,et al.  Minimization of Region-Scalable Fitting Energy for Image Segmentation , 2008, IEEE Transactions on Image Processing.

[2]  Nikos Paragios,et al.  Gradient vector flow fast geometric active contours , 2004, IEEE Transactions on Pattern Analysis and Machine Intelligence.

[3]  Aly A. Farag,et al.  A modified fuzzy c-means algorithm for bias field estimation and segmentation of MRI data , 2002, IEEE Transactions on Medical Imaging.

[4]  Patrick Clarysse,et al.  Correction of bias field in MR images using singularity function analysis , 2005, IEEE Transactions on Medical Imaging.

[5]  Richard A. Robb,et al.  Optimized homomorphic unsharp masking for MR grayscale inhomogeneity correction , 1998, IEEE Transactions on Medical Imaging.

[6]  Jerry L. Prince,et al.  Generalized gradient vector flow external forces for active contours , 1998, Signal Process..

[7]  Guillermo Sapiro,et al.  Geodesic Active Contours , 1995, International Journal of Computer Vision.

[8]  Bostjan Likar,et al.  A Review of Methods for Correction of Intensity Inhomogeneity in MRI , 2007, IEEE Transactions on Medical Imaging.

[9]  Stephen M. Smith,et al.  Segmentation of brain MR images through a hidden Markov random field model and the expectation-maximization algorithm , 2001, IEEE Transactions on Medical Imaging.

[10]  Shang-Hong Lai,et al.  A new variational shape-from-orientation approach to correcting intensity inhomogeneities in magnetic resonance images , 1999, Medical Image Anal..

[11]  Hugues Benoit-Cattin,et al.  Intensity non-uniformity correction in MRI: Existing methods and their validation , 2006, Medical Image Anal..

[12]  Jerry L. Prince,et al.  Adaptive fuzzy segmentation of magnetic resonance images , 1999, IEEE Transactions on Medical Imaging.

[13]  Xiao-Feng Wang,et al.  A Level Set Based Segmentation Method for Images with Intensity Inhomogeneity , 2009, ICIC.

[14]  Y M Zhu,et al.  A method of radio-frequency inhomogeneity correction for brain tissue segmentation in MRI. , 2001, Computerized medical imaging and graphics : the official journal of the Computerized Medical Imaging Society.

[15]  Kaleem Siddiqi,et al.  Area and length minimizing flows for shape segmentation , 1998, IEEE Trans. Image Process..