Improved Detection of Circulating Epithelial Cells in Patients with Intraductal Papillary Mucinous Neoplasms

Early detection strategies for pancreatic ductal adenocarcinoma are needed. This article describes a high‐sensitivity platform for detection of epithelial cells shed from preneoplastic lesions at a high risk of becoming malignant and a combination of technologies that could be used for early detection of disease in high‐risk patients.

[1]  J. Zhao,et al.  Cell membrane-anchored MUC4 promotes tumorigenicity in epithelial carcinomas , 2016, Oncotarget.

[2]  I. Delladetsima,et al.  Mucins in neoplasms of pancreas, ampulla of Vater and biliary system , 2016, World journal of gastrointestinal oncology.

[3]  M. Sierzega,et al.  Semiquantitative immunohistochemistry for mucin (MUC1, MUC2, MUC3, MUC4, MUC5AC, and MUC6) profiling of pancreatic ductal cell adenocarcinoma improves diagnostic and prognostic performance , 2016, Histopathology.

[4]  I. Astsaturov,et al.  Prognostic Significance of MUC-1 in Circulating Tumor Cells in Patients With Metastatic Pancreatic Adenocarcinoma , 2016, Pancreas.

[5]  M. Otsuka,et al.  Quantitation of circulating satellite RNAs in pancreatic cancer patients. , 2016, JCI insight.

[6]  M. Falconi,et al.  Risk of pancreatic malignancy and mortality in branch-duct IPMNs undergoing surveillance: A systematic review and meta-analysis. , 2016, Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver.

[7]  Yibin Kang,et al.  Distinctive properties of metastasis-initiating cells , 2016, Genes & development.

[8]  Ben S. Wittner,et al.  Single-Cell RNA Sequencing Identifies Extracellular Matrix Gene Expression by Pancreatic Circulating Tumor Cells , 2014, Cell reports.

[9]  F. Colina-Ruizdelgado,et al.  Pathological features and diagnosis of intraductal papillary mucinous neoplasm of the pancreas. , 2014, World journal of gastrointestinal oncology.

[10]  Benjamin D. Smith,et al.  Projecting cancer incidence and deaths to 2030: the unexpected burden of thyroid, liver, and pancreas cancers in the United States. , 2014, Cancer research.

[11]  V. Velculescu,et al.  Blood-based analyses of cancer: circulating tumor cells and circulating tumor DNA. , 2014, Cancer discovery.

[12]  Timothy B Lannin,et al.  Detection of circulating pancreas epithelial cells in patients with pancreatic cystic lesions. , 2014, Gastroenterology.

[13]  Mehmet Toner,et al.  Inertial Focusing for Tumor Antigen–Dependent and –Independent Sorting of Rare Circulating Tumor Cells , 2013, Science Translational Medicine.

[14]  S. Batra,et al.  Mucin-based targeted pancreatic cancer therapy. , 2012, Current pharmaceutical design.

[15]  Sridhar Ramaswamy,et al.  RNA sequencing of pancreatic circulating tumour cells implicates WNT signaling in metastasis , 2012, Nature.

[16]  Jin‐Young Jang,et al.  International consensus guidelines 2012 for the management of IPMN and MCN of the pancreas. , 2012, Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.].

[17]  Maximilian Reichert,et al.  EMT and Dissemination Precede Pancreatic Tumor Formation , 2012, Cell.

[18]  A. Maitra,et al.  Recurrent GNAS Mutations Define an Unexpected Pathway for Pancreatic Cyst Development , 2011, Science Translational Medicine.

[19]  A. Iafrate,et al.  Aberrant Overexpression of Satellite Repeats in Pancreatic and Other Epithelial Cancers , 2011, Science.

[20]  Mehmet Toner,et al.  Isolation and Characterization of Circulating Tumor Cells from Patients with Localized and Metastatic Prostate Cancer , 2010, Science Translational Medicine.

[21]  S. Batra,et al.  Current status of mucins in the diagnosis and therapy of cancer , 2009, BioFactors.

[22]  R. Weinberg,et al.  Transitions between epithelial and mesenchymal states: acquisition of malignant and stem cell traits , 2009, Nature Reviews Cancer.

[23]  H. Friess,et al.  Mucin (MUC) gene expression in human pancreatic adenocarcinoma and chronic pancreatitis: a potential role of MUC4 as a tumor marker of diagnostic significance. , 2001, Clinical cancer research : an official journal of the American Association for Cancer Research.

[24]  Mithat Gönen,et al.  Multi-institutional Validation Study of the American Joint Commission on Cancer (8th Edition) Changes for T and N Staging in Patients With Pancreatic Adenocarcinoma , 2017, Annals of surgery.

[25]  M. Gonen,et al.  Pancreatic Cyst Fluid and Serum Mucin Levels Predict Dysplasia in Intraductal Papillary Mucinous Neoplasms of the Pancreas , 2010, Annals of Surgical Oncology.