Development of magneto-plasmonic nanoparticles for multimodal image-guided therapy to the brain.

Magneto-plasmonic nanoparticles are one of the emerging multi-functional materials in the field of nanomedicine. Their potential for targeting and multi-modal imaging is highly attractive. In this study, magnetic core/gold shell (MNP@Au) magneto-plasmonic nanoparticles were synthesized by citrate reduction of Au ions on magnetic nanoparticle seeds. Hydrodynamic size and optical properties of magneto-plasmonic nanoparticles synthesized with the variation of Au ions and reducing agent concentrations were evaluated. The synthesized magneto-plasmonic nanoparticles exhibited superparamagnetic properties, and their magnetic properties contributed to the concentration-dependent contrast in magnetic resonance imaging (MRI). The imaging contrast from the gold shell part of the magneto-plasmonic nanoparticles was also confirmed by X-ray computed tomography (CT). The transmigration study of the magneto-plasmonic nanoparticles using an in vitro blood-brain barrier (BBB) model proved enhanced transmigration efficiency without disrupting the integrity of the BBB, and showed potential to be used for brain diseases and neurological disorders.

[1]  A. Kaushik,et al.  Getting into the brain: Potential of nanotechnology in the management of NeuroAIDS. , 2016, Advanced drug delivery reviews.

[2]  Daniel N. Sosa,et al.  Current status of non-viral gene therapy for CNS disorders , 2016, Expert opinion on drug delivery.

[3]  M. Nair,et al.  Magnetically guided central nervous system delivery and toxicity evaluation of magneto-electric nanocarriers , 2016, Scientific Reports.

[4]  M. Nair,et al.  Microglia-derived HIV Nef+ exosome impairment of the blood–brain barrier is treatable by nanomedicine-based delivery of Nef peptides , 2015, Journal of NeuroVirology.

[5]  Chien-Wen Chang,et al.  Redox-Sensitive Polymer/SPIO Nanocomplexes for Efficient Magnetofection and MR Imaging of Human Cancer Cells. , 2015, Langmuir : the ACS journal of surfaces and colloids.

[6]  V. Polshettiwar,et al.  Facile and Sustainable Synthesis of Shaped Iron Oxide Nanoparticles: Effect of Iron Precursor Salts on the Shapes of Iron Oxides , 2015, Scientific Reports.

[7]  V. Chekhonin,et al.  VEGF-targeted magnetic nanoparticles for MRI visualization of brain tumor. , 2015, Nanomedicine : nanotechnology, biology, and medicine.

[8]  Yali Cui,et al.  Controllable synthesis and characterization of Fe3O4/Au composite nanoparticles , 2015 .

[9]  Shujuan Fan,et al.  Curcumin-conjugated magnetic nanoparticles for detecting amyloid plaques in Alzheimer's disease mice using magnetic resonance imaging (MRI). , 2015, Biomaterials.

[10]  M. Nair,et al.  Sustained-release nanoART formulation for the treatment of neuroAIDS , 2015, International journal of nanomedicine.

[11]  M. Nair,et al.  The potential of magneto-electric nanocarriers for drug delivery , 2014, Expert opinion on drug delivery.

[12]  M. Toyoda,et al.  Pleiotropic functions of magnetic nanoparticles for ex vivo gene transfer. , 2014, Nanomedicine : nanotechnology, biology, and medicine.

[13]  Xiaolong Liang,et al.  Prussian blue coated gold nanoparticles for simultaneous photoacoustic/CT bimodal imaging and photothermal ablation of cancer. , 2014, Biomaterials.

[14]  V. Sagar,et al.  Enhanced blood–brain barrier transmigration using a novel transferrin embedded fluorescent magneto-liposome nanoformulation , 2014, Nanotechnology.

[15]  S. Choi,et al.  Nano‐Sized CT Contrast Agents , 2013, Advanced materials.

[16]  A. Tomitaka,et al.  Heat dissipation and magnetic properties of surface-coated Fe3O4 nanoparticles for biomedical applications , 2012 .

[17]  H. Car,et al.  Nanoparticles as drug delivery systems , 2012, Pharmacological reports : PR.

[18]  T. Rojo,et al.  Functionalized Fe3O4@Au superparamagnetic nanoparticles: in vitro bioactivity , 2012, Nanotechnology.

[19]  Svetlana Gelperina,et al.  Transport of drugs across the blood-brain barrier by nanoparticles. , 2012, Journal of controlled release : official journal of the Controlled Release Society.

[20]  Hiroyuki Saimoto,et al.  Nanofibrillation of Dry Chitin Powder by Star Burst System , 2012 .

[21]  Lihong V. Wang,et al.  Photoacoustic Tomography: In Vivo Imaging from Organelles to Organs , 2012, Science.

[22]  Weijun Peng,et al.  Multifunctional nanoprobes for upconversion fluorescence, MR and CT trimodal imaging. , 2012, Biomaterials.

[23]  Zhiqiang Gao,et al.  Biocompatibility of Fe3O4@Au composite magnetic nanoparticles in vitro and in vivo , 2011, International Journal of Nanomedicine.

[24]  S. Shen,et al.  Facile synthesis of superparamagnetic Fe3O4@Au nanoparticles for photothermal destruction of cancer cells. , 2011, Chemical communications.

[25]  Ralph Weissleder,et al.  Dextran-coated iron oxide nanoparticles: a versatile platform for targeted molecular imaging, molecular diagnostics, and therapy. , 2011, Accounts of chemical research.

