G2 phase chromatin lacks determinants of replication timing

Chromatin spatial organization helps establish the replication timing decision point at early G1. However, at G2, although retained, chromatin organization is no longer necessary or sufficient to maintain the replication timing program.

[1]  Dirk Schübeler,et al.  Global Reorganization of Replication Domains During Embryonic Stem Cell Differentiation , 2008, PLoS biology.

[2]  A. Imhof,et al.  Establishment of Histone Modifications after Chromatin Assembly , 2009, Nucleic acids research.

[3]  D. Gilbert,et al.  Regulation of mammalian replication origin usage in Xenopus egg extract. , 1998, Journal of cell science.

[4]  H. Leonhardt,et al.  Dynamics of DNA Replication Factories in Living Cells , 2000, The Journal of cell biology.

[5]  J. Bridger,et al.  Alterations to Nuclear Architecture and Genome Behavior in Senescent Cells , 2007, Annals of the New York Academy of Sciences.

[6]  Jean Thierry-Mieg,et al.  Predictable dynamic program of timing of DNA replication in human cells. , 2009, Genome research.

[7]  D. Gilbert,et al.  The spatial position and replication timing of chromosomal domains are both established in early G1 phase. , 1999, Molecular cell.

[8]  G. H. Leno,et al.  Initiation of DNA replication in nuclei from quiescent cells requires permeabilization of the nuclear membrane , 1994, The Journal of cell biology.

[9]  David M. Gilbert,et al.  Domain-wide regulation of DNA replication timing during mammalian development , 2009, Chromosome Research.

[10]  D L Spector,et al.  Dynamic organization of DNA replication in mammalian cell nuclei: spatially and temporally defined replication of chromosome-specific alpha-satellite DNA sequences , 1992, The Journal of cell biology.

[11]  M. Groudine,et al.  The Control of Mammalian DNA Replication A Brief History of Space and Timing , 2001, Cell.

[12]  R. Laskey,et al.  The nuclear membrane prevents replication of human G2 nuclei but not G1 nuclei in Xenopus egg extract , 1992, Cell.

[13]  D. Gilbert,et al.  Origin-specific initiation of mammalian nuclear DNA replication in a Xenopus cell-free system. , 1997, Methods.

[14]  D. Gilbert,et al.  Proliferation-dependent and cell cycle–regulated transcription of mouse pericentric heterochromatin , 2007, The Journal of cell biology.

[15]  D. Gilbert,et al.  Replication timing and transcriptional control: beyond cause and effect. , 2009, Current opinion in cell biology.

[16]  H. Leonhardt,et al.  Stable chromosomal units determine the spatial and temporal organization of DNA replication , 2004, Journal of Cell Science.

[17]  Karel Koberna,et al.  The chromatin remodeling complex NoRC controls replication timing of rRNA genes , 2005, The EMBO journal.

[18]  D. Gilbert.  Nuclear Position Leaves Its Mark on Replication Timing , 2001, The Journal of cell biology.

[19]  Edward J Oakeley,et al.  Chromatin state marks cell-type- and gender-specific replication of the Drosophila genome. , 2009, Genes & development.

[20]  Daniel Axelrod,et al.  Chromatin Dynamics in Interphase Nuclei and Its Implications for Nuclear Structure , 1997, The Journal of cell biology.

[21]  D. Gilbert,et al.  Replication timing and transcriptional control: beyond cause and effect--part II. , 2002, Current Opinion in Genetics and Development.

[22]  S. Dalton,et al.  Evolutionarily conserved replication timing profiles predict long-range chromatin interactions and distinguish closely related cell types. , 2010, Genome research.

[23]  A. Harvey,et al.  Rapid chromosome territory relocation by nuclear motor activity in response to serum removal in primary human fibroblasts , 2010, Genome Biology.

[24]  J. Julian Blow,et al.  Preventing re-replication of chromosomal DNA , 2005, Nature Reviews Molecular Cell Biology.

[25]  D. Gilbert,et al.  Differential subnuclear localization and replication timing of histone H3 lysine 9 methylation states. , 2005, Molecular biology of the cell.

[26]  D. Gilbert,et al.  Replication timing and transcriptional control: beyond cause and effect--part II. , 2002, Current opinion in genetics & development.

[27]  S. Gasser,et al.  Chromosome Dynamics in the Yeast Interphase Nucleus , 2001, Science.

[28]  S. Gasser,et al.  The Positioning and Dynamics of Origins of Replication in the Budding Yeast Nucleus , 2001, The Journal of cell biology.

[29]  T. Hunt,et al.  An essential role for Cdk1 in S phase control is revealed via chemical genetics in vertebrate cells , 2007, The Journal of cell biology.

[30]  G. Almouzni,et al.  Mouse centric and pericentric satellite repeats form distinct functional heterochromatin , 2004, The Journal of cell biology.

[31]  A. Donaldson,et al.  Release of yeast telomeres from the nuclear periphery is triggered by replication and maintained by suppression of Ku-mediated anchoring. , 2008, Genes & development.

[32]  J. Pines,et al.  Stability, chromatin association and functional activity of mammalian pre‐replication complex proteins during the cell cycle , 2001, The EMBO journal.

[33]  D. Spector,et al.  A genetic locus targeted to the nuclear periphery in living cells maintains its transcriptional competence , 2008, The Journal of cell biology.

