A comprehensive model for x-ray projection imaging system efficiency and image quality characterization in the presence of scattered radiation.

This work proposes a method for assessing the detective quantum efficiency (DQE) of radiographic imaging systems that include both the x-ray detector and the antiscatter device. Cascaded linear analysis of the antiscatter device efficiency (DQEASD) with the x-ray detector DQE is used to develop a metric of system efficiency (DQEsys); the new metric is then related to the existing system efficiency parameters of effective DQE (eDQE) and generalized DQE (gDQE). The effect of scatter on signal transfer was modelled through its point spread function (PSF), leading to an x-ray beam transfer function (BTF) that multiplies with the classical presampling modulation transfer function (MTF) to give the system MTF. Expressions are then derived for the influence of scattered radiation on signal-difference to noise ratio (SDNR) and contrast-detail (c-d) detectability. The DQEsys metric was tested using two digital mammography systems, for eight x-ray beams (four with and four without scatter), matched in terms of effective energy. The model was validated through measurements of contrast, SDNR and MTF for poly(methyl)methacrylate thicknesses covering the range of scatter fractions expected in mammography. The metric also successfully predicted changes in c-d detectability for different scatter conditions. Scatter fractions for the four beams with scatter were established with the beam stop method using an extrapolation function derived from the scatter PSF, and validated through Monte Carlo (MC) simulations. Low-frequency drop of the MTF from scatter was compared to both theory and MC calculations. DQEsys successfully quantified the influence of the grid on SDNR and accurately gave the break-even object thickness at which system efficiency was improved by the grid. The DQEsys metric is proposed as an extension of current detector characterization methods to include a performance evaluation in the presence of scattered radiation, with an antiscatter device in place.

[1]  Daniel R. Bednarek,et al.  Generalized two-dimensional (2D) linear system analysis metrics (GMTF, GDQE) for digital radiography systems including the effect of focal spot, magnification, scatter, and detector characteristics , 2010, Medical Imaging.

[2]  Hilde Bosmans,et al.  Effective detective quantum efficiency for two mammography systems: measurement and comparison against established metrics. , 2013, Medical physics.

[3]  Nico Karssemeijer,et al.  The value of scatter removal by a grid in full field digital mammography. , 2003, Medical physics.

[4]  Remy Klausz,et al.  Grid removal and impact on population dose in full-field digital mammography. , 2007, Medical physics.

[5]  Horst Aichinger,et al.  Radiation Exposure and Image Quality in X-Ray Diagnostic Radiology , 2004 .

[6]  Ian A. Cunningham,et al.  Can a Fourier-based cascaded-systems analysis describe noise in complex shift-variant spatially sampled detectors? , 2004, SPIE Medical Imaging.

[7]  Ann-Katherine Carton,et al.  The effect of scatter and glare on image quality in contrast-enhanced breast imaging using an a-Si/CsI(TI) full-field flat panel detector. , 2009, Medical physics.

[8]  E. Samei,et al.  A method for measuring the presampled MTF of digital radiographic systems using an edge test device. , 1998, Medical physics.

[9]  G T Barnes,et al.  Mammography grid performance. , 1999, Radiology.

[10]  Dev P. Chakraborty The effect of the antiscatter grid on full-field digital mammography phantom images , 2009, Journal of Digital Imaging.

[11]  N W Marshall Detective quantum efficiency measured as a function of energy for two full-field digital mammography systems. , 2009, Physics in medicine and biology.

[12]  Ulrich Neitzel,et al.  Measurement of the modulation transfer function of digital X-ray detectors with an opaque edge-test device. , 2005, Radiation protection dosimetry.

[13]  J. Boone,et al.  Scatter/primary in mammography: comprehensive results. , 2000, Medical physics.

[14]  Hilde Bosmans,et al.  Comparison of software and human observers in reading images of the CDMAM test object to assess digital mammography systems , 2006, SPIE Medical Imaging.

[15]  Kenkichi Tanioka,et al.  X-ray imaging using avalanche multiplication in amorphous selenium: investigation of depth dependent avalanche noise. , 2007, Medical physics.

[16]  J. Sempau,et al.  A PENELOPE-based system for the automated Monte Carlo simulation of clinacs and voxelized geometries-application to far-from-axis fields. , 2011, Medical physics.

[17]  Ehsan Samei,et al.  Fundamental imaging characteristics of a slot-scan digital chest radiographic system. , 2004, Medical physics.

[18]  Ehsan Samei,et al.  Effective DQE (eDQE) and speed of digital radiographic systems: an experimental methodology. , 2009, Medical physics.

[19]  R. F. Wagner,et al.  Effect of reduced scatter on radiographic information content and patient exposure: a quantitative demonstration. , 1980, Medical physics.

[20]  Rodney Shaw,et al.  Signal-to-noise optimization of medical imaging systems , 1999 .

[21]  Björn Cederström,et al.  Scatter rejection in multislit digital mammography. , 2006, Medical physics.

[22]  Ehsan Samei,et al.  Comparative scatter and dose performance of slot-scan and full-field digital chest radiography systems. , 2005, Radiology.

[23]  J A Seibert,et al.  Characterization of the point spread function and modulation transfer function of scattered radiation using a digital imaging system. , 1986, Medical physics.

