Hydrodynamic effects on animal cells in microcarrier bioreactors.

Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Chemical Engineering, 1988.

[1]  Y. Sano,et al.  MASS TRANSFER COEFFICIENTS FOR SUSPENDED PARTICLES IN AGITATED VESSELS AND BUBBLE COLUMNS , 1974 .

[2]  M. Stoker,et al.  Shaking 3T3 cells: further studies on diffusion boundary effects. , 1974, Cell.

[3]  L R Sauvage,et al.  An apparatus to study the response of cultured endothelium to shear stress. , 1986, Journal of biomechanical engineering.

[4]  R. Kuboi,et al.  Fluid and particle motion in turbulent dispersion—II , 1974 .

[5]  M S Croughan,et al.  Reversible removal and hydrodynamic phenomena in CHO microcarrier cultures. , 1990, Biotechnology and bioengineering.

[6]  A J Sinskey,et al.  Effect of shear on the death of two strains of mammalian tissue cells , 1971, Biotechnology and bioengineering.

[7]  H. Rasmussen,et al.  The effect of oxygen tension on the growth and metabolism of WI‐38 cells , 1976, Journal of cellular physiology.

[8]  Lawrence L. Tavlarides,et al.  Turbulent flow in stirred tanks. Part I: Turbulent flow in the turbine impeller region , 1985 .

[9]  J Meier,et al.  A mechanistic analysis of the inoculum requirement for the cultivation of mammalian cells on microcarriers , 1985, Biotechnology and bioengineering.

[10]  R. F. Parker,et al.  Effect of Pluronic F68 on Growth of Fibroblasts in Suspension on Rotary Shaker , 1960, Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine.

[11]  D. I. Wang,et al.  Effects of microcarrier concentration in animal cell culture , 1988, Biotechnology and bioengineering.

[12]  R M Hochmuth,et al.  Uniaxial loading of the red-cell membrane. , 1972, Journal of biomechanics.

[13]  W A Hyman,et al.  Shear flow over a protrusion from a plane wall: addendum. , 1972, Journal of biomechanics.

[14]  P. C. Hiemenz,et al.  Principles of colloid and surface chemistry , 1977 .

[15]  S. Nagata Mixing: Principles and Applications , 1975 .

[16]  R. H. Myers,et al.  Probability and Statistics for Engineers and Scientists , 1978 .

[17]  E. Papoutsakis,et al.  Damage mechanisms of suspended animal cells in agitated bioreactors with and without bubble entrainment , 1990, Biotechnology and bioengineering.

[18]  P. Greenfield,et al.  A technique for determining the shear sensitivity of mammalian cells in suspension culture , 1987 .

[19]  N. G. Maroudas Appendix: Short-range diffusion gradients , 1974 .

[20]  M. G. P. STOKER,et al.  Role of Diffusion Boundary Layer in Contact Inhibition of Growth , 1973, Nature.

[21]  M. Bixon,et al.  Dynamics of polymer molecules in dilute solutions , 1973 .

[22]  J. Pontén,et al.  The division cycle and RNA-synthesis in diploid human cells at different passage levels in vitro. , 1966, Experimental cell research.

[23]  C. Goochee,et al.  Response of a Mouse Hybridoma Cell Line to Heat Shock, Agitation, and Sparging , 1989 .

[24]  C F Dewey,et al.  The dynamic response of vascular endothelial cells to fluid shear stress. , 1981, Journal of biomechanical engineering.

[25]  J. Mcmahon,et al.  Purification and properties of a rat liver protein that specifically inhibits the proliferation of nonmalignant epithelial cells from rat liver. , 1982, Proceedings of the National Academy of Sciences of the United States of America.

[26]  P. Langen,et al.  Specific neutralizing antiserum against a polypeptide growth inhibitor for mammary cells purified from bovine mammary gland. , 1985, Biochimica et biophysica acta.

[27]  Daniel I. C. Wang,et al.  Effects of paddle impeller geometry on power input and mass transfer in small‐scale animal cell culture vessels , 1989, Biotechnology and bioengineering.

[28]  J. Vlak,et al.  Bioreactor design for growth of shear-sensitive mammalian and insect cells. , 1988, Advances in biotechnological processes.

[29]  R M Nerem,et al.  An application of the micropipette technique to the measurement of the mechanical properties of cultured bovine aortic endothelial cells. , 1987, Journal of biomechanical engineering.

[30]  L. Tolmach,et al.  Growth and nucleic acid synthesis in synchronously dividing populations of HeLa cells. , 1963, Experimental cell research.

