Bioprocess Design and Production Technology for the Future

[1]  Jochen Strube,et al.  Downstream of downstream processing: development of recycling strategies for biopharmaceutical processes , 2012 .

[2]  Holger Fröhlich,et al.  Integration of Reverse‐Osmosis Unit Operations in Biotechnology Process Design , 2012 .

[3]  Jochen Strube,et al.  Process Development and Design of Downstream Processes , 2011 .

[4]  Holger Fröhlich,et al.  Integration of Ultrafiltration Unit Operations in Biotechnology Process Design , 2011 .

[5]  Jochen Strube,et al.  Phenomena and Modeling of Hydrophobic Interaction Chromatography , 2011 .

[6]  Joachim Ulrich,et al.  Crystallization of Hen Egg White Lysozyme by Solvent Freeze‐Out: Effect of Cooling Rate on Protein Inclusion in the Ice Layer , 2010 .

[7]  J. Eggersglüß,et al.  Auslegung von Bioextraktionsverfahren durch Prozessmodellierung in Kombination mit Miniplant‐Versuchen am Beispiel der Antikörperaufreinigung , 2010 .

[8]  Gerhard Schembecker,et al.  Purification performance index and separation cost indicator for experimentally based systematic downstream process development , 2010 .

[9]  Gerhard Schembecker,et al.  Purification fingerprints for experimentally based systematic downstream process development , 2010 .

[10]  Jochen Strube,et al.  A New Approach for Process Development of Plant‐Based Extraction Processes , 2010 .

[11]  Nathalie Fraud,et al.  Development of a polishing step using a hydrophobic interaction membrane adsorber with a PER.C6®‐derived recombinant antibody , 2010, Biotechnology and bioengineering.

[12]  Marcel Ottens,et al.  Omics tools in accelerated purification process development: Multidimensional fractionation and characterization of crude protein mixtures , 2009 .

[13]  Alois Jungbauer Adsorption of proteins on hydrophobic interaction chromatography surfaces: Unfolding upon adsorption , 2009 .

[14]  Brian Kelley,et al.  Industrialization of mAb production technology: The bioprocessing industry at a crossroads , 2009, mAbs.

[15]  Janice M Reichert,et al.  Second international conference on accelerating biopharmaceutical development , 2009, Biotechnology progress.

[16]  Janice M Reichert,et al.  Second International Conference on Accelerating Biopharmaceutical Development: March 9-12, 2009, Coronado, CA USA , 2009, mAbs.

[17]  M. Aires-Barros,et al.  Application of aqueous two-phase systems to antibody purification: a multi-stage approach. , 2009, Journal of biotechnology.

[18]  Marcel Ottens,et al.  Protein self-interaction chromatography on a microchip. , 2009, Lab on a chip.

[19]  A. B. de Haan,et al.  Host-guest extraction of immunoglobulin G using calix[6]arenas , 2009 .

[20]  Xiaoming Yang,et al.  Implementation of advanced technologies in commercial monoclonal antibody production , 2008, Biotechnology journal.

[21]  Jörg Kressler,et al.  Cloning, expression, purification, and characterization of a designer protein with repetitive sequences. , 2008, Protein expression and purification.

[22]  Marcel Ottens,et al.  Design strategies for integrated protein purification processes: challenges, progress and outlook , 2008 .

[23]  Gerhard Schembecker,et al.  Synthese von Downstreamprozessen , 2008 .

[24]  Juan A. Asenjo,et al.  Challenges and trends in bioseparations , 2008 .

[25]  Arnold L. Demain,et al.  REVIEWS: The business of biotechnology , 2007 .

[26]  Marcus Degerman,et al.  Modeling and optimization of preparative reversed-phase liquid chromatography for insulin purification. , 2007, Journal of chromatography. A.

[27]  Andrew L. Zydney,et al.  Bioprocess membrane technology , 2007 .

[28]  Duncan Low,et al.  Future of antibody purification. , 2007, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

[29]  Brian Kelley,et al.  Very Large Scale Monoclonal Antibody Purification: The Case for Conventional Unit Operations , 2007, Biotechnology progress.

[30]  Ludwig Deibele,et al.  Miniplant-Technik: in der Prozessindustrie , 2006 .

[31]  Sven-Olof Enfors,et al.  Recovery of recombinant beta-glucosidase by expanded bed adsorption from Pichia pastoris high-cell-density culture broth. , 2006, Journal of biotechnology.

[32]  Wolfgang Peukert,et al.  Die Bedeutung des zweiten osmotischen Virialkoeffizienten für die Proteinkristallisation , 2006 .

[33]  Lu Wang,et al.  Purification of humanized monoclonal antibody by hydrophobic interaction membrane chromatography. , 2006, Journal of chromatography. A.