[34]  L. Vassilev,et al.  Cell Cycle Synchronization at the G2/M Phase Border by Reversible Inhibition of CDK1 , 2006, Cell cycle.

[35]  Itamar Simon,et al.  Genome-wide analysis of the replication program in mammals , 2009, Chromosome Research.

[36]  R. Laskey,et al.  Protein kinase inhibition in G2 causes mammalian Mcm proteins to reassociate with chromatin and restores ability to replicate. , 1998, Experimental cell research.

[37]  Shannon Amoils,et al.  The impact of chromatin modifiers on the timing of locus replication in mouse embryonic stem cells , 2007, Genome Biology.

[38]  H. Cedar,et al.  DNA replication timing of the human beta-globin domain is controlled by histone modification at the origin. , 2008, Genes & development.

[39]  Hiroshi Kimura,et al.  Kinetics of Core Histones in Living Human Cells , 2001, The Journal of cell biology.

[40]  J. Walter,et al.  Strength in numbers: preventing rereplication via multiple mechanisms in eukaryotic cells. , 2007, Genes & development.

[41]  J. Blow,et al.  A role for the nuclear envelope in controlling DNA replication within the cell cycle , 1988, Nature.

[42]  W. V. van Cappellen,et al.  Dynamics of relative chromosome position during the cell cycle. , 2004, Molecular biology of the cell.

[43]  J. Diffley,et al.  Regulation of Early Events in Chromosome Replication , 2004, Current Biology.

[44]  Ernst H. K. Stelzer,et al.  Structure and dynamics of human interphase chromosome territories in vivo , 1998, Human Genetics.

[45]  I. Amit,et al.  Comprehensive mapping of long range interactions reveals folding principles of the human genome , 2011 .

[46]  Bernadett Papp,et al.  Genome-wide dynamics of replication timing revealed by in vitro models of mouse embryogenesis. , 2010, Genome research.

[47]  David M. MacAlpine,et al.  A genomic view of eukaryotic DNA replication , 2005, Chromosome Research.

[48]  D. Prescott,et al.  Late S phase cells (Chinese hamster ovary) induce early S phase DNA labeling patterns in G1 phase nuclei. , 1978, Proceedings of the National Academy of Sciences of the United States of America.

[49]  Zohar Yakhini,et al.  Global organization of replication time zones of the mouse genome. , 2008, Genome research.

[50]  Wendy A Bickmore,et al.  Chromatin Motion Is Constrained by Association with Nuclear Compartments in Human Cells , 2002, Current Biology.

[51]  M. Nakao,et al.  Polycomb Group Protein-associated Chromatin Is Reproduced in Post-mitotic G1 Phase and Is Required for S Phase Progression* , 2008, Journal of Biological Chemistry.

[52]  Thomas Cremer,et al.  Chromosome order in HeLa cells changes during mitosis and early G1, but is stably maintained during subsequent interphase stages , 2003, The Journal of cell biology.

[53]  D. Gilbert,et al.  Uncoupling global and fine-tuning replication timing determinants for mouse pericentric heterochromatin , 2006, The Journal of cell biology.

[54]  D. Gilbert,et al.  Mcm2, but Not Rpa, Is a Component of the Mammalian Early G1-Phase Prereplication Complex , 1999, The Journal of cell biology.

[55]  W. L. Fangman,et al.  Cell cycle-dependent establishment of a late replication program. , 1997, Science.

[56]  J. Blow,et al.  Replication factory activation can be decoupled from the replication timing program by modulating Cdk levels , 2010, The Journal of cell biology.

[57]  M. C. Butler,et al.  The replication timing program of the Chinese hamster β-globin locus is established coincident with its repositioning near peripheral heterochromatin in early G1 phase , 2001, The Journal of cell biology.

[58]  Ichiro Hiratani,et al.  ReplicationDomain: a visualization tool and comparative database for genome-wide replication timing data , 2008, BMC Bioinformatics.

[59]  S. Gasser,et al.  Early initiation of a replication origin tethered at the nuclear periphery , 2010, Journal of Cell Science.

[60]  H. Niida,et al.  Cyclin A–Cdk1 regulates the origin firing program in mammalian cells , 2009, Proceedings of the National Academy of Sciences.

[61]  C Cremer,et al.  Organization of early and late replicating DNA in human chromosome territories. , 1999, Experimental cell research.

[62]  Timothy J. Mitchison,et al.  A chemical method for fast and sensitive detection of DNA synthesis in vivo , 2008, Proceedings of the National Academy of Sciences.

[63]  Hongmao Sun,et al.  Selective small-molecule inhibitor reveals critical mitotic functions of human CDK1. , 2006, Proceedings of the National Academy of Sciences of the United States of America.

[64]  Yoichi Shinkai,et al.  G9a selectively represses a class of late-replicating genes at the nuclear periphery , 2009, Proceedings of the National Academy of Sciences.

[65]  W. Bickmore,et al.  Re-modelling of nuclear architecture in quiescent and senescent human fibroblasts , 2000, Current Biology.

[66]  Gail Sudlow,et al.  Interphase Cell Cycle Dynamics of a Late-Replicating, Heterochromatic Homogeneously Staining Region: Precise Choreography of Condensation/Decondensation and Nuclear Positioning , 1998, The Journal of cell biology.