[24]  Ho Kyung Kim Generalized cascaded model to assess noise transfer in scintillator-based x-ray imaging detectors , 2006 .

[25]  F R Verdun,et al.  Image quality assessment in digital mammography: part II. NPWE as a validated alternative for contrast detail analysis , 2011, Physics in medicine and biology.

[26]  Hilde Bosmans,et al.  Tailoring automatic exposure control toward constant detectability in digital mammography. , 2015, Medical physics.

[27]  J Yorkston,et al.  Empirical and theoretical investigation of the noise performance of indirect detection, active matrix flat-panel imagers (AMFPIs) for diagnostic radiology. , 1997, Medical physics.

[28]  Ann-Katherine Carton,et al.  Validation of MTF measurement for digital mammography quality control. , 2005, Medical physics.

[29]  Idris Elbakri,et al.  Effect of scatter and an antiscatter grid on the performance of a slot-scanning digital mammography system. , 2006, Medical physics.

[30]  Ying Chen,et al.  Intercomparison of methods for image quality characterization. I. Modulation transfer function. , 2006, Medical physics.

[31]  D M Cunha,et al.  Evaluation of scatter-to-primary ratio, grid performance and normalized average glandular dose in mammography by Monte Carlo simulation including interference and energy broadening effects , 2010, Physics in medicine and biology.

[32]  Mauro Iori,et al.  A comparison of digital radiography systems in terms of effective detective quantum efficiency. , 2012, Medical physics.

[33]  Hilde Bosmans,et al.  Quantification of scattered radiation in projection mammography: four practical methods compared. , 2012, Medical physics.

[34]  Han Chen,et al.  On image quality metrics and the usefulness of grids in digital mammography , 2015, Journal of medical imaging.

[35]  M. Rabbani,et al.  Detective quantum efficiency of imaging systems with amplifying and scattering mechanisms. , 1987, Journal of the Optical Society of America. A, Optics and image science.

[36]  Ulrich Neitzel,et al.  Determination of the modulation transfer function using the edge method: influence of scattered radiation. , 2004, Medical physics.

[37]  K. Hoffmann,et al.  Generalizing the MTF and DQE to include x-ray scatter and focal spot unsharpness: application to a new microangiographic system. , 2005, Medical physics.

[38]  M A King,et al.  Experimental measurements of the scatter reduction obtained in mammography with a scanning multiple slit assembly. , 1981, Medical physics.

[39]  Kyle J Myers,et al.  Efficiency of the human observer compared to an ideal observer based on a generalized NEQ which incorporates scatter and geometric unsharpness: evaluation with a 2AFC experiment , 2005, SPIE Medical Imaging.

[40]  Ying Chen,et al.  Intercomparison of methods for image quality characterization. II. Noise power spectrum. , 2006, Medical physics.

[41]  R. Shaw,et al.  Evaluating the efficient of imaging processes , 1978 .

[42]  D. Jaffray,et al.  Optimization of x-ray imaging geometry (with specific application to flat-panel cone-beam computed tomography). , 2000, Medical physics.

[43]  N W Marshall,et al.  A comparison between objective and subjective image quality measurements for a full field digital mammography system , 2006, Physics in medicine and biology.

[44]  I A Cunningham,et al.  Normalization of the modulation transfer function: the open-field approach. , 2008, Medical physics.

[45]  U Neitzel,et al.  Grids or air gaps for scatter reduction in digital radiography: a model calculation. , 1992, Medical physics.

[46]  J. Boone,et al.  An accurate method for computer-generating tungsten anode x-ray spectra from 30 to 140 kV. , 1997, Medical physics.

[47]  S. Samant,et al.  Validity of the line-pair bar-pattern method in the measurement of the modulation transfer function (MTF) in megavoltage imaging. , 2007, Medical physics.

[48]  Robert Piessens,et al.  The Hankel Transform , 2000 .

[49]  R. F. Wagner,et al.  Toward consensus on quantitative assessment of medical imaging systems. , 1995, Medical physics.

[50]  K L Lam,et al.  Studies of performance of antiscatter grids in digital radiography: effect on signal-to-noise ratio. , 1990, Medical physics.

[51]  Hilde Bosmans,et al.  A comprehensive model for quantum noise characterization in digital mammography , 2016, Physics in medicine and biology.

[52]  J A Seibert,et al.  Characterization of the veiling glare PSF in x-ray image intensified fluoroscopy. , 1984, Medical physics.

[53]  J A Rowlands,et al.  Digital radiology using active matrix readout of amorphous selenium: theoretical analysis of detective quantum efficiency. , 1997, Medical physics.

[54]  F R Verdun,et al.  Comparison of the polynomial model against explicit measurements of noise components for different mammography systems. , 2014, Physics in medicine and biology.

[55]  Haimo Liu,et al.  Evaluation of clinical full field digital mammography with the task specific system-model-based Fourier Hotelling observer (SMFHO) SNR. , 2014, Medical physics.

[56]  J. Sempau,et al.  PENELOPE-2006: A Code System for Monte Carlo Simulation of Electron and Photon Transport , 2009 .

[57]  Stephen Rudin,et al.  Study of the generalized MTF and DQE for a new microangiographic system , 2004, SPIE Medical Imaging.