[34]  Jee-Young Imm,et al.  One-step separation of lysozyme by reverse micelles formed by the cationic surfactant, cetyldimethylammonium bromide , 2005 .

[35]  Jochen Strube,et al.  Generic method for systematic phase selection and method development of biochromatographic processes. Part I. Selection of a suitable cation-exchanger for the purification of a pharmaceutical protein. , 2005, Journal of chromatography. A.

[36]  Jochen Strube,et al.  Challenges in biotechnology production—generic processes and process optimization for monoclonal antibodies , 2005 .

[37]  Klaus Sattler,et al.  Thermische Trennverfahren: Grundlagen, Auslegung, Apparate , 2005 .

[38]  Jörg Peters,et al.  Implementation of a crystallization step into the purification process of a recombinant protein. , 2005, Protein expression and purification.

[39]  Jörg Thömmes,et al.  Biochemical engineering aspects of expanded bed adsorption. , 2005, Advances in biochemical engineering/biotechnology.

[40]  Barbara Andrews,et al.  Optimal Process Synthesis for the Production of Multiple Recombinant Proteins , 2004, Biotechnology progress.

[41]  Kyoichi Saito,et al.  Protein binding to polymer brush, based on ion-exchange, hydrophobic, and affinity interactions. , 2003, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

[42]  A. Darling,et al.  Validation of biopharmaceutical purification processes for virus clearance evaluation , 2002, Molecular biotechnology.

[43]  Jose M. Pinto,et al.  Mixed integer optimization models for the Synthesis of Protein Purification Processes with product loss , 2002 .

[44]  Arno P. Biwer,et al.  Prozesssimulation zur frühen ökologischen Bewertung biotechnologischer Prozesse: Beispiel Zitronensäure , 2001 .

[45]  Peter L. Douglas,et al.  Computer simulation for large scale bioprocess design , 2001 .

[46]  J A Asenjo,et al.  Process performance models in the optimization of multiproduct protein production plants. , 2001, Biotechnology and bioengineering.

[47]  Dong-Qiang Lin,et al.  Minimising biomass/adsorbent interactions in expanded bed adsorption processes: a methodological design approach , 2001, Bioseparation (Dordrecht).

[48]  Aldo R. Vecchietti,et al.  Strategies for the simultaneous optimization of the structure and the process variables of a protein production plant , 2000 .

[49]  I D Bogle,et al.  Synthesis of bioprocesses using physical properties data. , 2000, Biotechnology and bioengineering.

[50]  F B Anspach,et al.  Endotoxin removal from protein solutions. , 2000, Journal of biotechnology.

[51]  W. Deckwer,et al.  Expanded-bed chromatography in primary protein purification. , 1999, Journal of chromatography. A.

[52]  E. Boschetti,et al.  Characterization of very dense mineral oxide–gel composites for fluidized-bed adsorption of biomolecules , 1999, Bioseparation.

[53]  William R. Strohl,et al.  Biotechnology of Antibiotics, Second Edition, , 1997 .

[54]  R Hjorth,et al.  Expanded-bed adsorption in industrial bioprocessing: recent developments. , 1997, Trends in biotechnology.

[55]  S. Johansson,et al.  Expanded bed adsorption at production scale: Scale-up verification, process example and sanitization of column and adsorbent , 1997 .

[56]  J Thömmes,et al.  Fluidized bed adsorption as a primary recovery step in protein purification. , 1997, Advances in biochemical engineering/biotechnology.

[57]  M. Kula,et al.  Hydrodynamics and performance in fluidized bed adsorption. , 1995, Biotechnology and bioengineering.

[58]  Rafiqul Gani,et al.  SEPARATION PROCESS DESIGN AND SYNTHESIS BASED ON THERMODYNAMIC INSIGHTS , 1995 .

[59]  Karl Schügerl,et al.  Solvent Extraction in Biotechnology , 1994 .

[60]  M. Ladisch,et al.  Recombinant Human Insulin , 1992, Biotechnology progress.

[61]  H. Chase,et al.  Affinity purification of proteins using expanded beds. , 1992, Journal of chromatography.

[62]  M. Burns,et al.  Continuous protein separations in a magnetically stabilized fluidized bed using nonmagnetic supports , 1991, Biotechnology and bioengineering.

[63]  R. Owens,et al.  Production scale purification of biosynthetic human insulin by reversed-phase high-performance liquid chromatography. , 1989, Journal of chromatography.

[64]  D. Graves,et al.  Continuous Affinity Chromatography Using a Magnetically Stabilized Fluidized Bed , 1985, Biotechnology progress.

[65]  J. Ferry,et al.  Ultrafilter Membranes and Ultrafiltration. , 1936 .