[31]  M. Sharma,et al.  Alterations in bovine endothelial histidine decarboxylase activity following exposure to shearing stresses. , 1974, Experimental and molecular pathology.

[32]  A. Mizrahi Oxygen in human lymphoblastoid cell line cultures and effect of polymers in agitated and aerated cultures. , 1983, Developments in biological standardization.

[33]  David M. Prescott,et al.  Reproduction of eukaryotic cells , 1976 .

[34]  J. Hoyt Drag reduction in polysaccharide solutions , 1985 .

[35]  M. Kamiwano,et al.  Turbulent Flow in a Stirred Vessel , 1967 .

[36]  W. Runyan,et al.  Growth of L Cell Suspensions on a Warburg Apparatus.∗ , 1963, Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine.

[37]  N. Wright,et al.  An Introduction to Cell Population Kinetics , 1978 .

[38]  J. M. Deforrest,et al.  Relationship between low intensity shear stress, aortic histamine formation, and aortic albumin uptake. , 1980, Experimental and molecular pathology.

[39]  Alvin W. Nienow,et al.  The dependency on scale of power numbers of Rushton disc turbines , 1987 .

[40]  M. J. Johnson,et al.  Trace-metal requirements of NCTC clone 929 strain L cells. , 1967, Journal of the National Cancer Institute.

[41]  A J Sinskey,et al.  PRODUCTION OF CELL‐DERIVED PRODUCTS: VIRUS AND INTERFERON * , 1981, Annals of the New York Academy of Sciences.

[42]  M. Tyo,et al.  ENGINEERING CHARACTERIZATION OF ANIMAL CELL AND VIRUS PRODUCTION USING CONTROLLED CHARGE MICROCARRIERS , 1981 .

[43]  T. W. James,et al.  Assay for nanogram quantities of DNA in cellular homogenates. , 1979, Analytical biochemistry.

[44]  S. J. Pirt,et al.  Principles of microbe and cell cultivation , 1975 .

[45]  R. Spier,et al.  An examination of the data and concepts germane to the oxygenation of cultured animal cells. , 1983, Developments in biological standardization.

[46]  R. Reid,et al.  The Properties of Gases and Liquids , 1977 .

[47]  G. Dunn,et al.  New evidence that growth in 3T3 cell cultures is a diffusion-limited process , 1984, Nature.

[48]  L Y Cheng Deformation analyses in cell and developmental biology. Part I--Formal methodology. , 1987, Journal of biomechanical engineering.

[49]  B. Holmström Continuous flow cultures of a HeLa cell line as a basis for a steady supply of Rubella virus , 1968 .

[50]  J. Birch,et al.  Large-scale cell culture in biotechnology. , 1986, Science.

[51]  C. Goochee,et al.  Scaleup of Insect Cell Cultures: Protective Effects of Pluronic F-68 , 1988, Bio/Technology.

[52]  W. R. Schowalter,et al.  Simple shear flow round a rigid sphere: inertial effects and suspension rheology , 1970, Journal of Fluid Mechanics.

[53]  R. Spier,et al.  The adhesion of animal cells to surfaces: The measurement of critical surface shear stress permitting attachment or causing detachment , 1985 .

[54]  R M Nerem,et al.  Micropipette Aspiration of Cultured Bovine Aortic Endothelial Cells Exposed to Shear Stress , 1987, Arteriosclerosis.

[55]  S. Shiigi,et al.  Sera and the in vitro induction of immune responses. I. Bacterial contamination and the generation of good fetal bovine sera. , 1975, Journal of immunology.

[56]  L. McIntire,et al.  Shear Stress Effects on Human T Cell Function , 1988 .

[57]  R. Mashelkar,et al.  Influence of drag reducing additives on mixing and dispersing in agitated vessels , 1977 .

[58]  亮一 久保井 Fluid and particle motion in turbulent dispersion , 1974 .

[59]  D. J. Merchant,et al.  The mechanism of cell binding and cell-sheet formation in L strain fibroblasts. , 1960, Experimental cell research.

[60]  D. Kleinbaum,et al.  Applied Regression Analysis and Other Multivariate Methods , 1978 .

[61]  W. Thilly,et al.  Selection of mitotic Chinese hamster ovary cells from microcarriers. , 1980, Analytical biochemistry.

[62]  Raghunath V. Chaudhari,et al.  Three phase slurry reactors , 1980 .