[26]  Yun Sun,et al.  Targeted dual-contrast T1- and T2-weighted magnetic resonance imaging of tumors using multifunctional gadolinium-labeled superparamagnetic iron oxide nanoparticles. , 2011, Biomaterials.

[27]  K. Yong,et al.  A Review on Functionalized Gold Nanoparticles for Biosensing Applications , 2011 .

[28]  I. Wilhelm,et al.  In vitro models of the blood-brain barrier. , 2011, Acta neurobiologiae experimentalis.

[29]  Nastassja A. Lewinski,et al.  A new era for cancer treatment: gold-nanoparticle-mediated thermal therapies. , 2011, Small.

[30]  Gang Bao,et al.  Coating optimization of superparamagnetic iron oxide nanoparticles for high T2 relaxivity. , 2010, Nano letters.

[31]  C. Kumar,et al.  Influence of Gold Nanoshell on Hyperthermia of Super Paramagnetic Iron Oxide Nanoparticles (SPIONs). , 2010, The journal of physical chemistry. C, Nanomaterials and interfaces.

[32]  Shunqing Xu,et al.  Gold nanoparticle-based biosensors , 2010 .

[33]  Jutaek Nam,et al.  pH-Induced aggregation of gold nanoparticles for photothermal cancer therapy. , 2009, Journal of the American Chemical Society.

[34]  Sang Jun Sim,et al.  Application of citrate-stabilized gold-coated ferric oxide composite nanoparticles for biological separations , 2008 .

[35]  Chenjie Xu,et al.  Size and Concentration Effect of Gold Nanoparticles on X-ray Attenuation As Measured on Computed Tomography. , 2008, Chemistry of materials : a publication of the American Chemical Society.

[36]  B. Zlokovic.  The Blood-Brain Barrier in Health and Chronic Neurodegenerative Disorders , 2008, Neuron.

[37]  Jun Li,et al.  Size control of gold nanocrystals in citrate reduction: the third role of citrate. , 2007, Journal of the American Chemical Society.

[38]  T. Terasaki,et al.  Contribution of Carrier-Mediated Transport Systems to the Blood–Brain Barrier as a Supporting and Protecting Interface for the Brain; Importance for CNS Drug Discovery and Development , 2007, Pharmaceutical Research.

[39]  Zhichuan J. Xu,et al.  Magnetic core/shell Fe3O4/Au and Fe3O4/Au/Ag nanoparticles with tunable plasmonic properties. , 2007, Journal of the American Chemical Society.

[40]  J. T. Mayo,et al.  Low-Field Magnetic Separation of Monodisperse Fe3O4 Nanocrystals , 2006, Science.

[41]  M. El-Sayed,et al.  Why gold nanoparticles are more precious than pretty gold: noble metal surface plasmon resonance and its enhancement of the radiative and nonradiative properties of nanocrystals of different shapes. , 2006, Chemical Society reviews.

[42]  Tarasankar Pal,et al.  Magnetite nanoparticles with tunable gold or silver shell. , 2005, Journal of colloid and interface science.

[43]  Ajay Kumar Gupta,et al.  Synthesis and surface engineering of iron oxide nanoparticles for biomedical applications. , 2005, Biomaterials.

[44]  M. Nedergaard,et al.  The blood–brain barrier: an overview Structure, regulation, and clinical implications , 2004, Neurobiology of Disease.

[45]  Mary Elizabeth Williams,et al.  Synthesis of Fe Oxide Core/Au Shell Nanoparticles by Iterative Hydroxylamine Seeding , 2004 .

[46]  R. E. Rosensweig,et al.  Heating magnetic fluid with alternating magnetic field , 2002 .

[47]  Everett E. Carpenter,et al.  Gold-coated iron (Fe@Au) nanoparticles: Synthesis, characterization, and magnetic field-induced self-assembly , 2001 .

[48]  M. Natan,et al.  Seeding of Colloidal Au Nanoparticle Solutions. 2. Improved Control of Particle Size and Shape , 2000 .

[49]  E. Matijević,et al.  Tailoring the particle size of monodispersed colloidal gold , 1999 .

[50]  Michael J. Natan,et al.  Hydroxylamine Seeding of Colloidal Au Nanoparticles in Solution and on Surfaces , 1998 .

[51]  A. Berkowitz,et al.  Influence of Crystallite Size on the Magnetic Properties of Acicular γ‐Fe2O3 Particles , 1968 .

[52]  Y. Tabata,et al.  Preparation of biodegradable iron oxide nanoparticles with gelatin for magnetic resonance imaging , 2014 .

[53]  W. Zhong,et al.  Reducible polyamidoamine-magnetic iron oxide self-assembled nanoparticles for doxorubicin delivery. , 2014, Biomaterials.

[54]  U. Mony,et al.  Biocompatible magnetite/gold nanohybrid contrast agents via green chemistry for MRI and CT bioimaging. , 2012, ACS applied materials & interfaces.

[55]  A. Tomitaka,et al.  Magnetic nanoparticle hyperthermia using pluronic-coated Fe 3 O 4 nanoparticles: an in vitro study , 2012 .

[56]  Q. Pankhurst,et al.  Applications of magnetic nanoparticles in biomedicine , 2003 .

[57]  G. Frens.  Controlled Nucleation for the Regulation of the Particle Size in Monodisperse Gold Suspensions , 1973 .