The ongoing coronavirus pandemic, is affecting the lives of millions of people, while changing our society by establishing new norms for social life, business, and traveling The digital health domain has already tried to respond to the pandemic challenges, by the rapid development and release of mobile apps aiming to “flatten the curve” of the increasing number of COVID-19 cases In this paper, starting from our own developed app to support citizens staying “Safe in COVID-19”, we present our vision on how semantics and data management could highly contribute, along with personal health apps, to the secondary usage of available data in order to support effective disease management, prediction and increase the collective knowledge on the disease Copyright © 2020 for this paper by its authors Use permitted under Creative Commons License Attribution 4 0 International (CC BY 4 0)