[63]  E. Papoutsakis,et al.  Physical mechanisms of cell damage in microcarrier cell culture bioreactors , 1988, Biotechnology and bioengineering.

[64]  D. Kirwan,et al.  Effects of stirring and sparging on cultured hybridoma cells , 1990, Biotechnology and bioengineering.

[65]  C. Goochee,et al.  Structural Features of Nonionic Polyglycol Polymer Molecules Responsible for the Protective Effect in Sparged Animal Cell Bioreactors , 1990, Biotechnology progress.

[66]  J. Bryant Methylcellulose effect on cell proliferation and glucose utilization in chemically defined medium in large stationary cultures , 1969, Biotechnology and bioengineering.

[67]  T. M. Hollis,et al.  Effects of shearing stress on aortic histamine synthesis. , 1974, Experimental and molecular pathology.

[68]  M S Croughan,et al.  Growth and death in overagitated microcarrier cell cultures , 1989, Biotechnology and bioengineering.

[69]  D. L. Fry Acute Vascular Endothelial Changes Associated with Increased Blood Velocity Gradients , 1968, Circulation research.

[70]  J. Tramper,et al.  Shear sensitivity of insect cells in suspension , 1986 .

[71]  J. Bryant MAMMALIAN CELLS IN CHEMICALLY DEFINED MEDIA IN SUSPENSION CULTURES * , 1966, Annals of the New York Academy of Sciences.

[72]  Cell Growth. , 1962, Science.

[73]  Larry V. McIntire,et al.  Shear sensitivity of cultured hybridoma cells (CRL-8018) depends on mode of growth, culture age and metabolite concentration , 1988 .

[74]  A. V. van Wezel Growth of Cell-strains and Primary Cells on Micro-carriers in Homogeneous Culture , 1967, Nature.

[75]  J. Clark,et al.  OPTIMIZING CULTURE CONDITIONS FOR THE PRODUCTION OF ANIMAL CELLS IN MICROCARRIER CULTURE , 1981, Annals of the New York Academy of Sciences.

[76]  Robert S. Cherry,et al.  Hydrodynamic effects on cells in agitated tissue culture reactors , 1986 .

[77]  Alvin W. Nienow,et al.  The effects of agitation intensity with and without continuous sparging on the growth and antibody production of hybridoma cells , 1989 .

[78]  Robert K. Finn,et al.  A model system for evaluating shear in the design of stirred fermentors , 1966 .

[79]  Daniel I. C. Wang,et al.  Viscous reduction of turbulent damage in animal cell culture , 1989, Biotechnology and bioengineering.

[80]  Th.N. Zwietering Suspending of solid particles in liquid by agitators , 1958 .

[81]  M S Croughan,et al.  Hydrodynamic effects on animal cells grown in microcarrier cultures , 1987, Biotechnology and bioengineering.

[82]  J. Hamlin,et al.  Animal cell cycle. , 1978, Annual review of biochemistry.

[83]  L V McIntire,et al.  Flow effects on prostacyclin production by cultured human endothelial cells. , 1985, Science.

[84]  R. Bates,et al.  Examination of Some Geometric Parameters of Impeller Power , 1963 .

[85]  J. Birch,et al.  Growth and oxygen requirements of antibody producing mouse hybridoma cells in suspension culture. , 1983, Developments in biological standardization.

[86]  S. Pirt,et al.  The choline and serum protein requirements of mouse fibroblast cells (strain LS) in culture. , 1969, Journal of cell science.

[87]  Daniel I. C. Wang,et al.  Human interferon production with diploid fibroblast cells grown on microcarriers , 1979, Biotechnology and bioengineering.

[88]  H. A. Johnson Some problems associated with the histological study of cell proliferation kinetics. , 1961 .

[89]  R M Nerem,et al.  The elongation and orientation of cultured endothelial cells in response to shear stress. , 1985, Journal of biomechanical engineering.

[90]  R M Nerem,et al.  Influence of a laminar steady-state fluid-imposed wall shear stress on the binding, internalization, and degradation of low-density lipoproteins by cultured arterial endothelium. , 1987, Circulation.

[91]  W. Hyman Shear flow over a protrusion from a plane wall. , 1972, Journal of biomechanics.

[92]  N. Stathopoulos,et al.  Shear stress effects on human embryonic kidney cells in Vitro , 1985, Biotechnology and bioengineering.

[93]  J. M. Vlak,et al.  Bubble-column design for growth of fragile insect cells , 1988 .

[94]  T. Matsuo,et al.  Forces Acting on Floc and Strength of Floc , 1981 .